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浏览/检索结果: 共19条，第1-10条 帮助 限定条件 发表日期：2014    专题：北京大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of binding proteins for a protein target using protein-protein docking-based virtual screening 期刊论文 proteins structure function and bioinformatics, 2014 Zhang, Changsheng; Tang, Bo; Wang, Qian; Lai, Luhua 收藏  |  浏览/下载：2/0  |  提交时间：2015/11/13 protein-protein docking  virtual screening  protein design  protein-protein interaction prediction  binding energy landscape  TNF alpha  COMPUTATIONAL DESIGN  CRYSTAL-STRUCTURE  DRUG DESIGN  TNF-ALPHA  THERAPEUTICS  PERSPECTIVE  PREDICTION  SCAFFOLDS  EVOLUTION  BIOLOGY   Protein-Protein Interface Analysis and Hot Spots Identification for Chemical Ligand Design 期刊论文 current pharmaceutical design, 2014 Chen, Jing; Ma, Xiaomin; Yuan, Yaxia; Pei, Jianfeng; Lai, Luhua 收藏  |  浏览/下载：7/0  |  提交时间：2015/11/13 Protein-protein interface analysis  small molecular binder  binding site detection  ligandability  hot spots  Pocket V.3  SMALL-MOLECULE INHIBITORS  DRUG DISCOVERY  BINDING-SITES  CONFORMATIONAL DYNAMICS  STRUCTURAL BIOLOGY  TRANSIENT POCKETS  PREDICTION  ALLOSTERY  DRUGGABILITY  MODULATION   Mutational analysis of dimeric linkers in peri- and cytoplasmic domains of histidine kinase DctB reveals their functional roles in signal transduction 期刊论文 2014 Liu, Jiwei; Yang, Jianguo; Wen, Jin; Yang, Yun; Wei, Xiaolu; Zhang, Xiaodong; Wang, Yi-Ping 收藏  |  浏览/下载：14/0  |  提交时间：2015/11/13 DctB  two-component system  transmembrane signal transduction  MULTIPLE SEQUENCE ALIGNMENT  COILED COILS  GENETIC-ANALYSIS  SENSOR KINASES  PROTEINS  MECHANISM  HELIX  TRANSPORT  CHEMORECEPTORS  TRANSMISSION   Bioinformatic analysis of the nucleotide binding site-encoding disease-resistance genes in foxtail millet (Setaria italica (L.) Beauv.) 期刊论文 genetics and molecular research, 2014 Zhu, Y. B.; Xie, X. Q.; Li, Z. Y.; Bai, H.; Dong, L.; Dong, Z. P.; Dong, J. G. 收藏  |  浏览/下载：2/0  |  提交时间：2015/11/13 Foxtail millet  Gene clusters  Phylogenetic tree  Database  Nucleotide-binding site  GENOME-WIDE IDENTIFICATION  NBS  ARABIDOPSIS  EVOLUTION  HOMOLOGS  SEQUENCE   Molecular docking and molecular dynamics studies on the structure-activity relationship of fluoroquinolone for the HERG channel 期刊论文 分子生物系统, 2014 Luo, Fang; Gu, Jiangyong; Chen, Lirong; Xu, Xiaojie 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/10 POLYMORPHIC VENTRICULAR-TACHYCARDIA  INTERVAL PROLONGATION  POTASSIUM CHANNEL  FREE-ENERGY  K+ CHANNEL  CARDIAC-ARRHYTHMIA  LIGAND-BINDING  QT INTERVAL  FORCE-FIELD  DRUG   Electrospray ionization mass spectrometry probing of binding affinity of berbamine, a flexible cyclic alkaloid from traditional Chinese medicine, with G-quadruplex DNA 期刊论文 质谱学快讯, 2014 Tan, Wei; Zhou, Jiang; Yuan, Gu 收藏  |  浏览/下载：4/0  |  提交时间：2015/11/10 ONCOGENIC PROMOTER  CIRCULAR-DICHROISM  HUMAN GENOME  RECOGNITION  SEQUENCE  LIGANDS  REGION  STABILIZATION  SCAFFOLD  GENE   Methylene Blue as a G-Quadruplex Binding Probe for Label-Free Homogeneous Electrochemical Biosensing 期刊论文 analytical chemistry, 2014 Zhang, Fang-Ting; Nie, Ji; Zhang, De-Wen; Chen, Ji-Tao; Zhou, Ying-Lin; Zhang, Xin-Xiang 收藏  |  浏览/下载：12/0  |  提交时间：2015/11/11 PEROXIDASE-ACTIVITY  FLUORESCENT-PROBE  VISUAL DETECTION  DNA  COMPLEX  HAIRPIN  SENSOR  AMPLIFICATION  ELECTRODES  STABILITY   Systems Biology Brings New Dimensions for Structure-Based Drug Design 期刊论文 journal of the american chemical society, 2014 Pei, Jianfeng; Yin, Ning; Ma, Xiaomin; Lai, Luhua 收藏  |  浏览/下载：2/0  |  提交时间：2015/11/10 PROTEIN-PROTEIN INTERACTIONS  SMALL-MOLECULE INHIBITORS  DE-NOVO DESIGN  TRADITIONAL CHINESE MEDICINE  ACID METABOLIC NETWORK  OF-THE-ART  BINDING-SITES  COMPUTATIONAL METHODS  COMBINATION THERAPY  ANTICANCER STRATEGY   Discovery of highly potent TNF alpha inhibitors using virtual screen 期刊论文 欧洲医药化学杂志, 2014 Shen, Qi; Chen, Jing; Wang, Qian; Deng, Xiaobing; Liu, Ying; Lai, Luhua 收藏  |  浏览/下载：6/0  |  提交时间：2015/11/11 TNF alpha  Virtual screen  Small molecule inhibitors  TUMOR-NECROSIS-FACTOR  SMALL-MOLECULE INHIBITORS  PROMISCUOUS INHIBITORS  FACTOR ANTAGONISTS  SURAMIN  OLIGOMERIZATION  SUPERFAMILY  GENERATION  DOCKING  BINDING   Cellular surface characteristics of Saccharomyces cerevisiae before and after Ag(I) biosorption 期刊论文 生物资源技术, 2014 Chen, Can; Wen, Donghui; Wang, Jianlong 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/11 Saccharomyces cerevisiae  Silver  Biosorption  Cellular surface  ATOMIC-FORCE MICROSCOPY  HEAVY-METALS  BIOMASS  IONS  IR