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浏览/检索结果: 共25条，第1-10条 帮助 限定条件 发表日期：2014    专题：北京大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Constructing the Energy Landscape for Genetic Switching System Driven by Intrinsic Noise 其他 2014-01-01 Lv, Cheng; Li, Xiaoguang; Li, Fangting; Li, Tiejun 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/10 POTENTIAL LANDSCAPE  ESCHERICHIA-COLI  EXIT PROBLEM  EXPRESSION  NETWORKS  PATHS  FATE   Redesigning the blue copper azurin into a redox-active mononuclear nonheme iron protein: Preparation and study of Fe(II)-M121E azurin 期刊论文 journal of the american chemical society, 2014 Liu, Jing; Meier, Katlyn K.; Tian, Shiliang; Zhang, Jun-Long; Guo, Hongchao; Schulz, Charles E.; Robinson, Howard; Nilges, Mark J.; M??nck, Eckard; Lu, Yi 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/12 Discovery of binding proteins for a protein target using protein-protein docking-based virtual screening 期刊论文 proteins structure function and bioinformatics, 2014 Zhang, Changsheng; Tang, Bo; Wang, Qian; Lai, Luhua 收藏  |  浏览/下载：2/0  |  提交时间：2015/11/13 protein-protein docking  virtual screening  protein design  protein-protein interaction prediction  binding energy landscape  TNF alpha  COMPUTATIONAL DESIGN  CRYSTAL-STRUCTURE  DRUG DESIGN  TNF-ALPHA  THERAPEUTICS  PERSPECTIVE  PREDICTION  SCAFFOLDS  EVOLUTION  BIOLOGY   Protein-Protein Interface Analysis and Hot Spots Identification for Chemical Ligand Design 期刊论文 current pharmaceutical design, 2014 Chen, Jing; Ma, Xiaomin; Yuan, Yaxia; Pei, Jianfeng; Lai, Luhua 收藏  |  浏览/下载：7/0  |  提交时间：2015/11/13 Protein-protein interface analysis  small molecular binder  binding site detection  ligandability  hot spots  Pocket V.3  SMALL-MOLECULE INHIBITORS  DRUG DISCOVERY  BINDING-SITES  CONFORMATIONAL DYNAMICS  STRUCTURAL BIOLOGY  TRANSIENT POCKETS  PREDICTION  ALLOSTERY  DRUGGABILITY  MODULATION   The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays 期刊论文 acta crystallographica section d biological crystallography, 2014 Cao, Qin; Wang, Xiao-Jun; Li, Lan-Fen; Su, Xiao-Dong 收藏  |  浏览/下载：4/0  |  提交时间：2015/11/13 MUTANT HUNTINGTIN  SELF-ACTIVATION  AMINO-ACID  IN-VIVO  CLEAVAGE  DEGENERATION  CONFORMATION  METHIONINE  PROTEINS  CASCADE   A protein engineered to bind uranyl selectively and with femtomolar affinity 期刊论文 nature chemistry, 2014 Zhou, Lu; Bosscher, Mike; Zhang, Changsheng; Oezcubukcu, Salih; Zhang, Liang; Zhang, Wen; Li, Charles J.; Liu, Jianzhao; Jensen, Mark P.; Lai, Luhua; He, Chuan 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/13 COORDINATION CHEMISTRY  ENZYME DESIGN  SEA-WATER  URANIUM  EXTRACTION  SEAWATER  ION  METALLOPROTEINS  FORMS   Copper-sulfenate complex from oxidation of a cavity mutant of Pseudomonas aeruginosa azurin 期刊论文 proceedings of the national academy of sciences of the united states of america, 2014 Sieracki, Nathan A.; Tian, Shiliang; Hadt, Ryan G.; Zhang, Jun-Long; Woertink, Julia S.; Nilges, Mark J.; Sun, Furong; Solomon, Edward I.; Lu, Yi 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/16 bioinorganic chemistry  metalloprotein design  protein engineering  blue copper proteins  posttranslational modification  NITRILE HYDRATASE  CRYSTAL-STRUCTURES  REDOX REGULATION  CYSTEINE  ACID  PROTEINS  METAL  BINDING  SITE  METALLOPROTEINS   绿色荧光蛋白的原核表达和纯化及鉴定的实验设计与实践 期刊论文 实验技术与管理, 2014 王青松; 胡晓倩 收藏  |  浏览/下载：1/0  |  提交时间：2015/10/23 绿色荧光蛋白  亲和纯化  SDS-PAGE电泳  LC-MS/MS质谱  Western blotting  green fluorescent protein(GFP)  affinity chromatography  SDS-PAGE  Western blotting  LC-MS/MS   Design of Novel PLK1 Inhibitors 其他 2014-01-01 云泰康翔; 覃覃; 陈芳进; 刘莹; 来鲁华 收藏  |  浏览/下载：1/0  |  提交时间：2015/10/23 PLK1 Inhibitor Domain-domain interface   A systematic study of chemogenomics of carbohydrates 期刊论文 分子生物系统, 2014 Gu, Jiangyong; Luo, Fang; Chen, Lirong; Yuan, Gu; Xu, Xiaojie 收藏  |  浏览/下载：5/0  |  提交时间：2015/11/10 DRUG DISCOVERY  CHEMICAL SPACE  NETWORK PHARMACOLOGY  POLYPHARMACOLOGY  BIOLOGY  DESIGN  MEDICINES  RESPONSES