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	Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications
	Liu, Qiuju1,2,3,6,7; Sun, Liang4,5; Tan, Yi1,2,3; Wang, Guanjun6; Lin, Xu4,5; Cai, Lu1,2,3,6
刊名	Current medicinal chemistry
	2009
卷号	16期号:1页码:113-129
关键词	Diabetes Diabetic complications Insulin resistance Iron deficiency Iron overload Iron Ferritin Anemia
ISSN号	0929-8673
通讯作者	Lin, xu(xlin@sibs.ac.cn)
英文摘要	Iron is one of the essential minerals that are required for a variety of molecules to maintain their normal structures and functions and for cells to live, grow, and proliferate. the homeostasis of iron results from a tightly coordinated regulation by different proteins involved in uptake, excretion and intracellular storage/trafficking. although it is essential, iron can also be toxic once in excess amounts. through fenton reaction, iron as a transit mineral can generate various reactive oxygen or nitrogen species; therefore, abnormal metabolism of iron can lead to several chronic pathogenesis. oxidative stress is one of the major causative factors for diabetes and diabetic complications. increasing evidence has indicated that iron overload not only increases risks of insulin resistance and diabetes, but also causes cardiovascular diseases in non-diabetic and diabetic subjects. temporal iron deficiency was found to sensitize insulin action, but chronic iron deficiency with anemia can accelerate the development of cardiovascular diseases in non-diabetic and diabetic patients. in this review, therefore, we will first outline iron homeostasis, function, and toxicity, and then mainly summarize the data regarding the roles of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications, as well as the possible links of iron to diabetes and diabetic complications. in the end, the possible therapy using iron chelators for diabetes and diabetic complications will also be discussed.
WOS关键词	INSULIN-RESISTANCE SYNDROME ; BETA-THALASSEMIA MAJOR ; MITOCHONDRIAL-MEMBRANE PROTEIN ; VOLUNTARY BLOOD-DONORS ; CORONARY-HEART-DISEASE ; SERUM FERRITIN ; ANGIOTENSIN-II ; HEME OXYGENASE ; GLUCOSE-METABOLISM ; UP-REGULATION
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000263294600006
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2402527
专题	中国科学院大学
通讯作者	Lin, Xu
作者单位	1.Univ Louisville, Dept Med, Louisville, KY 40292 USA 2.Univ Louisville, Dept Radiat Oncol, Louisville, KY 40292 USA 3.Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China 5.Chinese Acad Sci, Grad Univ, Shanghai, Peoples R China 6.Jilin Univ, Hosp 1, Changchun 130023, Peoples R China 7.Jilin Univ, Hosp 2, Changchun 130023, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qiuju,Sun, Liang,Tan, Yi,et al. Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications[J]. Current medicinal chemistry,2009,16(1):113-129.
APA	Liu, Qiuju,Sun, Liang,Tan, Yi,Wang, Guanjun,Lin, Xu,&Cai, Lu.(2009).Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications.Current medicinal chemistry,16(1),113-129.
MLA	Liu, Qiuju,et al."Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications".Current medicinal chemistry 16.1(2009):113-129.

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