Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications | |
Liu, Qiuju1,2,3,6,7; Sun, Liang4,5; Tan, Yi1,2,3; Wang, Guanjun6; Lin, Xu4,5; Cai, Lu1,2,3,6 | |
刊名 | Current medicinal chemistry |
2009 | |
卷号 | 16期号:1页码:113-129 |
关键词 | Diabetes Diabetic complications Insulin resistance Iron deficiency Iron overload Iron Ferritin Anemia |
ISSN号 | 0929-8673 |
通讯作者 | Lin, xu(xlin@sibs.ac.cn) |
英文摘要 | Iron is one of the essential minerals that are required for a variety of molecules to maintain their normal structures and functions and for cells to live, grow, and proliferate. the homeostasis of iron results from a tightly coordinated regulation by different proteins involved in uptake, excretion and intracellular storage/trafficking. although it is essential, iron can also be toxic once in excess amounts. through fenton reaction, iron as a transit mineral can generate various reactive oxygen or nitrogen species; therefore, abnormal metabolism of iron can lead to several chronic pathogenesis. oxidative stress is one of the major causative factors for diabetes and diabetic complications. increasing evidence has indicated that iron overload not only increases risks of insulin resistance and diabetes, but also causes cardiovascular diseases in non-diabetic and diabetic subjects. temporal iron deficiency was found to sensitize insulin action, but chronic iron deficiency with anemia can accelerate the development of cardiovascular diseases in non-diabetic and diabetic patients. in this review, therefore, we will first outline iron homeostasis, function, and toxicity, and then mainly summarize the data regarding the roles of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications, as well as the possible links of iron to diabetes and diabetic complications. in the end, the possible therapy using iron chelators for diabetes and diabetic complications will also be discussed. |
WOS关键词 | INSULIN-RESISTANCE SYNDROME ; BETA-THALASSEMIA MAJOR ; MITOCHONDRIAL-MEMBRANE PROTEIN ; VOLUNTARY BLOOD-DONORS ; CORONARY-HEART-DISEASE ; SERUM FERRITIN ; ANGIOTENSIN-II ; HEME OXYGENASE ; GLUCOSE-METABOLISM ; UP-REGULATION |
WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | BENTHAM SCIENCE PUBL LTD |
WOS记录号 | WOS:000263294600006 |
内容类型 | 期刊论文 |
URI标识 | http://www.corc.org.cn/handle/1471x/2402527 |
专题 | 中国科学院大学 |
通讯作者 | Lin, Xu |
作者单位 | 1.Univ Louisville, Dept Med, Louisville, KY 40292 USA 2.Univ Louisville, Dept Radiat Oncol, Louisville, KY 40292 USA 3.Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China 5.Chinese Acad Sci, Grad Univ, Shanghai, Peoples R China 6.Jilin Univ, Hosp 1, Changchun 130023, Peoples R China 7.Jilin Univ, Hosp 2, Changchun 130023, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Qiuju,Sun, Liang,Tan, Yi,et al. Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications[J]. Current medicinal chemistry,2009,16(1):113-129. |
APA | Liu, Qiuju,Sun, Liang,Tan, Yi,Wang, Guanjun,Lin, Xu,&Cai, Lu.(2009).Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications.Current medicinal chemistry,16(1),113-129. |
MLA | Liu, Qiuju,et al."Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications".Current medicinal chemistry 16.1(2009):113-129. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论