Polymeric nanoparticles promote macrophage reversal from m2 to m1 phenotypes in the tumor microenvironment | |
Wang, Yi1,2; Lin, Yao-Xin1,2; Qiao, Sheng-Lin1,2; An, Hong-Wei1,2; Ma, Yang1,2; Qiao, Zeng-Ying1; Rajapaksha, R. P. Yeshan J.1,2; Wang, Hao1,2 | |
刊名 | Biomaterials |
2017 | |
卷号 | 112页码:153-163 |
关键词 | Nanoparticles Self-assembly Cancer Immunotherapy Macrophage |
ISSN号 | 0142-9612 |
DOI | 10.1016/j.biomaterials.2016.09.034 |
通讯作者 | Wang, hao(wanghao@nanoctr.cn) |
英文摘要 | Immunotherapy has shown promising treatment effects for a variety of cancers. however, the immune treatment efficiency for solid tumors is limited owing to insufficient infiltration of immune cells into solid tumors. the conversion of tumor-supportive macrophages to tumor-suppressive macrophages, inducing the functional reversal of macrophages, is an effective method and contributes to a subsequent antitumor response. the current challenge in the field is the poor distribution and systemic side effects associated with the use of cytokines. as a solution to this issue, we designed and synthesized microenvironment-responsive nanoparticles (p) with il-12 payload (il-12 subset of p1). these nanoparticles could promote the systemic administration and release of il-12 in the tumor microenvironment, and the locally responsive property of il-12 subset of p1 could subsequently re-educate tumor-associated macrophages (tams). in particular, our results illustrated the great therapeutic effects derived from the functional conversion of macrophages. our strategy was to design a microenvironment-responsive material for local macrophage modification to overcome the physiological barrier of solid tumors. the shifting of macrophage phenotypes via il-12 subset of p1 achieved immunomodulation in the microenvironment for cancer therapy, with negligible cytotoxicity. we expect that the functional regulation of tams by ph-responsive nanomaterials is a promising therapeutic approach for cancer immunotherapy. (c) 2016 elsevier ltd. all rights reserved. |
WOS关键词 | ANTIGEN-PRESENTING CELLS ; CANCER-IMMUNOTHERAPY ; IN-VIVO ; ADAPTIVE IMMUNITY ; DENDRITIC CELLS ; ACTIVATION ; DELIVERY ; PH ; RESISTANCE ; ANTITUMOR |
WOS研究方向 | Engineering ; Materials Science |
WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000389166700014 |
内容类型 | 期刊论文 |
URI标识 | http://www.corc.org.cn/handle/1471x/2176620 |
专题 | 高能物理研究所 |
通讯作者 | Wang, Hao |
作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, 11 Beiyitiao, Beijing, Peoples R China 2.Univ Chinese Acad Sci UCAS, 19A Yuquan Rd, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yi,Lin, Yao-Xin,Qiao, Sheng-Lin,et al. Polymeric nanoparticles promote macrophage reversal from m2 to m1 phenotypes in the tumor microenvironment[J]. Biomaterials,2017,112:153-163. |
APA | Wang, Yi.,Lin, Yao-Xin.,Qiao, Sheng-Lin.,An, Hong-Wei.,Ma, Yang.,...&Wang, Hao.(2017).Polymeric nanoparticles promote macrophage reversal from m2 to m1 phenotypes in the tumor microenvironment.Biomaterials,112,153-163. |
MLA | Wang, Yi,et al."Polymeric nanoparticles promote macrophage reversal from m2 to m1 phenotypes in the tumor microenvironment".Biomaterials 112(2017):153-163. |
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