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浏览/检索结果: 共6条，第1-6条 帮助 限定条件 专题：中南大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 MiR-150 regulates human keratinocyte proliferation in hypoxic conditions through targeting HIF-1alpha and VEGFA: Implications for psoriasis treatment. 期刊论文 PLOS ONE, 2017, 卷号: 12, 期号: 4, 页码: e0175459 作者:  Li, Yongjian;  Su, Juan 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03 Psoriasis,Keratinocytes,MicroRNAs,Cell proliferation,Protein expression,3' UTR,Hypoxia,Skin tissue   Heterogeneous network model to infer human disease-long intergenic non-coding RNA associations 期刊论文 IEEE Transactions on Nanobioscience, 2015, 卷号: 14, 期号: 2, 页码: 175-183 作者:  Ganegoda, Gamage Upeksha;  Li, Min;  Wang, Weiping;  Feng, Qilong* 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03 Gaussian interaction profile kernel  heterogeneous network  long non-coding RNAs  tissue expression   MicroRNA-20b and ERK1/2 pathway independently regulate the expression of tissue factor in hematopoietic and trophoblastic differentiation of human embryonic stem cells 期刊论文 Stem Cell Research & Therapy, 2013, 卷号: 4, 期号: 5, 页码: 121 作者:  Yan-Hui Yu;  Deng-Shu Wu;  Fang-Fang Huang;  Zheng Zhang;  Lin-Xin Liu 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03 Human Embryonic Stem Cell  Magnetic Activate Cell Sorting  Tissue Factor  Tissue Factor Expression  Trophoblastic Differentiation   Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文 International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118 作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03 DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.   Gene expression profile analysis of human hepatocellular carcinoma using SAGE and LongSAGE 期刊论文 BMC Medical Genomics, 2009, 卷号: 2, 期号: 1, 页码: 5 作者:  Hui Dong;  Xijin Ge;  Yan Shen;  Linlei Chen;  Yalin Kong 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 Adjacent Nontumorous Liver  Liver Cancer Cell Line HepG2  LongSAGE Library  Nontumorous Liver Tissue  Public Gene Expression Omnibus Database   Proteome analysis of human lung squamous carcinoma 期刊论文 PROTEOMICS, 2006, 卷号: 6, 期号: 2, 页码: 547-558 作者:  Li, Cui;  Xiao, Zhiqiang;  Chen, Zhuchu;  Zhang, Xiaopeng;  Li, Jianling 收藏  |  浏览/下载：7/0  |  提交时间：2019/12/03 Differential expression protein  Human lung squamous carcinoma tissue  Normal bronchial epithelial tissue  Proteome analysis  Serological proteome analysis