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科研机构
上海药物研究所 [920]
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期刊论文 [908]
会议论文 [11]
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Nitrogenous Sesquiterpenoids from the South China Sea Nudibranch Hexabranchus sanguineus and Its Possible Sponge-Prey Acanthella cavernosa: Chiral Separation, Stereochemistry and Chemical Ecology
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2022, 卷号: 40, 期号: 2, 页码: 235-246
作者:
Shen, Shou-Mao
;
Zhang, Zai-Yong
;
Yao, Li-Gong
;
Wang, Jian-Rong
;
Guo, Yue-Wei
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/01/18
Hexabranchus sanguineus
Acanthella cavernosa
Chiral separation
Stereochemistry
Chemical ecology
New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2022, 卷号: 40, 期号: 1, 页码: 28-38
作者:
Lin, Na
;
Li, Heng
;
Wang, Jian-Rong
;
Tang, Wei
;
Zheng, Ming-Yue
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/01/04
Sinularia nanolobata
Cembranoids
X-ray diffraction
Configuration determination
Natural products
Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2022, 卷号: 40, 期号: 1, 页码: 79-90
作者:
Li, Jin-Feng
;
Zeng, Yan-Bo
;
Li, Wang-Sheng
;
Luo, Hui
;
Zhang, Hai-Yan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/01/04
Sarcophyton glaucum
Cembranoids
Configuration determination
X-ray diffraction
NMR spectroscopy
Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy
期刊论文
Journal of Nanobiotechnology, 2021, 卷号: 19, 期号: 1
作者:
Shi,Junyu
;
Zhang,Yi
;
Zhang,Xiaomeng
;
Chen,Ruiying
;
Wei,Jianxu
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2022/01/04
Resveratrol
Macrophage
Periodontitis
Liposome
Immune microenvironment
Local delivery
A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11
作者:
Cheng, Zhiyang
;
Huang, Ying
;
Shen, Qianqian
;
Zhao, Yangrong
;
Wang, Lei
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
Cancer
beta-glucuronidase
Bioconjugation
Albumin
Camptothecin
GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhang, Qing
;
Chen, Lin-hai
;
Yang, Hui
;
Fang, You-chen
;
Wang, Si-wei
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2022/01/18
GPR84
medium chain fatty acid receptor
GPCR
inflammatory bowel diseases
ulcerative colitis
NLRP3 inflammasome
macrophages
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Wu, Bing
;
Xu, Meng-meng
;
Fan, Chen
;
Feng, Chun-lan
;
Lu, Qiu-kai
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2022/01/18
acute lung injury
STING
vascular endothelial cells
inflammatory cytokines
chemokines
chemotaxis
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Advancing COVID-19 diagnosis with privacy-preserving collaboration in artificial intelligence
期刊论文
NATURE MACHINE INTELLIGENCE, 2021, 卷号: 3, 期号: 12, 页码: 1081-1089
作者:
Bai, Xiangd
;
Wang, Hanchen
;
Ma, Liya
;
Xu, Yongchao
;
Gan, Jiefeng
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2022/01/18
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
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