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科研机构
上海药物研究所 [108]
内容类型
期刊论文 [107]
会议论文 [1]
发表日期
2021 [6]
2020 [8]
2019 [8]
2018 [10]
2017 [8]
2016 [14]
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Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/18
Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 38, 页码: 11303-11310
作者:
Cheng, Jin-Tao
;
Wang, Han-Min
;
Yu, Jia-Hui
;
Sun, Chen-Fan
;
Cao, Fei
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
fungus
Calcarisporium arbuscula
natural product
gene cluster activation
liver fibrosis
Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa
期刊论文
SCIENCE BULLETIN, 2021, 卷号: 66, 期号: 11, 页码: 1101-1118
作者:
Wang, Yaya
;
Cao, Qiao
;
Cao, Qin
;
Gan, Jianhua
;
Sun, Ning
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
Pseudomonas aeruginosa
Histamine
Metabolism
Host-microbe interaction
Virulence
Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 37, 页码: 16
作者:
Yang, Gui-Xiang
;
Sun, Jia-Min
;
Zheng, Lu-Lu
;
Zhang, Li
;
Li, Jie
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/06/11
Vascular dementia
Diosgenin
Antioxidant
Anti-cholinesterase
Multi-target-directed ligands
(-)-Isoscopariusin A, a Naturally Occurring Immunosuppressive Meroditerpenoid: Structure Elucidation and Scalable Chemical Synthesis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 10
作者:
Yan, Bing-Chao
;
Zhou, Min
;
Li, Jian
;
Li, Xiao-Nian
;
He, Shi-Jun
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2021/05/24
bioactivity
cyclobutane
natural products
scalable synthesis
structure elucidation
Reply to: Binding site for MDL-801 on SIRT6
期刊论文
NATURE CHEMICAL BIOLOGY, 2021, 页码: 5
作者:
Huang, Zhimin
;
Zhao, Junxing
;
Deng, Wei
;
Chen, Yingyi
;
Shang, Jialin
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2021/05/24
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
A new method for the synthesis of chalcone derivatives promoted by PPh3/I(2)under non-alkaline conditions
期刊论文
SYNTHETIC COMMUNICATIONS, 2020, 页码: 10
作者:
Xue, Kangsheng
;
Sun, Guoxiang
;
Zhang, Yanzhi
;
Chen, Xubing
;
Zhou, Yang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/24
Aldehyde
chalcone
Claisen-Schmidt reaction
ketone
PPh3
I2
PPh3/I-2-catalyzed one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones
期刊论文
SYNTHETIC COMMUNICATIONS, 2020, 页码: 8
作者:
Zhang, Yanzhi
;
Lei, Min
;
Xue, Kangsheng
;
Sun, Guoxiang
;
Zhou, Yang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/12/21
46-diarylpyrimidin-2-(1H)-ones
PPh3
I2
Aldehyde
Ketone
Biginelli reaction
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
期刊论文
CANCER CELL, 2020, 卷号: 38, 期号: 1, 页码: 79-+
作者:
Su, Rui
;
Dong, Lei
;
Li, Yangchan
;
Gao, Min
;
Han, Li
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/12/24
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