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科研机构
上海药物研究所 [12]
内容类型
期刊论文 [12]
发表日期
2021 [1]
2020 [1]
2018 [2]
2017 [3]
2015 [1]
2012 [2]
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Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 7
作者:
Wang, Yi
;
Fang, Sui
;
Wu, Yan
;
Cheng, Xi
;
Zhang, Lei-ke
收藏
  |  
浏览/下载:103/0
  |  
提交时间:2021/08/17
SARS-CoV-2
envelope protein (2-E)
cation channel
high-throughput screening (HTS)
anti-virus
RIPK1 inhibitor ameliorates colitis by directly maintaining intestinal barrier homeostasis and regulating following IECs-immuno crosstalk
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 172, 页码: 16
作者:
Lu, Huimin
;
Li, Heng
;
Fan, Chen
;
Qi, Qing
;
Yan, Yuxi
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
RIPK1 inhibitor
Colitis
Barrier homeostasis
IECs-immunocytes crosstalk
Necroptosis
NF-kappa B
Human pharmacokinetics of ginkgo terpene lactones and impact of carboxylation in blood on their platelet-activating factor antagonistic activity
期刊论文
Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1935-1946
作者:
Liu, Xin-Wei
;
Yang, Jun-Ling
;
Niu, Wei
;
Jia, Wei-Wei
;
Olaleye, Olajide E
收藏
  |  
浏览/下载:104/0
  |  
提交时间:2019/01/08
Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3K alpha-selective inhibitor CYH33 in breast cancer
期刊论文
CANCER LETTERS, 2018, 卷号: 433, 页码: 273-282
作者:
Liu, Xue-ling
;
Xu, Yi-chao
;
Wang, Yu-xiang
;
Chen, Yi
;
Wang, Bo-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
PIK3CA
HER2
Akt
Patient-derived xenograft (PDX)
New Cytotoxic Secondary Metabolites from Marine Bryozoan Cryptosula pallasiana
期刊论文
Marine drugs, 2017, 卷号: 15, 期号: 4
作者:
Tian, Xiang-Rong
;
Gao, Yan-Qing
;
Tian, Xiao-Lin
;
Li, Jiao
;
Tang, Hai-Feng
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials
期刊论文
CANCER LETTERS, 2017, 卷号: 386, 页码: 47-56
作者:
Yuan, Bo
;
Ye, Na
;
Song, Shan-Shan
;
Wang, Yu-Ting
;
Song, Zilan
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Homologous recombination repair defects
Olaparib
Growth inhibition
Patient-derived xenografts
Pharmacokinetics
Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 4156-4168
作者:
He, Jin-Xue
;
Wang, Meng
;
Huan, Xia-Juan
;
Chen, Chuan-Huizi
;
Song, Shan-Shan
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
MPH
PARP inhibitor
homologous recombination
antitumor activity
synthetic lethality
Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen)
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 5, 页码: 627-643
作者:
Tian, Dan-dan
;
Jia, Wei-wei
;
Liu, Xin-wei
;
Wang, Dan-dan
;
Liu, Jun-hua
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
tanshinol
methylation
catechol-O-methyltransferase
herb-drug interaction
Salvia miltiorrhiza roots
Danshen
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 24, 页码: 7440-7443
作者:
Dai, Hou-ling
;
Gao, Li-xin
;
Yang, Ying
;
Li, Jing-ya
;
Cheng, Jia-gao
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B
Molecular docking
Inhibitors
Di-indolinone
A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities
期刊论文
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 2, 页码: 148-154
作者:
He, Min
;
Guan, Ni
;
Gao, Wei-wei
;
Liu, Qing
;
Wu, Xiao-yan
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
type 2 diabetes
glucagon-like peptide-1
non-peptidic agonist
Boc5
G-protein coupled receptor
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