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科研机构
上海药物研究所 [11]
内容类型
期刊论文 [11]
发表日期
2020 [2]
2018 [1]
2017 [1]
2016 [1]
2015 [2]
2014 [1]
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Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Su, Hai-xia
;
Yao, Sheng
;
Zhao, Wen-feng
;
Li, Min-jun
;
Liu, Jia
收藏
  |  
浏览/下载:118/0
  |  
提交时间:2020/12/24
SARS-CoV-2
3CL protease
traditional Chinese medicines
Shuanghuanglian oral liquid
baicalin
baicalein
Hepatoprotective effects of total phenylethanoid glycosides from Acanthus ilicifolius L. against carbon tetrachloride-induced hepatotoxicity
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 卷号: 256, 页码: 8
作者:
Zhang, Meng-Qi
;
Ren, Xia
;
Zhao, Qing
;
Yue, Shi-Jun
;
Fu, Xiu-Mei
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
Acanthus ilicifolius L.
Total phenylethanoid glycosides
Hepatoprotective
Antioxidant
Metabolism and disposition of pyrotinib in healthy male volunteers: covalent binding with human plasma protein
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Meng, Jian
;
Liu, Xiao-Yun
;
Ma, Sheng
;
Zhang, Hua
;
Yu, Song-da
收藏
  |  
浏览/下载:101/0
  |  
提交时间:2019/01/08
Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 4156-4168
作者:
He, Jin-Xue
;
Wang, Meng
;
Huan, Xia-Juan
;
Chen, Chuan-Huizi
;
Song, Shan-Shan
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
MPH
PARP inhibitor
homologous recombination
antitumor activity
synthetic lethality
Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 5, 页码: 698-707
作者:
Liu, Tong-chao
;
Peng, Xia
;
Ma, Yu-chi
;
Ji, Yin-chun
;
Chen, Dan-qi
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
c-Met inhibitors
hepatocyte growth factor receptor
imidazo[1,2-a]pyridine
anticancer agents
drug discovery
Dual targeting of microtubule and topoisomerase II by alpha-carboline derivative YCH337 for tumor proliferation and growth inhibition
期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 11, 页码: 8960-8973
作者:
Yi, Jun-Mei
;
Zhang, Xiao-Fei
;
Huan, Xia-Juan
;
Song, Shan-Shan
;
Wang, Wei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
YCH337
alpha-carboline derivative
microtubule
topoisomerase II
antitumor activity
2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 4, 页码: 483-496
作者:
Zhang, Jin
;
Zhang, Li-na
;
Chen, Dong-mei
;
Fu, Yan-yun
;
Zhang, Feng
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylic acid
lipogenesis
SREBP-1c
AMPK
mTOR
hepatic lipid accumulation
obesity
metabolic disorders
MCL-1 Degradation Mediated by JNK Activation via MEKK1/TAK1-MKK4 Contributes to Anticancer Activity of New Tubulin Inhibitor MT189
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2014, 卷号: 13, 期号: 6, 页码: 1480-1491
作者:
Wang, Wei
;
Wang, Ying-Qing
;
Meng, Tao
;
Yi, Jun-Mei
;
Huan, Xia-Juan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Effects of the novel vascular targeting agent MDS-11P on tumor vascularity and its antitumor activity
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2011, 卷号: 82, 期号: 12, 页码: 1832-1842
作者:
Deng, Zhi-Ting
;
Feng, Teng
;
Wang, Peng
;
Qi, Xin
;
Chen, Xue-Hong
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Vascular disrupting agents
MDS-11P
Antitumor
CA4 derivative
Vascularity
Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication
期刊论文
FASEB JOURNAL, 2010, 卷号: 24, 期号: 1, 页码: 196-205
作者:
Xie, Yuan-Yuan
;
Zhou, Chen-Jie
;
Zhou, Zi-Ren
;
Hong, Jing
;
Che, Mei-Xia
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2019/01/08
coiled coil
solution structure
Parkinson's disease
Lewy body
dimerization
N-terminal stretch
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