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科研机构
上海药物研究所 [168]
内容类型
期刊论文 [163]
会议论文 [5]
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2021 [11]
2020 [16]
2019 [8]
2018 [18]
2017 [10]
2016 [11]
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GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhang, Qing
;
Chen, Lin-hai
;
Yang, Hui
;
Fang, You-chen
;
Wang, Si-wei
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2022/01/18
GPR84
medium chain fatty acid receptor
GPCR
inflammatory bowel diseases
ulcerative colitis
NLRP3 inflammasome
macrophages
The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206
作者:
Jiang, Yuchen
;
Peng, Xia
;
Ji, Yinchun
;
Dai, Yang
;
Fang, Yanfen
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/16
The Novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis by Inhibiting the Notch Signaling Pathway
期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12, 页码: 15
作者:
Fu, Yadong
;
Xiao, Zhun
;
Tian, Xiaoting
;
Liu, Wei
;
Xu, Zhou
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/01/04
traditional Chinese medicine
JY5 formula
fuzheng huayu
hepatic fibrosis
notch signaling pathway
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Wang, Lin
;
Wu, Yan
;
Yao, Sheng
;
Ge, Huan
;
Zhu, Ya
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/11/04
SARS-CoV-2
natural products
virtual screening
spike protein
protein-protein interaction modulators
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
期刊论文
CELL RESEARCH, 2021, 页码: 14
作者:
Xia, Bingqing
;
Shen, Xurui
;
He, Yang
;
Pan, Xiaoyan
;
Liu, Feng-Liang
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2021/08/17
Simultaneous determination of forsythin and its major metabolites in human plasma via liquid chromatography-tandem mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7
作者:
Pan, Lu-lu
;
Chen, Tao
;
Hui, Min
;
Wang, Shuo
;
Fu, Li
收藏
  |  
浏览/下载:134/0
  |  
提交时间:2021/05/24
LC-MS/MS
Forsythin
Aglycone glucuronide
Aglycone sulfate
Pharmacokinetics
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 18
作者:
Lan, Xiao-fang
;
Olaleye, Olajide E.
;
Lu, Jun-lan
;
Yang, Wei
;
Du, Fei-fei
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  |  
浏览/下载:76/0
  |  
提交时间:2021/06/11
LianhuaQingwen
glycyrrhetic acid
24-hydroxyglycyrrhetic acid
Gancao-induced pseudoaldosteronism
licorice-induced pseudoaldosteronism
11β
-hydroxysteroid dehydrogenase 2
COVID-19
colonic microbiota
Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yong-zhen
;
Lu, Heng-lei
;
Qi, Xin-ming
;
Xing, Guo-zhen
;
Wang, Xin
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/05/24
aristolochic acid I
glutathione S-transferase placental form-positive foci
clonal expansion
hepatocellular carcinoma
medium-term rat liver bioassay
DNA adducts
Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 8
作者:
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Jiang, Jin-fang
;
Yang, Yong
;
Guo, Li-xia
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/05/24
Alflutinib
Rifampicin
CYP3A4
AST5902
Drug-drug interaction
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yu-ting
;
Ding, Hui-hua
;
Lin, Ze-min
;
Wang, Que
;
Chen, Li
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
rheumatoid arthritis
BTK inhibitors
B cells
macrophages
RANKL
osteoclastogenesis
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