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科研机构
上海药物研究所 [10]
内容类型
期刊论文 [10]
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2020 [1]
2016 [1]
2015 [1]
2014 [2]
2013 [4]
2003 [1]
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Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 9
作者:
Han, Jie
;
Tian, Yucheng
;
Yu, Liang
;
Zhang, Qilin
;
Xu, Xi
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2020/12/24
Ubiquitination
High throughput screening
Drug discovery
USP8
Effects of Different Formulations on Plasma Free Concentration of Paclitaxel in Rats
期刊论文
Chinese Journal of Pharmaceuticals, 2016, 卷号: 47, 期号: 11, 页码: 1430-1435
作者:
Wu Hailan
;
Ma Zhiyu
;
Zhang Shuqiu
;
Zhong Dafang
;
Chen Xiaoyan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
paclitaxel
Abraxane
Genexol-PM
Taxol
plasma-free fraction value
rapid equilibrium dialysis
LC-MS/MS
Structure-Activity Relationships and Anti-inflammatory Activities of N-Carbamothioylformamide Analogues as MIF Tautomerase Inhibitors
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2015, 卷号: 55, 期号: 9, 页码: 1994-2004
作者:
Zhang, Yu
;
Xu, Lei
;
Zhang, Zhiqiang
;
Zhang, Zhiyu
;
Zheng, Longtai
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumors
期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2014, 卷号: 7
作者:
Zhang, Jian
;
Cao, Junning
;
Li, Jin
;
Zhang, Yifan
;
Chen, Zhiyu
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
AST1306
ErbB family
Irreversible tyrosine kinase inhibitor
Phase I
Simultaneous determination of ornidazole and its main metabolites in human plasma by LC-MS/MS: application to a pharmacokinetic study
期刊论文
BIOANALYSIS, 2014, 卷号: 6, 期号: 18, 页码: 2343-2356
作者:
Du, Jiangbo
;
Ma, Zhiyu
;
Zhang, Yifan
;
Wang, Ting
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Enantioselective determination of ornidazole in human plasma by liquid chromatography-tandem mass spectrometry on a Chiral-AGP column
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2013, 卷号: 86, 页码: 182-188
作者:
Du, Jiangbo
;
Ma, Zhiyu
;
Zhang, Yifan
;
Wang, Ting
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Ornidazole
Enantiomers
Enantioselective liquid
chromatography-tandem mass spectrometry
Stereoselective pharmacokinetics
Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2013, 卷号: 939, 页码: 67-72
作者:
Diao, Xingxing
;
Ma, Zhiyu
;
Lei, Peng
;
Zhong, Dafang
;
Zhang, Yifan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
3-n-Butylphthalide (NBP)
Teicoplanin-based chiral column
LC-MS/MS
Enantioselective pharmacokinetics
Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS/MS using deuterated internal standards
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2013, 卷号: 78-79, 页码: 19-26
作者:
Diao, Xingxing
;
Ma, Zhiyu
;
Wang, Haidong
;
Zhong, Dafang
;
Zhang, Yifan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
3-n-Butylphthalide (NBP)
Deuterated internal standard
LC-MS/MS
Pharmacokinetics
Negative-positive ionization switching
Simultaneous determination of erdosteine and its active metabolite in human plasma by liquid chromatography-tandem mass spectrometry with pre-column derivatization
期刊论文
Acta Pharmaceutica Sinica, 2013, 卷号: 48, 期号: 3, 页码: 395-400
作者:
Jin Jing
;
Chen Xiaoyan
;
Zhang Yifan
;
Ma Zhiyu
;
Zhong Dafang
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
LC-MS/MS
erdosteine
pharmacokinetics
active metabolite
Chemical shift assignment of two chromone glycosides extracted from chinese herb anina pilulifera
期刊论文
Chinese Journal of Magnetic Resonance, 2003, 卷号: 20, 期号: 3, 页码: 265-269
作者:
Guo Yuewei
;
Huang Weihui
;
Song Guoqiang
;
Shao Zhiyu
;
Zhang Wen
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Undulatoside B
NMR
chromone glycoside
undulatoside B
5, 7-dihydroxy-2-methyl-chromone-7-O-beta-D-apiosyl (l6)-(3-D-Glucoside
chemical shift
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