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科研机构
上海药物研究所 [159]
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期刊论文 [158]
会议论文 [1]
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2022 [1]
2021 [23]
2020 [20]
2019 [9]
2018 [16]
2017 [10]
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Cipacinoids E-O: Eleven limonoids represent two different scaffolds from Cipadessa cinerascens
期刊论文
TETRAHEDRON, 2022, 卷号: 103, 页码: 11
作者:
Yu, Jin-Hai
;
Zhou, Bin
;
Wu, Pei-Qian
;
Liu, Qun-Fang
;
Yue, Jian-Min
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2022/01/04
Limonoids
Cipadessa cinerascen
Structural identification
Quantum-chemical calculation
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Wu, Bing
;
Xu, Meng-meng
;
Fan, Chen
;
Feng, Chun-lan
;
Lu, Qiu-kai
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2022/01/18
acute lung injury
STING
vascular endothelial cells
inflammatory cytokines
chemokines
chemotaxis
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC
Sulfoximines Assisted Rh(III)-Catalyzed C-H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines
期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 21, 页码: 15217-15227
作者:
Li, Jian
;
Li, Hui
;
Fang, Daqing
;
Liu, Lingjun
;
Han, Xu
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/01/04
Amygdalar k-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence
期刊论文
CELL REPORTS, 2021, 卷号: 37, 期号: 5, 页码: 21
作者:
Zan, Gui-Ying
;
Wang, Yu-Jun
;
Li, Xue-Ping
;
Fang, Jun-Fan
;
Yao, Song-Yu
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/12/16
Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 9, 页码: E264-E273
作者:
Chen, Zhen-dong
;
Chen, Qian
;
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Zhan, Yan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/04
henagliflozin
food effects
mass balance
pharmacokinetics
SGLT-2 inhibitor
Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 8
作者:
Fang, Feifei
;
Hu, Shulei
;
Li, Chunpu
;
Wang, Qian
;
Wang, Run
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/11/04
[n+1] annulation
C(sp(3))-H bond activation
N-N bond activation
pyrazolidinones
spiropyrazolones
Competitive CatSper Activators of Progesterone from Rhynchosia volubilis
期刊论文
PLANTA MEDICA, 2021, 页码: 10
作者:
Xiang, Jin
;
Kang, Hang
;
Li, Hong-Gang
;
Shi, Yu-Long
;
Zhang, Ya-Li
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/11/04
Leguminosae
Rhynchosia volubilis
CatSper
prenylated isoflavonoids
rhynchones A - E
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Wang, Lin
;
Wu, Yan
;
Yao, Sheng
;
Ge, Huan
;
Zhu, Ya
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2021/11/04
SARS-CoV-2
natural products
virtual screening
spike protein
protein-protein interaction modulators
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