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Structural Brain Abnormalities in Patients with Primary Open-Angle Glaucoma: A Study with 3T MR Imaging 期刊论文
2013, 卷号: 54, 期号: [db:dc_citation_issue], 页码: 545
作者:  Chen, Wei W.[1,2,3];  Wang, Ningli[1];  Cai, Suping[4];  Fang, Zhijia[5];  Yu, Man[2,3]
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/03
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  
Debris manipulation alters soil CO2 efflux in a subtropical plantation forest 期刊论文
GEODERMA, 2013, 页码: 316-322
作者:  Wang, Qingkui;  Liu, Suping;  Wang, Silong
收藏  |  浏览/下载：9/0  |  提交时间：2016/12/06
High power single mode 980 nm AlGaInAs/AlGaAs quantum well lasers with a very low threshold current 期刊论文
journal of semiconductors, 2013, 卷号: 34, 期号: 11, 页码: 114011
Zhen, Dong; Cuiluan, Wang; Hongqi, Jing; Suping, Liu; Xiaoyu, Ma
收藏  |  浏览/下载：18/0  |  提交时间：2014/04/30
Simulation and research on the automatic leveling of a precision stage 期刊论文
COMPUTER-AIDED DESIGN, 2013, 卷号: 45, 期号: [db:dc_citation_issue], 页码: 717-722
作者:  Liu, Yongsheng;  Fang, Suping;  Otsubo, Hisashi;  Sumida, Tsuneto
收藏  |  浏览/下载：5/0  |  提交时间：2019/12/10
Compensation method for the alignment angle error of a gear axis in profile deviation measurement 期刊论文
MEASUREMENT SCIENCE AND TECHNOLOGY, 2013, 卷号: 24, 期号: [db:dc_citation_issue]
作者:  Fang, Suping;  Liu, Yongsheng;  Wang, Huiyi;  Taguchi, Tetsuya;  Takeda, Ryuhei
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/10
Possible mechanism for the gastro-intestinal adverse effects upon topical application of Prostaglandin F-2 alpha analogs 期刊论文
2013, 卷号: 80, 期号: 1, 页码: 32
作者:  Cai, Suping[1,2,3,4];  Zhou, Xiaomin[1,2,3];  Yan, Naihong[1,2,3];  Liu, Xuyang[4];  Li, Xiaohong[5]
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/06
Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma 期刊论文
RESPIRATORY MEDICINE, 2013, 卷号: 107, 期号: 3
作者:  Nie, Hanxiang;  Zhang, Guqin;  Liu, Min;  Ding, Xuhong;  Huang, Yi
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/05
Cloning of ANS gene in Brassica nigra and PCR identification from Brassica B-genomes 期刊论文
Chinese Journal of Oil Crop Sciences, 2013, 卷号: Vol.35 No.5, 页码: 484-490
作者:  Yan Mingli;  Liu Lili;  Xiang Jianhua;  Ding Suping;  Shu Jiabin
收藏  |  浏览/下载：4/0  |  提交时间：2020/01/05
Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D 期刊论文
2013, 卷号: 79, 期号: 2, 页码: 104-110
作者:  Ling, Bing;  Zheng, Hongwei;  Fu, Guobin;  Yuan, Jingsong;  Shi, Taiping
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/13

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