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朱拉扎嘎金矿区地物光谱特征与地球化学成分之间的关系 期刊论文
中南大学学报. 自然科学版, 2013, 卷号: 44, 期号: 1, 页码: 266-274
作者:  丛丽娟;  岑况;  余学中;  黄增芳;  冷福荣
收藏  |  浏览/下载：4/0  |  提交时间：2018/11/12
2012年上海地区细菌耐药性监测 期刊论文
中国感染与化疗杂志, 2013, 期号: 6
作者:  张泓;  孔菁;  魏丽;  王金铎;  袁应华
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/05
中国10城市儿童哮喘及其他过敏性疾病现状调查 期刊论文
2013, 卷号: 58, 页码: 2504-2512
作者:  张寅平[1];  李百战[2];  黄晨[3];  杨旭[4];  钱华[5]
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/30
Effect of oxalic acid on ripening attributes of banana fruit during storage 期刊论文
2013, 卷号: 84, 期号: [db:dc_citation_issue], 页码: 22
作者:  Huang, Hua[1,2];  Jing, Guoxing[3];  Guo, Lifang[4];  Zhang, Dandan[1];  Yang, Bao[1]
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  
全国多中心类风湿关节炎患者残疾及功能受限情况的调查 期刊论文
中华风湿病学杂志, 2013, 卷号: 17, 期号: 8, 页码: 526-532
作者:  周云杉;  王秀茹;  安媛;  李春;  张晓盈
收藏  |  浏览/下载：47/0  |  提交时间：2016/09/13
纳米CeO2催化氧化甲苯的形貌效应研究 期刊论文
《环境科学学报》, 2013, 卷号: 33, 页码: 2412-2421
作者:  何丽芳[1];  廖银念[1,2];  陈礼敏[1];  付名利[1];  吴军良[1]
收藏  |  浏览/下载：2/0  |  提交时间：2019/04/25
A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet (Setaria italica) 期刊论文
NATURE GENETICS, 2013, 卷号: 45, 期号: 8, 页码: 957-U167
作者:  Jia, Guanqing;  Huang, Xuehui;  Zhi, Hui;  Zhao, Yan;  Zhao, Qiang
收藏  |  浏览/下载：5/0  |  提交时间：2016/12/05
Improved measurement of electron antineutrino disappearance at Daya Bay 期刊论文
2013, 期号: 1, 页码: 1-20
作者:  An FP(安丰鹏);  An Q(安琪);  Bai JZ(白景芝);  A.B.Balantekin;  H.R.Band
收藏  |  浏览/下载：38/0  |  提交时间：2019/12/09
医患沟通模拟训练在产科教学中的作用 期刊论文
中国高等医学教育, 2013, 期号: [db:dc_citation_issue], 页码: 79-80
作者:  侯萌;  李春芳;  黄谱;  张丽瑞;  雷春梅
收藏  |  浏览/下载：1/0  |  提交时间：2019/12/10

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