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Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990
作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin
收藏  |  浏览/下载:29/0  |  提交时间:2019/01/08
Aspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition 期刊论文
CANCER LETTERS, 2017, 卷号: 406, 页码: 105-115
作者:  Sun, Danni;  Liu, Hongchun;  Dai, Xiaoyang;  Zheng, Xingling;  Yan, Juan
收藏  |  浏览/下载:47/0  |  提交时间:2019/01/08
Isoastragaloside I inhibits NF-κB activation and inflammatory responses in BV-2 microglial cells stimulated with lipopolysaccharide 期刊论文
International journal of molecular medicine, 2017, 卷号: 40, 期号: 4, 页码: 1270-1276
作者:  Liu, Hongshuai;  Huang, Fei;  Wu, Hui;  Zhang, Beibei;  Shi, Hailian
收藏  |  浏览/下载:23/0  |  提交时间:2019/01/08
Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity 期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 8, 期号: 8, 页码: 875-880
作者:  Yang, Chengbin;  Zhang, Xi;  Wang, Yi;  Yang, Yongtai;  Liu, Xiaofeng
收藏  |  浏览/下载:28/0  |  提交时间:2019/01/08
DMT efficiently inhibits hepatic gluconeogenesis by regulating the G alpha q signaling pathway 期刊论文
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2017, 卷号: 59, 期号: 2, 页码: 151-169
作者:  Zhou, Ting-Ting;  Ma, Fei;  Shi, Xiao-Fan;  Xu, Xin;  Du, Te
收藏  |  浏览/下载:33/0  |  提交时间:2019/01/08
AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 489, 期号: 1, 页码: 14-20
作者:  Wang, Hongbin;  Quan, Haitian;  Lou, Liguang
收藏  |  浏览/下载:26/0  |  提交时间:2019/01/08
Puquitinib, a novel orally available PI3K inhibitor, exhibits potent antitumor efficacy against acute myeloid leukemia 期刊论文
CANCER SCIENCE, 2017, 卷号: 108, 期号: 7, 页码: 1476-1484
作者:  Xie, Chengying;  He, Ye;  Zhen, Mingyue;  Wang, Yulan;  Xu, Yongping
收藏  |  浏览/下载:18/0  |  提交时间:2019/01/08
Sulfated Hetero-Polysaccharides Protect SH-SY5Y Cells from H2O2-Induced Apoptosis by Affecting the PI3K/Akt Signaling Pathway 期刊论文
MARINE DRUGS, 2017, 卷号: 15, 期号: 4
作者:  Wang, Jing;  Liu, Huaide;  Zhang, Xuan;  Li, Xinpeng;  Geng, Lihua
收藏  |  浏览/下载:25/0  |  提交时间:2017/10/09
FoxO3对Keap1-Nrf2信号通路的调控及其在胆管癌肿瘤生长及耐药中的分子机制的研究 学位论文
2017, 2016
管丽
收藏  |  浏览/下载:8/0  |  提交时间:2017/06/20
SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3K delta) inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 1156-1171
作者:  Wei, Manman;  Zhang, Xi;  Wang, Xiang;  Song, Zilan;  Ding, Jian
收藏  |  浏览/下载:17/0  |  提交时间:2019/01/08


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