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科研机构
南华大学 [2]
北京大学 [2]
上海药物研究所 [2]
武汉轻工大学 [2]
西安交通大学 [1]
深圳先进技术研究院 [1]
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内容类型
期刊论文 [11]
发表日期
2016 [11]
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An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 21, 页码: 9575-9598
作者:
Wang, Ying-Qing
;
Wang, Ping-Yuan
;
Wang, Yu-Ting
;
Yang, Guang-Fu
;
Zhang, Ao
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 67071-67086
作者:
Qian, Jianchang
;
Chen, Yaqing
;
Meng, Tao
;
Ma, Lanping
;
Meng, Lanfang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
mTOR kinase inhibitor
mTORC2
apoptosis
lipid metabolism
Synergistic Therapy of Doxorubicin and miR-129-5p with Self-Cross-Linked Bioreducible Polypeptide Nanoparticles Reverses Multidrug Resistance in Cancer Cells
期刊论文
BIOMACROMOLECULES, 2016
作者:
Yi, Huqiang
;
Liu, Lanlan
;
Sheng, Nan
;
Li, Ping
;
Pan, Hong
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2017/01/16
Down-Regulation of the Cyclin-Dependent Kinase Inhibitor p57 Is Mediated by Jab1/Csn5 in Hepatocarcinogenesis
期刊论文
HEPATOLOGY, 2016, 卷号: 63, 期号: [db:dc_citation_issue], 页码: 898-913
作者:
Guo, Hui
;
Jing, Li
;
Cheng, Yangzi
;
Atsaves, Vassilis
;
Lv, Yi
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/02
A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells
期刊论文
PLOS ONE, 2016
Cao, Lili
;
Zhang, Lijun
;
Zhao, Xiang
;
Zhang, Ye
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2017/12/04
CANCER-CELLS
TUBULIN POLYMERIZATION
BIOLOGICAL EVALUATION
MUTATIONAL LANDSCAPE
MOLECULAR THERAPIES
ANTITUBULIN AGENTS
IN-VIVO
NUCLEOLIN
KINASE
IDENTIFICATION
Identification of YPL014W (Cip1) as a novel negative regulator of cyclin-dependent kinase in Saccharomyces cerevisiae
期刊论文
GENES TO CELLS, 2016
Ren, Ping
;
Malik, Asrar
;
Zeng, Fanli
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2017/12/04
CELL-CYCLE
SCHIZOSACCHAROMYCES-POMBE
FUNCTIONAL HOMOLOGS
INHIBITORY DOMAIN
DNA-REPLICATION
BUDDING YEAST
G1 CYCLIN
PROTEIN
G(1)
SIC1
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect
期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:
Chu, Shifeng
;
Liu, Shaolin
;
Duan, Wenzhen
;
Cheng, Yong
;
Jiang, Xueying
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/27
Chirality
Clausenamide
Dementia
Long-term potentiation
Signaling pathway
Calcium
6-OHDA
6-hydroxyldopamine
ACE
acetylcholinesterase
ACh
acetylcholine
AD
Alzheimer's disease
AUC0–12 h
0–12 h area under curve
APP
amyloid precursor protein
APV
R-2-amino-5-phosphonopentanoate
AUC0−∝
whole area under curve
BBB
blood–brain barrier
BDNF
brain-derived neurotrophic factor
CaM
calmodulin
CaMKII
calmodulin kinase II
ChAT
choline acetyltransferase
CREB
cAMP responding element binding
CHM
Chinese herbal medicine
clau
clausenamide
CL
clearance
Cmax
maximum concentration
CDK-5
cyclin-dependent kinase-5
DM
diabetes mellitus
DAG
diacylglycerol
ER
endoplasmic reticulum
ERK
extracellular signal-regulated kinases
GSK-3
glycogen synthase kinase-3
IP3
inositol triphosphate
LTP
long term potentiation
MWM
Morris water maze
NGF
nerve growth factor
NMDA
N-Methyl-D-aspartate
D
nNOS
neural nitric oxide synthase
PAT
passive avoidance tasks
Pir
piracetam
PLC
phospholipase C
PP1
phosphate 1
PKC
protein kinase C
tmax
time of peak concentration
t1/2α
absorption half-life
t1/2β
elimination half-life
Tau
microtubule-associated proteins
TCM
traditional Chinese medicine
Vd
apparent volume of distribution
VDCC
voltage-dependent calcium channel
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y
期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:
Ma, Yun*
;
Tian, Shuai
;
He, Shuya*
;
Chen, Qiong
;
Wang, Zongbao
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/27
mRNA
messenger ribonucleic acid
miRNA
micro ribonucleic acid
TNF-α
tumor necrosis factor-alpha
SH-SY5Y
cells SH-SY5Y neuroblastoma cells
Ago2
Argonaute 2
USP32
ubiquitin specific peptidase 32
RAB18
member RAS oncogene family
Dusp6
dual specificity phosphatase 6
Cdkn1a
cyclin-dependent kinase inhibitor 1A
Bcl-2
B-cell lymphoma-2
FMRP
fragile X mental retardation protein
FXR1P
fragile X-related 1 protein
FXR2P
fragile X-related 2 protein
3′UTR
3′untranslated regions
CDS
coding sequence
FACS
fluorescence activated cell sorter
PMSF
phenylmethanesulfonyl fluoride
SDS-PAGE
sodium dodecyl sulfate-polyacrylamide gel electrophoresis
ANOVA
analysis of variance
SD
standard deviation
PCR
polymerase chain reaction
miR-19b
FXR1
RAB18
USP32
Dusp6
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y
期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:
Ma, Yun*
;
Tian, Shuai
;
He, Shuya*
;
Chen, Qiong
;
Wang, Zongbao
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/27
mRNA
messenger ribonucleic acid
miRNA
micro ribonucleic acid
TNF-α
tumor necrosis factor-alpha
SH-SY5Y
cells SH-SY5Y neuroblastoma cells
Ago2
Argonaute 2
USP32
ubiquitin specific peptidase 32
RAB18
member RAS oncogene family
Dusp6
dual specificity phosphatase 6
Cdkn1a
cyclin-dependent kinase inhibitor 1A
Bcl-2
B-cell lymphoma-2
FMRP
fragile X mental retardation protein
FXR1P
fragile X-related 1 protein
FXR2P
fragile X-related 2 protein
3′UTR
3′untranslated regions
CDS
coding sequence
FACS
fluorescence activated cell sorter
PMSF
phenylmethanesulfonyl fluoride
SDS-PAGE
sodium dodecyl sulfate-polyacrylamide gel electrophoresis
ANOVA
analysis of variance
SD
standard deviation
PCR
polymerase chain reaction
miR-19b
FXR1
RAB18
USP32
Dusp6
Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells
期刊论文
Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, 卷号: 23, 期号: 13, 页码: 1555-1565
作者:
Chen, Xin
;
Wu, Qiu-Shuang
;
Meng, Fan-Cheng
;
Tang, Zheng-Hai
;
Chen, Xiuping
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/27
Panacis Japonici Rhizoma
Chikusetsusaponin IVa methyl ester
Ovarian cancer
Cell cycle arrest
Apoptosis
Metastasis
Bcl-2
B-cell lymphoma 2
CC
column chromatography
CDK
cyclin-dependent kinase
DMEM
Dulbecco's modified Eagle's medium
DMSO
dimethyl sulfoxide
FBS
fetal bovine serum
GAPDH
Glyceraldehyde 3-phosphate dehydrogenase
Hoechst 33342
2′-[4-ethoxyphenyl]-5-[4-methyl-1-piperazinyl]-2,5′-bi-1H-benzimidazole trihydrochloride trihydrate
JC-1
5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimi-dazolylcarbocyanine iodide
MMP
matrix metalloproteinase
MTT
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide
PARP
Poly (ADP-ribose) polymerase
PBS
phosphate-buffered saline
PI
ropidium iodide
PJR
Panacis Japonici Rhizoma
SD
standard deviation
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