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北京大学 [11]
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Identification of 8-miRNAs as biomarkers for nonalcoholic fatty liver disease
期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 卷号: 234, 期号: 10
作者:
Yu, Yuanjie
;
Zhu, Jie
;
Liu, Juan
;
Huang, Mengjun
;
Wan, Jin-Xiang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
function
microRNAs
NAFLD
systematically analysis
食用蔬菜能吸收和积累微塑料
期刊论文
科学通报, 2019, 卷号: 64, 期号: 9, 页码: 928-934
作者:
李连祯
;
周倩
;
尹娜
;
涂晨
;
骆永明
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2020/06/17
微塑料
生菜
聚苯乙烯微球
吸收
积累
健康风险
microplastics
lettuce
polystyrene microbeads
uptake
accumulation
human health risk
Microplastic (MP, 100 nm-5 mm) may present an attributable risk to ecosystem and human health, and its pollution has become a global environmental concern. Despite a wealth of information on the accumulation of MPs in aquatic species, there is no information on the uptake and accumulation of MPs by higher plants. Terrestrial edible plants are directly exposed to MPs when agricultural soil was applied with organic manure, sewage sludge as fertilizer or plastic mulching. In this paper, the uptake of two sizes of polystyrene (PS) microbeads (0.2 and 1.0 mum) and then their distribution and migration in an edible plant lettuce were firstly investigated based on laboratory experiments. We used fluorescent markers to track PS microbeads in plant tissues and found fluorescence to be a sensitive and reliable detection method. Sections from untreated control lettuce showed no autofluorescence. When roots were treated with fluorescently labeled PS microbeads, the microbeads could be identified by its fluorescence. Our main study investigated the uptake of 0.2 mum beads, as few luminescence signals were observed in lettuce roots for 1.0 mum beads in our experiment. We observed that 0.2 mum fluorescent microbeads were extracellularly trapped in the root cap mucilage (which is a highly hydrated polysaccharide) and a dark green tip (which was typical of lettuce roots exposed to label PS beads) was usually visible to the naked eye. Confocal images revealed that the PS luminescence signals were mainly located in the vascular system and on the cell walls of the cortex tissue of the roots, indicated that the beads passed through the intercellular space via the apoplastic transport system. Once inside the central cylinder, the 0.2 mum PS beads were transferred from the roots to the stems and leaves via the vascular system following the transpiration stream. We also observed that the PS beads adhered to one another and self-assembled systematically into grape-like and (chain) string-like clusters in the intercellular space of the root and stem vascular tissue of lettuce plant. In contrast to the root and stem, PS beads were dispersed in the leaf tissue. Here, for the first time we provide evidence of the adherence, uptake, accumulation, and translocation of submicrometer MPs within an edible plant. Our findings highlight the previously underappreciated human exposure pathway to MPs through the consumption of contaminated crops and emphasize the need for new management strategies to control the release of MPs waste products into the terrestrial environment. Ultimately, the potential impacts of low range sized MPs on food safety of crop plants and human health need to be urgently considered.
Bioorthogonal chemistry in living animals
期刊论文
NATIONAL SCIENCE REVIEW, 2017
Fan, Xinyuan
;
Li, Jie
;
Chen, Peng R.
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2017/12/03
ligation
interfering
triggered
satisfying
handle
kinetics
powerful
systematically
faster
intro
RELEASE
CELLS
CLICK
DRUG
MICE
Correlations between neutrons and protons near the Fermi surface and Q(alpha) of superheavy nuclei
期刊论文
PHYSICAL REVIEW C, 2016, 卷号: 93, 期号: 1, 页码: 14302
作者:
Wang, N
;
Liu, M
;
Wu, XZ
;
Meng, J
;
Wang, N (reprint author), Guangxi Normal Univ, Dept Phys, Guilin 541004, Peoples R China.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2017/10/13
The Shell Corrections And Shell Gaps In Nuclei Are Systematically Studied With The Latest Weizsacker-skyrme
(Ws4) Mass Model. We Find That Most Of Asymmetric Nuclei With (Sub) Shell Closures Locate Along The Shell Stability
Line (Ssl)
n=1.37z+13.5
Which Might Be Due To a Strong Correlation Between Neutrons And proTons Near
The Fermi Surface. The Double Magicity Of Nuclei Si-46 And Ni-78 Is Predicted According To The Corresponding
Shell Gaps
Shell Corrections
And Nuclear Deformations. The Unmeasured Superheavy Nuclei
(296)118 And (298)120
With Relatively Large Shell Gaps And Shell Corrections
Also Locate Along The Ssl
Whereas The Traditional Magic
Nucleus (298)F1 Evidently Deviates From The Line. The Alpha-decay Energies Of Superheavy Nuclei With Z=113-126
Are Simultaneously Investigated By Using The Ws4 Model togeTher With The Radial Basis Function Corrections. For
Superheavy Nuclei With Large Shell Corrections
The Smallest Alpha-decay Energy For Elements Z=116
117
And 118
In Their Isotope chaIns LocAtes At N=178 rAther Than 184.
Correlations between neutrons and protons near the Fermi surface and Q(alpha) of superheavy nuclei
期刊论文
PHYSICAL REVIEW C, 2016, 卷号: 93, 期号: 1, 页码: 14302
作者:
Wang, N
;
Liu, M
;
Wu, XZ
;
Meng, J
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/04/08
The shell corrections and shell gaps in nuclei are systematically studied with the latest Weizsacker-Skyrme
HEAVIEST NUCLEI
(WS4) mass model. We find that most of asymmetric nuclei with (sub) shell closures locate along the shell stability
MASSES
line (SSL)
DEFORMATIONS
N=1.37Z+13.5
which might be due to a strong correlation between neutrons and protons near
the Fermi surface. The double magicity of nuclei Si-46 and Ni-78 is predicted according to the corresponding
shell gaps
shell corrections
and nuclear deformations. The unmeasured superheavy nuclei
(296)118 and (298)120
with relatively large shell gaps and shell corrections
also locate along the SSL
whereas the traditional magic
nucleus (298)F1 evidently deviates from the line. The alpha-decay energies of superheavy nuclei with Z=113-126
are simultaneously investigated by using the WS4 model together with the radial basis function corrections. For
superheavy nuclei with large shell corrections
the smallest alpha-decay energy for elements Z=116
117
and 118
in their isotope chains locates at N=178 rather than 184.
Fine Tuning of Crystal Packing and Charge Transport Properties of BDOPV Derivatives through Fluorine Substitution
其他
2016-01-01
Jin-Hu Dou
;
Jie-Yu Wang
;
Jian Pei
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2017/12/03
reorganization
packing
absolute
stacking
tuning
systematically
simply
substituent
backbone
desired
reorganization
packing
absolute
stacking
tuning
systematically
simply
substituent
backbone
desired
Magnetic properties and magnetic exchange interactions in GdRE(RE=Pr,Nd) alloys
期刊论文
稀土学报(英文版), 2016, 卷号: 第5期, 页码: 489-494
作者:
肖素芬
;
陈云贵
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/03/28
systematically
crystalline
magnetization
Curie
magnetometer
RE=Pr,Nd
alloys
x)RE_x
hexagonal
saturation
High performance photodetectors based on high quality InP nanowires
期刊论文
Chinese Physics B, 2016, 卷号: 第11期, 页码: 604-610
作者:
Yang YK(杨燕琨)
;
Yang TF(杨铁锋)
;
Li HL(李洪来)
;
Qi CY(祁朝阳)
;
Chen XL(陈新亮)
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/31
systematically crystallinity photodetector explain simply junction brilliant illumination tunneling attractive
Natural product as a driving force for discovery in organic synthesis and chemical biology
其他
2015-01-01
Lei
;
Xiaoguang
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2017/12/03
systematically
landscape
bioactive
tremendous
biomedical
driving
structurally
subsequent
probes
elucidate
Mechanistic studies of transcriptional regulation by non-CpG methylated DNA
其他
2015-01-01
Jianshi Jin
;
Tengfei Lian
;
Chan Gu
;
Kai Yu
;
Yi Qin Gao
;
Xiao-Dong Su
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2017/12/03
methylation
DNA
genomic
epigenetic
systematically
distinguish
interact
validated
affecting
regulating
methylation
DNA
genomic
epigenetic
systematically
distinguish
interact
validated
affecting
regulating
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