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科研机构
复旦大学上海医学院 [22]
南华大学 [2]
清华大学 [2]
北京大学 [2]
化学研究所 [2]
大连化学物理研究所 [2]
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期刊论文 [42]
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2019 [3]
2018 [2]
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2016 [5]
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Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1
期刊论文
EXPERIMENTAL NEUROLOGY, 2019, 卷号: 311
作者:
Lu, Mei-Hong
;
Ji, Wen-Li
;
Xu, De-En
;
Yao, Pei-Pei
;
Zhao, Xiu-Yun
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/04
BACE1
Sphingomyelin
Amyloid-beta
Lysosomal degradation
Alzheimer's disease
Lipids
Design and Synthesis of the Diazirine-based Clickable Photo-Affinity Probe Targeting Sphingomyelin Synthase 2
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 6
作者:
Wang, Penghui
;
Li, Zhining
;
Jiang, Lulu
;
Zhou, Lu
;
Ye, Deyong
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
Sphingomyelin synthase 2
sphingomyelin
photo-affinity labeling
diazirine
phosphatidylcholine
phosphoethanolamine
Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 163
作者:
Li, Yali
;
Huang, Taomin
;
Lou, Bin
;
Ye, Deyong
;
Qi, Xiangyu
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/12/05
Sphingomyelin synthase 2
Inhibitor
ApoE KO mice
Atherosclerosis
Ordering effects of cholesterol on sphingomyelin monolayers investigated by high-resolution broadband sum-frequency generation vibrational spectroscopy
期刊论文
CHINESE CHEMICAL LETTERS, 2018, 卷号: 29, 期号: 3, 页码: 357-360
作者:
Li, Yiyi
;
Feng, Rongjuan
;
Lin, Lu
;
Liu, Minghua
;
Guo, Yuan
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/04/09
Sphingomyelin
Cholesterol
Ordering Effect
Air/liquid Interface
High-resolution Broadband Sum Frequency Generation
Vibrational Spectroscopy
2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 47
作者:
Lou, Bin
;
Liu, Qi
;
Hou, Jiahui
;
Kabir, Inamul
;
Liu, Peipei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/05
sphingolipid
phospholipid
lipid
lipid metabolism
cancer
2-hydroxy-oleic acid (2OHOA)
anti-cancer drug
lysophosphatidylcholine acyltransferase (LPCAT)
sphingomyelin synthase (SMS)
sphingomyelin
phosphatidylcholine
Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 15
作者:
Qi, Xiang-Yu
;
Cao, Yang
;
Li, Ya-Li
;
Mo, Ming-Guang
;
Zhou, Lu
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Sphingomyelin synthase 2
Anti-atherosclerosis
Oxazolopyridine
Selective inhibitor
SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells
期刊论文
CELL BIOLOGY AND TOXICOLOGY, 2016, 卷号: 32, 期号: 6
作者:
Jin, Guiying
;
Li, Yang
;
Zhu, Yuwen
;
Du, Lisha
;
Yan, Junkai
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
Sphingomyelin synthase
P-glycoprotein
Multidrug resistance protein 2
Pregnane X receptor
Phosphorylated signal pathways
Association of the MTHFR rs1801131 and rs1801133 variants in sporadic Parkinson's disease patients
期刊论文
Neuroscience Letters, 2016, 卷号: 616, 页码: 26-31
作者:
Yuan, Lamei
;
Song, Zhi
;
Deng, Xiong
;
Xiong, Wei
;
Yang, Zhijian
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/03
PD
Parkinson’s disease
MAPT
the microtubule-associated protein tau gene
GBA
the glucocerebrosidase gene
SMPD1
the sphingomyelin phosphodiesterase 1, acid lysosomal gene
MTHFR
the methylenetetrahydrofolate reductase gene
dbSNP
database of single nucleotide polymorphisms
SIFT
Sorting Intolerant from Tolerant
PolyPhen-2
Polymorphism Phenotyping version 2
MALDI-TOF MS
Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
PCR
polymerase chain reaction
PASW
Predictive Analytics Software
OR
odds ratio
CI
confidence interval
Parkinson’s disease
MTHFR gene
Variant
rs1801131
rs1801133
Levels of Blood Organophosphorus Flame Retardants and Association with Changes in Human Sphingolipid Homeostasis
期刊论文
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2016
Zhao, Fanrong
;
Wan, Yi
;
Zhao, Haoqi
;
Hu, Wenxin
;
Mu, Di
;
Webster, Thomas F.
;
Hu, Jianying
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2017/12/04
HOUSE-DUST CONCENTRATIONS
TANDEM MASS-SPECTROMETRY
TRIPHENYL PHOSPHATE
INDOOR ENVIRONMENTS
DIPHENYL PHOSPHATE
PLASMA
PLASTICIZERS
SPHINGOMYELIN
METABOLITES
ATHEROSCLEROSIS
Riccardin D-N induces lysosomal membrane permeabilization by inhibiting acid sphingomyelinase and interfering with sphingomyelin metabolism in vivo
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2016, 卷号: 310, 页码: 175-184
作者:
Li, Lin
;
Niu, Huanmin
;
Sun, Bin
;
Xiao, Yanan
;
Li, Wei
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/16
Lysosome
Cathepsin
Acid sphingomyelinase
Sphingomyelin
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