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Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Wei, Yuan-yuan
;
Ma, Yan
;
Yao, Song-yu
;
Kong, Ling-hui
;
Liu, Xiao
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/11/04
kappa-opioid receptor agonist
4,5-expoxymorphinan
antinociception
conditioned place aversion
sedation
U50,488H
morphine
Nor-BNI
beta-FNA
Amygdala dynorphin/kappa opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zan, Gui-ying
;
Sun, Xiang
;
Wang, Yu-jun
;
Liu, Rui
;
Wang, Chen-yao
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/08/17
depression
social defeat stress
amygdala
κ
opioid receptor
dynorphin
c-fos
ERK
norBNI
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:
Liu, Xiao
;
Jiang, Shuang
;
Kong, Linghui
;
Ye, Rongrong
;
Xiao, Li
收藏
  |  
浏览/下载:116/0
  |  
提交时间:2021/05/24
Morphinans
arylacetamidyl substituent
kappa opioid receptor modulators
structure-activity relationships
Homology modeling and 3D-QSAR study of benzhydrylpiperazine delta opioid receptor agonists
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 83, 页码: 9
作者:
Pan, Chenling
;
Meng, Hao
;
Zhang, Shuqun
;
Zuo, Zhili
;
Shen, Yuehai
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/03/18
delta opioid receptor agonists
3D-QSAR
Homology modeling
Molecular dynamics simulation
Molecular docking
Uncovering kappa-opioid receptor agonist-induced PAK1/2 phosphorylation by quantitative phosphoproteomics
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 516, 期号: 1, 页码: 320-326
作者:
Wu, Jianhong
;
Jiang, Qinghui
;
Zhu, Hongwen
;
Zhou, Yanting
;
Lu, Dayun
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
Dimethyl labeling
Kappa-opioid receptor
Kinase-substrate network
p21-activated kinases
Quantitative phosphoproteomics
How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the kappa-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 3, 页码: 1575-1584
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Zhou, Shuangyan
;
Shi, Danfeng
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2019/11/10
kappa-opioid receptor
Gaussian accelerated molecular dynamics simulation
agonist
antagonist
conformational change
A meta-analysis of naldemedine for the treatment of opioid-induced constipation
期刊论文
EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2019, 卷号: 12, 期号: 2
作者:
Song, Xuesong
;
Qu, Xiaoyu
;
Dong, Naifu
;
Teng, Shiyong
;
Wang, Dunwei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
Meta-analysis
naldemedine
opioid-induced constipation
chronic severe pain
mu-receptor antagonist
efficacy
safety
Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens
期刊论文
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2019, 卷号: 15
作者:
Wei, Nai-Li
;
Quan, Zi-Fang
;
Zhao, Tong
;
Yu, Xu-Dong
;
Xie, Qiang
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/12/05
chronic stress
obesity
food addiction
dopamine receptor 2
mu-opioid receptor
nucleus accumbens
Stabilization of mu-opioid receptor facilitates its cellular translocation and signaling
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2019, 卷号: 87, 期号: 10
作者:
Zhu, Cheng
;
Han, Qingjian
;
Samoshkin, Alexander
;
Convertino, Marino
;
Linton, Alexander
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
GPCR
maturation
opioid receptor
protein engineering
signal transduction
-Opioid Receptor Activation Attenuates the Oligomer Formation Induced by Hypoxia and/or -Synuclein Overexpression/Mutation Through Dual Signaling Pathways
期刊论文
MOLECULAR NEUROBIOLOGY, 2019, 卷号: 56, 期号: 5
作者:
Chen, Tao
;
Wang, Qinyu
;
Chao, Dongman
;
Xia, Terry C.
;
Sheng, Shiying
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/05
-Opioid receptor
-Synuclein
DJ-1
CREB
Cytoprotection
Hypoxia
Oligomer formation
TORC1
Parkinson's disease
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