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PEG-Bottlebrush Stabilizer-Based Worm-like Nanocrystal Micelles with Long-Circulating and Controlled Release for Delivery of a BCR-ABL Inhibitor against Chronic Myeloid Leukemia (CML)
期刊论文
PHARMACEUTICS, 2022, 卷号: 14
作者:
Liang, Huamin
;
Zou, Fengming
;
Fu, Liyi
;
Liu, Qingwang
;
Wang, Beilei
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/12/23
drug nanocrystal
stabilizer
micelle
BCR-ABL
chronic myeloid leukemia (CML)
Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
MD2 blockage prevents the migration and invasion of hepatocellular carcinoma cells via inhibition of the EGFR signaling pathway
期刊论文
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2021
作者:
Qi, Yajun
;
Fang, Qilu
;
Li, Qinglin
;
Ding, Haiying
;
Shu, Qi
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/09/06
Hepatocellular carcinoma (HCC)
myeloid differentiation protein 2 (MD2)
epidermal growth factor receptor (EGFR)
migration
invasion
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
Adverse events associated with nilotinib in chronic myeloid leukemia: mechanisms and management strategies
期刊论文
EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2021
作者:
Wang, Zeng
;
Jiang, Liyu
;
Yan, Hao
;
Xu, Zhifei
;
Luo, Peihua
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/04/26
Adverse events
chronic myeloid leukemia
management
mechanisms
molecular target
nilotinib
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7
作者:
Bi, Xiaoyang
;
Chen, Yu
;
Sun, Zhongya
;
Lu, Wenchao
;
Xu, Pan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Drug design
CBP
Bromodomain
Inhibitor
Acute myeloid leukemia
An ultra-long circulating nanoparticle for reviving a highly selective BCR-ABL inhibitor in long-term effective and safe treatment of chronic myeloid leukemia
期刊论文
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020, 卷号: 29
作者:
Fu, Liyi
;
Zou, Fengming
;
Liu, Qingwang
;
Wang, Beilei
;
Wang, Junqing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/11/30
Chronic myeloid leukemia
BCR-ABL
Long-circulating nanoparticle
Drug delivery
Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemia
期刊论文
EXPERIMENTAL CELL RESEARCH, 2020, 卷号: 393
作者:
Chen, Cheng
;
Wang, Li
;
Li, Lili
;
Wang, Aoli
;
Huang, Tao
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/11/26
Acute myeloid leukemia (AML)
Drug response
Gene mutations
Single-cell RNA sequencing of t(8;21) acute myeloid leukemia for risk prediction
期刊论文
ONCOLOGY REPORTS, 2020, 卷号: 43, 期号: 4, 页码: 1278-1288
作者:
Xiong, Qian
;
Huang, Sai
;
Li, Yong-Hui
;
Lv, Na
;
Lv, Chao
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2020/12/10
acute myeloid leukemia
t(8
21)
single-cell RNA-sequencing
prognosis
The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Hao, Bing-bing
;
Li, Xiao-jing
;
Jia, Xing-long
;
Wang, Yu-xing
;
Zhai, Lin-hui
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/07/01
immunomodulatory drugs (IMiDs)
CC-885
BNIP3L
mitophagy
CRBN
acute myeloid leukemia
mitochondria-targeting drugs
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