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Photothermally controlled drug release system with high dose loading for synergistic chemo-photothermal therapy of multidrug resistance cancer
期刊论文
COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 卷号: 175, 期号: 3, 页码: 239-247
作者:
Wu, XX (Wu, Xiaoxia)[ 1,2 ]
;
Liu, J (Liu, Jing)[ 1 ]
;
Yang, LY (Yang, Lingyan)[ 1 ]
;
Wang, F (Wang, Fu)[ 1,3 ]
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2019/03/19
Gold nanoparticles (AuNPs)
High dosage of drug loading
Intelligent control
Synergistic chemo-photothermal therapy
Multidrug resistance (MDR)
Levistolide A synergistically enhances doxorubicin-induced apoptosis of k562/dox cells by decreasing MDR1 expression through the ubiquitin pathway
期刊论文
ONCOLOGY REPORTS, 2019, 卷号: 41, 页码: 1198-1208
作者:
Ding, Yuanyuan
;
Niu, Weibo
;
Zhang, Tao
;
Wang, Jue
;
Cao, Jiao
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/11/19
MDR1
levistolide A
multidrug resistance
chemotherapeutic drugs
downregulation
Tepotinib reverses ABCB1-mediated multidrug resistance in cancer cells
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2019, 卷号: 166
作者:
Wu, Zhuo-Xun
;
Teng, Qiu-Xu
;
Cai, Chao-Yun
;
Wang, Jing-Quan
;
Lei, Zi-Ning
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/05
Tepotinib
Multidrug resistance (MDR)
ATP-binding cassette (ABC) transporter
ABCB1
Tyrosine kinase inhibitor
Levistolide A synergistically enhances doxorubicin-induced apoptosis of k562/dox cells by decreasing MDR1 expression through the ubiquitin pathway
期刊论文
ONCOLOGY REPORTS, 2019, 卷号: 41, 期号: 2, 页码: 1198-1208
作者:
Ding, Yuanyuan
;
Niu, Weibo
;
Zhang, Tao
;
Wang, Jue
;
Cao, Jiao
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
chemotherapeutic drugs
multidrug resistance
levistolide A
downregulation
MDR1
Ribophorin II potentiates P-glycoprotein- and ABCG2-mediated multidrug resistance via activating ERK pathway in gastric cancer.
期刊论文
International journal of biological macromolecules, 2019, 卷号: Vol.128, 页码: 574-582
作者:
Hongzhi Zhang
;
Huijuan Jiang
;
Huixiang Zhang
;
Juncai Liu
;
Xigang Hu
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/17
ABCG2
Gastric
cancer
MDR1
MEK/ERK
pathway
Multidrug
resistance
Ribophorin
II
Galangin (GG) combined with cisplatin (DDP) to suppress human lung cancer by inhibition of STAT3-regulated NF-κB and Bcl-2/Bax signaling pathways
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 97, 页码: 213-224
作者:
Yu, Shuo
;
Gong, Lian-sheng*
;
Li, Nian-feng
;
Pan, Yi-feng
;
Zhang, Lun
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/12/03
MTT
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide
GG
Galangin
DDP
cisplatin
STAT3
signal transducers and activation of transcription
LC
Lung cancer
MDR
multidrug resistance
NSCL
Cnon-small cell lung cancer
Bcl-2
B-cell leukemia/lymphoma 2
Bax
bcl-2-like protein
TRAIL
TNF-related apoptosis-inducing ligand
NF-κB
nuclear factor kappa-light-chain-enhancer of activated B cells
IκBα
inhibitor of NF-κBα
Cyto-c
cytochrome c
Lung cancer
Galangin
Cisplatin
p-STAT3/p65
Bcl-2
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Combinational strategy for high-performance cancer chemotherapy
期刊论文
BIOMATERIALS, 2018, 卷号: 171
作者:
Qin, Si-Yong
;
Cheng, Yin-Jia
;
Lei, Qi
;
Zhang, Ai-Qing
;
Zhang, Xian-Zheng
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Cancer therapy
Combinational mechanism
Multidrug resistance (MDR)
Therapeutic effect
Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one that modulates ABCB1-mediated multidrug resistance
期刊论文
Bioorganic & Medicinal Chemistry, 2018
作者:
Liming Chang
;
Mengwu Xiao
;
Linlin Yang
;
Shuai Wang
;
Sai-Qi Wang
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/26
Multidrug resistance (MDR)
ABC transporters
ABCB1
Triazolo[1,5-a]pyrimidin-7-one
Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR)
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: Vol.26 No.18, 页码: 5006-5017
作者:
Chang, LM
;
Xiao, MW
;
Yang, LL
;
Wang, S
;
Wang, SQ
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/26
Multidrug resistance (MDR)
ABC transporters
ABCB1
Triazolo [1,5-a]pyrimidin-7-one
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