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厦门大学 [2]
水生生物研究所 [2]
上海药物研究所 [1]
中国科学院大学 [1]
华中师范大学 [1]
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期刊论文 [10]
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Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways.
期刊论文
Cancer letters, 2018
作者:
Tang Yan-Lai
;
Sun Xi
;
Huang Li-Bin
;
Liu Xiao-Jian
;
Qin Ge
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/26
Apoptosis
Human
telomerase
reverse
transcriptase
Mixed
lineage
leukemia
P65
Proliferation
Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report
期刊论文
ONCOLOGY LETTERS, 2017, 卷号: 14, 期号: 6
作者:
Wu, Mengyao
;
Li, Xiaoqiu
;
Tang, Feng
;
Zhu, Ping
;
Ding, Tianling
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
mixed-phenotype acute leukemia
T lymphoid/myeloid
extramedullary infiltration
T stem cell leukemia/lymphoma
early T-cell precursor-acute lymphoblastic leukemia
hematopoietic differentiation
lineage commitment
Design and synthesis of benzylpiperidine inhibitors targeting the menin-mll1 interface
期刊论文
Bioorganic & medicinal chemistry letters, 2016, 卷号: 26, 期号: 18, 页码: 4472-4476
作者:
Ren, Jing
;
Xu, Wei
;
Tang, Le
;
Su, Minbo
;
Chen, Danqi
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/05/09
Menin
Mixed lineage leukemia
Mll1
Sar
Inhibitor
Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 18, 页码: 4472-4476
作者:
Ren, Jing
;
Xu, Wei
;
Tang, Le
;
Su, Minbo
;
Chen, Danqi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Menin
Mixed lineage leukemia
MLL1
SAR
Inhibitor
Modeling Human Leukemia Immunotherapy in Humanized Mice
期刊论文
EBIOMEDICINE, 2016, 卷号: 10
作者:
Xia, Jinxing
;
Hu, Zheng
;
Yoshihara, Satoshi
;
Li, Yuying
;
Jin, Chun-Hui
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
Humanized mice
Leukemia
Lymphopenia
Mixed-lineage leukemia fusion gene
Recipient leukocyte infusion
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation
期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:
Liu, Ke
;
Liu, Yanli
;
Lau, Johnathan L
;
Min, Jinrong*
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/23
Histone demethylation
DNA methylation
Inhibitor
Chemical probe
Drug discovery
LSD
lysine-specific histone demethylase
HDAC
histone deacetylase
REST
REST corepressor
DNMT
DNA methyltransferase
MAO
monoamine oxidase
AML
acute myeloid leukemia
KDM
lysine-specific demethylase
MLL
mixed lineage leukemia
FAD
flavin adenine dinucleotide
PCPA
trans-2-phenylcyclopropylamine
2,4-PDCA
2, 4-pyridinedicarboxylic acid
PHD
plant homeobox domain
SCLC
small cell lung cancer
JHDMs
JmjC-domain-containing histone demethylases
NOG
N-oxalylglycine
IOX1
5-carboxy-8-hydroxyquinoline
MDS
myelodysplastic syndrome
2-OG, 2-oxoglutarate or
α-ketoglutarate
G9a
euchromatic histone-lysine N-methyltransferase 2
CoREST complex
restin corepressor complex
SAH
S-adenosyl-l-homocysteine
l
SWI complex
ATP dependent chromatin remodeling complexes
Pan-Histone Demethylase Inhibitor
the inhibitor can simultaneously inhibit both LSDs and JHDMs
LSC colony
leukemic stem cell colony
Pan JmjC domain-containing demethylase inhibitor
the inhibitor can simultaneously inhibit all the members of JHDMs
E2F1
E2F transcription factor 1
E2F2
E2F transcription factor 2
RCC
renal cell carcinoma
ELL Inhibits E2F1 Transcriptional Activity by Enhancing E2F1 Deacetylation via Recruitment of Histone Deacetylase 1
期刊论文
MOLECULAR AND CELLULAR BIOLOGY, 2014, 卷号: 34, 期号: 4, 页码: 765-775
作者:
Zhang, Wei
;
Ji, Wei
;
Liu, Xing
;
Ouyang, Gang
;
Xiao, Wuhan
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2014/08/13
RNA-POLYMERASE-II
ELONGATION-FACTOR ELL
MIXED-LINEAGE LEUKEMIA
DNA-DAMAGE
COMPLEX SEC
CELL-DEATH
MLL-ELL
PROTEIN
GENE
TRANSACTIVATION
MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
期刊论文
http://dx.doi.org/10.1016/j.ccr.2009.12.034, 2010
Thiel, Austin T.
;
Blessington, Peter
;
Zou, Tao
;
Feather, Danielle
;
Wu, Xinjiang
;
Yan, Jizhou
;
Zhang, Hui
;
Liu, Zuguo
;
Ernst, Patricia
;
Koretzky, Gary A.
;
Hua, Xianxin
;
章慧
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2013/12/12
PARTIAL TANDEM DUPLICATION
MIXED-LINEAGE LEUKEMIA
TUMOR-SUPPRESSOR MENIN
ACUTE MYELOID-LEUKEMIA
HISTONE METHYLTRANSFERASE
TRANSCRIPTIONAL ELONGATION
H3K79 METHYLATION
GENE-EXPRESSION
PHD FINGER
STEM-CELLS
MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
期刊论文
http://dx.doi.org/10.1016/j.ccr.2009.12.034, 2010
Thiel, Austin T.
;
Blessington, Peter
;
Zou, Tao
;
Feather, Danielle
;
Wu, Xinjiang
;
Yan, Jizhou
;
Zhang, Hui
;
Liu, Zuguo
;
Ernst, Patricia
;
Koretzky, Gary A.
;
Hua, Xianxin
;
张弘
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2013/12/12
PARTIAL TANDEM DUPLICATION
MIXED-LINEAGE LEUKEMIA
TUMOR-SUPPRESSOR MENIN
ACUTE MYELOID-LEUKEMIA
HISTONE METHYLTRANSFERASE
TRANSCRIPTIONAL ELONGATION
H3K79 METHYLATION
GENE-EXPRESSION
PHD FINGER
STEM-CELLS
Elongation Factor ELL (Eleven-Nineteen Lysine-rich Leukemia) Acts as a Transcription Factor for Direct Thrombospondin-1 Regulation
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 卷号: 284, 期号: 28, 页码: 19142-19152
作者:
Zhou, Jiangang
;
Feng, Xi
;
Ban, Bin
;
Liu, Jingxia
;
Wang, Zhou
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2010/10/13
MIXED LINEAGE LEUKEMIA
ACUTE MYELOID-LEUKEMIA
MLL-ELL
TUMOR-GROWTH
STEM-CELLS
GENE
EXPRESSION
ANGIOGENESIS
P53
POLYMERASE
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