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北京大学 [7]

化学研究所 [5]

上海药物研究所 [4]

山东大学 [2]

长春应用化学研究所 [2]

兰州大学 [1]

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期刊论文 [30]

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浏览/检索结果: 共30条，第1-10条

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	Effect of the cargo lipophilicity on powder micromeritics properties of drug-loaded solid lipid microparticles 期刊论文 JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 卷号: 51 作者: Ma, Cheng; Wang, Wenhao; Huang, Zhengwei; Chen, Xiaona; Ye, Weifen 收藏 \| 浏览/下载：41/0 \| 提交时间：2019/12/05 SLMs Powder micromeritic properties Lipophilicity Interparticle force
	Novel 2-arylthiopropanoyl-CoA inhibitors of alpha-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents 期刊论文 BIOORGANIC CHEMISTRY, 2019, 卷号: 92 作者: Yevglevskis, Maksims; Nathubhai, Amit; Wadda, Katty; Lee, Guat L.; Al-Rawi, Suzanne 收藏 \| 浏览/下载：34/0 \| 提交时间：2019/12/11 alpha-Methylacyl-CoA racemase (AMACR, P504S) Branched-chain fatty acid metabolism Castrate-resistant prostate cancer (CRPC) Drug lipophilicity Enzyme inhibitors Ibuprofen Mixed competitive inhibition Rational drug design Structure-activity relationships
	Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents 期刊论文 Bioorganic Chemistry, 2019, 卷号: 92 作者: Yevglevskis M.; Nathubhai A.; Wadda K.; Lee G.L.; Al-Rawi S. 收藏 \| 浏览/下载：40/0 \| 提交时间：2019/12/11 Branched-chain fatty acid metabolism Castrate-resistant prostate cancer (CRPC) Drug lipophilicity Enzyme inhibitors Ibuprofen Mixed competitive inhibition Rational drug design Structure-activity relationships α-Methylacyl-CoA racemase (AMACR, P504S)
	In silico screening of a novel scaffold for fructose-1,6-bisphosatase (FBPase) inhibitors 期刊论文 Journal of Molecular Graphics and Modelling, 2019, 卷号: 86, 页码: 142-148 作者: Huang, Yunyuan; Chi, Bo; Xu, Yanhong; Song, Rongrong; Wei, Lin 收藏 \| 浏览/下载：33/0 \| 提交时间：2019/12/23 Fructose-1,6-bisphosphate (FBPase) FBPase inhibitors DOX2.0 FBPase fructose-1,6-bisphosphatase FBP fructose-1,6-biphosphate IC50 half maximal inhibitory concentration PAINS Pan Assay Interference T2D Type 2 diabetes SAR structure−activity relationship EGP endogenous glucose production GNG gluconeogenesis AMP adenosine monophosphate DOX Docking ONIOM eXtended ONIOM (XO) DOX2.0 Docking PM7@Mopac XO2 LE ligand efficiency LELP lipophilicity-corrected ligand efficiency
	Simultaneous determination of the lipophilicity and dissociation constants of dialkyl phosphinic acids by negligible depletion hollow fiber membrane-protected liquid-phase microextraction 期刊论文 JOURNAL OF CHROMATOGRAPHY A, 2017, 卷号: 1507, 期号: 0, 页码: 11-17 作者: Shi, Fengqiong; Liu, Jingfu 收藏 \| 浏览/下载：16/0 \| 提交时间：2018/07/26 Dialkyl Phosphinic Acids (Dpas) Lipophilicity (Log d) Dissociation Constant (Pk(a)) Hollow Fiber Uplc-ms/ms
	Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects 期刊论文 CURRENT MEDICINAL CHEMISTRY, 2017, 卷号: 24, 期号: 35, 页码: 3921-3937 作者: Cao, Hua; Wang, Kai; Ye, Yang-Liang; Shen, Jian-Hua 收藏 \| 浏览/下载：18/0 \| 提交时间：2019/01/08 Intestine targeted drugs design strategies lipophilicity aqueous solubility molecular weight soft drugs prodrugs efflux transporters
	Natural Proline-Rich Cyclopolypeptides from Marine Organisms: Chemistry, Synthetic Methodologies and Biological Status 期刊论文 Marine Drugs, 2016, 卷号: 14, 期号: 11, 页码: 194- 作者: Fang, Wan-Yin; Dahiya, Rajiv; Qin, Hua-Li; Mourya, Rita; Maharaj, Sandeep 收藏 \| 浏览/下载：5/0 \| 提交时间：2019/12/04 lipophilicity parameter marine sponge marine tunicate peptide synthesis pharmacological activity proline-rich cyclic peptide *stereochemistry
	Design, synthesis and cytotoxic activities of novel 2,5-diketopiperazine derivatives 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 121, 页码: 500-509 作者: Liao, Sheng-Rong; Qin, Xiao-Chu; Wang, Zhen; Li, Ding; Xu, Liang 收藏 \| 浏览/下载：19/0 \| 提交时间：2016/12/22 2,5-Diketopiperazine derivatives Long alkyl chain Cytotoxic activity Apoptosis Lipophilicity
	Lead compound optimization strategy (5) - reducing the hERG cardiac toxicity in drug development 期刊论文 Acta Pharmaceutica Sinica, 2016, 卷号: 51, 期号: 10, 页码: 1530-1539 作者: Zhou Shengbin; Wang Jiang; Liu Hong 收藏 \| 浏览/下载：46/0 \| 提交时间：2019/01/08 hERG lead compound optimization lipophilicity basicity conformation restriction cardiac toxicity
	In silico evaluation of logD7.4 and comparison with other prediction methods 期刊论文 Journal of Chemometrics, 2015, 卷号: 29, 期号: 7, 页码: 389-398 作者: Wang, Jian-Bing; Cao, Dong-Sheng*; Zhu, Min-Feng; Yun, Yong-Huan; Xiao, Nan 收藏 \| 浏览/下载：7/0 \| 提交时间：2019/12/03 lipophilicity distribution coefficient logD7.4 quantitative structure–property relationship (QSPR) support vector machine (SVM) genetic algorithm (GA)

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