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CORC

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Dihydroartemisinin suppresses the proliferation of Epstein-Barr virus-associated gastric carcinoma cells via downregulation of latent membrane protein 2A 期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 16, 页码: 2613-2619
作者:  Gong, Wei;  Zhang, Lei;  Yu, Hui;  Yu, Qiang;  Pan, Wei-Kang
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/19
Knockdown of LMP1-induced miR-155 sensitizes nasopharyngeal carcinoma cells to radiotherapy in vitro 期刊论文
ONCOLOGY LETTERS, 2016, 卷号: 11, 期号: 5
作者:  Wang, Yusheng;  Sun, Le
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/05
Embelin prevents LMP1-induced TRAIL resistance via inhibition of XIAP in nasopharyngeal carcinoma cells 期刊论文
Oncology letters, 2016, 卷号: 11, 期号: 6, 页码: 4167-4176
作者:  Yang, Shu;  Li, Shi-Sheng*;  Yang, Xin-Ming;  Yin, Dan-Hui;  Wang, Lin
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03
Expression of LMP and EBNA genes in Epstein-Barr virus-associated lymphomas in Hu-PBL/SCID mice 期刊论文
Oncology Reports, 2016, 卷号: 35, 期号: 2, 页码: 905-911
作者:  Tang, Yunlian;  Lu, Suli;  Gan, Xiaoning;  Liu, Fang;  Zhang, Yang
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/27
The copy number of Epstein-Barr virus latent genome correlates with the oncogenicity by the activation level of LMP1 and NF-kappaB. 期刊论文
Oncotarget, 2015, 卷号: 6, 期号: 38, 页码: 41033-41044
作者:  Zuo, Lielian;  Yu, Haibo;  Liu, Lingzhi;  Tang, Yunlian;  Wu, Hongzhuan
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/03
The copy number of Epstein-Barr virus latent genome correlates with the oncogenicity by the activation level of LMP1 and NF-kappaB. 期刊论文
Oncotarget, 2015, 卷号: 6, 期号: 38, 页码: 41033-41044
作者:  Zuo, Lielian;  Yu, Haibo;  Liu, Lingzhi;  Tang, Yunlian;  Wu, Hongzhuan
收藏  |  浏览/下载：5/0  |  提交时间：2019/12/27
Lentivirus-mediated RNAi knockdown of LMP2A inhibits the growth of nasopharyngeal carcinoma cell line C666-1 in vitro 期刊论文
GENE, 2014, 卷号: 542, 期号: 1
作者:  Ying, Xinjiang;  Zhang, Ruxin;  Wang, Hong;  Teng, Yaoshu
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/19
Expression of latent membrane proteins in Epstein-Barr virus-transformed lymphocytes in vitro 期刊论文
Molecular Medicine Reports, 2014, 卷号: 10, 期号: 2, 页码: 1117-1121
作者:  Tang, Yunlian;  Luo, Chunyan;  Cheng, Ailan;  Lu, Suli;  Xu, Jinhua
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/27
Epstein-Barr Virus encoded LMP1 regulates cyclin D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells 期刊论文
Journal of Experimental & Clinical Cancer Research, 2013, 卷号: 32, 期号: 1, 页码: 90
作者:  Xu, Yang;  Shi, Ying;  Yuan, Qi;  Liu, Xuli;  Yan, Bin
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  

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