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厦门大学 [6]
山东大学 [4]
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上海药物研究所 [3]
复旦大学上海医学院 [3]
兰州大学 [2]
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期刊论文 [34]
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Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced in CHO cell fed-batch and perfusion cultures
期刊论文
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 卷号: 103, 期号: 3
作者:
Qin, Jinyan
;
Wu, Xiang
;
Xia, Zhigang
;
Huang, Zheng
;
Zhang, Ying
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
Chinese hamster ovary (CHO)
Hyperosmolality
Fed-batch
Perfusion
Biopotency
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia
期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:
Wu Chenglin
;
Xi Cong
;
Tong Junhua
;
Zhao Jing
;
Jiang Hualiang
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2020/07/01
DOPAMINE D-1
BERBERINE
EXPRESSION
INHIBITORS
IDENTIFICATION
CHOLESTEROL
MUTATIONS
LDLR
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
First case of Stevens-Johnson syndrome after rabies vaccination
期刊论文
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2018, 卷号: 84, 页码: 803-805
作者:
Ma, Li
;
Du, Xusheng
;
Dong, Yu
;
Peng, Lirong
;
Han, Xiaonian
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/11/19
Stevens-Johnson syndrome
rabies vaccination
primary hamster kidney vaccine
Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen
期刊论文
VACCINE, 2018, 卷号: 36, 期号: 14
作者:
Nyon, Mun Peak
;
Du, Lanying
;
Tseng, Chien-Te Kent
;
Seid, Christopher A.
;
Pollet, Jeroen
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Middle East respiratory syndrome coronavirus
Receptor binding domain
Chinese hamster ovary cells
Hypolipidemic activity and mechanisms of the total phenylpropanoid glycosides from Ligustrum robustum (Roxb.) Blume by AMPK-SREBP-1c pathway in hamsters fed a high-fat diet
期刊论文
2018, 卷号: 32, 期号: 4, 页码: 715-722
作者:
Yang, Runmei
;
Chu, Xinxin
;
Sun, Le
;
Kang, Zhuoying
;
Ji, Min
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/01/03
AMP-activated protein kinase (AMPK)
hamster
hyperlipidemia
sterol regulatory element binding protein-1c (SREBP-1c)
total phenylpropanoid glycoside from Ligustrum robustum (Roxb
) Blume (LRTPG)
triglyceride
LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis
期刊论文
2018, 卷号: 27, 页码: 214-224
作者:
Guo, Xin
;
Gao, Mingming
;
Wang, Yunan
;
Lin, Xiao
;
Yang, Liu
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/01/03
LDL receptor
Golden Syrian hamster
Hyperlipidemia
Atherosclerosis
CRISPR/Cas9
Amplification of arsenic genotoxicity by TiO2 nanoparticles in mammalian cells: new insights from physicochemical interactions and mitochondria
期刊论文
NANOTOXICOLOGY, 2017, 卷号: 11, 期号: 8, 页码: 978-995
作者:
Wang, Xinan
;
Liu, Yun
;
Wang, Juan
;
Nie, Yaguang
;
Chen, Shaopeng
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/02/28
TiO2 nanoparticles (TiO2 NPs)
arsenic [As(III)]
human-hamster hybrid (A(L)) cells
synergistic genotoxicity
physicochemical interactions
mitochondria
Expression and bioactivity of recombinant human serum albumin and dTMP fusion proteins in CHO cells
期刊论文
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 卷号: 100, 期号: 17, 页码: 7565-7575
作者:
Ru, Y
;
Zhi, DJ
;
Guo, DD
;
Wang, Y
;
Li, Y
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2017/01/13
Thrombopoietin mimetic peptide
Human serum albumin
Fusion protein
Chinese hamster ovary cells
Complete mitochondrial genome sequence of the heart failure model of cardiomyopathic Syrian hamster (Mesocricetus auratus)
期刊论文
MITOCHONDRIAL DNA PART A, 2016, 卷号: 27, 期号: 3, 页码: 2182-2183
作者:
Hu, Bo
;
Liu, Dong-Xing
;
Zhang, Yu-Qing
;
Song, Jian-Tao
;
Ji, Xian-Fei
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/16
Cardiomyopathic syrian hamster
genome
heart failure
mitochondrion
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