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浏览/检索结果: 共5条，第1-5条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序作者升序作者降序提交时间升序提交时间降序题名升序题名降序 Foreign direct investment and economic growth in Sub-Saharan Africa: The role of institutions 期刊论文 Turkish Economic Review, 2017, 卷号: Vol.4 No.4, 页码: 378-387 作者:  Moga Tano JILENGA;  Xu HELIAN 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/31 FDI  Institutional  quality  GMM  Economic  growth.   Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文 International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118 作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03 DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.   High undercooling of bulk water during acoustic levitation 期刊论文 http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=JGXG200303004&dbname=CJFQ2003, 2012, 2012 吕勇军; 曹崇德; 魏炳波 收藏  |  浏览/下载：2/0  |  提交时间：2017/06/19 acoustic levitation  undercooling  water  crystal growth.   Nucleate Pool Boiling of Pure Liquids and Binary Mixtures: Part I - Analytical Model for Boiling Heat Transfer of Pure Liquids on Smooth Tubes 期刊论文 JOURNAL OF THERMAL SCIENCE, 1995, 卷号: 4, 期号: 2, 页码: 104,111 Guoqing Wang; Zhiwei Xie; Yingke Tan 收藏  |  浏览/下载：9/0  |  提交时间：2013/03/13 nucleate pool boiling  heat transfer  bubble growth.   水分限制条件下小麦碳同化作用和生物量累积的简单机理模型 期刊论文 1994 郑海雷; 黄子琛(中国科学院兰州沙漠研究所); 赵松岭(兰州大学生物系) 收藏  |  浏览/下载：6/0  |  提交时间：2011/04/26 春小麦  生长  水分限制  机理模型  Spring wheat  Growth.  Water limitation  Mechanistic model