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厦门大学 [1]
西北工业大学 [1]
中南大学 [1]
湖南大学 [1]
工程热物理研究所 [1]
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期刊论文 [5]
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2017 [1]
2013 [1]
2012 [1]
1995 [1]
1994 [1]
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Foreign direct investment and economic growth in Sub-Saharan Africa: The role of institutions
期刊论文
Turkish Economic Review, 2017, 卷号: Vol.4 No.4, 页码: 378-387
作者:
Moga Tano JILENGA
;
Xu HELIAN
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/31
FDI
Institutional
quality
GMM
Economic
growth.
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model
期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:
Chen, Yan
;
Yang, Lifang*
;
Huang, Suping
;
Li, Zhi
;
Zhang, Lu
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  |  
浏览/下载:8/0
  |  
提交时间:2019/12/03
DNAzymes are synthetic
single-stranded
catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner
and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application
nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study
we developed an nHAP-based delivery system and explored its cellular uptake mechanisms
intracellular localization
and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors
cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further
effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically
the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model
the complex was shown to be delivered efficiently to tumor tissue
downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.
High undercooling of bulk water during acoustic levitation
期刊论文
http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=JGXG200303004&dbname=CJFQ2003, 2012, 2012
吕勇军
;
曹崇德
;
魏炳波
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  |  
浏览/下载:2/0
  |  
提交时间:2017/06/19
acoustic levitation
undercooling
water
crystal growth.
Nucleate Pool Boiling of Pure Liquids and Binary Mixtures: Part I - Analytical Model for Boiling Heat Transfer of Pure Liquids on Smooth Tubes
期刊论文
JOURNAL OF THERMAL SCIENCE, 1995, 卷号: 4, 期号: 2, 页码: 104,111
Guoqing Wang
;
Zhiwei Xie
;
Yingke Tan
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  |  
浏览/下载:9/0
  |  
提交时间:2013/03/13
nucleate pool boiling
heat transfer
bubble growth.
水分限制条件下小麦碳同化作用和生物量累积的简单机理模型
期刊论文
1994
郑海雷
;
黄子琛(中国科学院兰州沙漠研究所)
;
赵松岭(兰州大学生物系)
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  |  
浏览/下载:6/0
  |  
提交时间:2011/04/26
春小麦
生长
水分限制
机理模型
Spring wheat
Growth.
Water limitation
Mechanistic model
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