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Broad targeting of triptolide to resistance and sensitization for cancer therapy 期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:  Hou, Zhen-yan;  Tong, Xiao-pei;  Peng, Yong-bo;  Zhang, Bi-Kui*;  Yan, Miao*
收藏  |  浏览/下载:50/0  |  提交时间:2019/12/03
ABC  ATP-binding cassette  AKT  V-Akt murine thymoma viral oncogene homolog  ALDH1  aldehyde dehydrogenase 1  AR  androgen receptor  Bad  Bcl-2-associated death promoter  Bak  Bcl-2 homologous antagonist killer  Bax  Bcl-2-associated X protein  Bcl-2  B-cell lymphoma  Bcl-xL  Bcl-extra large  Bcl-xs  Bcl-extra short  BCRP  breast cancer resistance protein  Bid  BH3 interacting domain death agonist  Bik  Bcl-2-interacting killer  BNIP3  Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3  CAF  cancer-associated fibroblast  CAIX  carbonic anhydrase IX  cFLIP  cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein  ChIP  chromatin immunoprecipitation  CI  Combination Index  cIAP1/2  cellular IAP1/2  CML  chronic myelogenous leukemia  CSC  cancer stem cell  DISC  death-inducing signaling complex  DR  death receptor  DRI  Dose Reduction Index  ECM  extracellular matrix  EMT  epithelial-mesenchymal transition  EpCAM  epithelial cell adhesion molecule  GLUT  glucose transporter  GSK3β  glycogen synthase kinase-3β  HIF-1  hypoxia inducible factor-1  HSF1  heat shock factor 1  HSP  heat shock protein  IAP  inhibitor of apoptosis protein  JNK  c-JUN N-terminal kinase  MAPK  mitogen-activated protein kinase  Mcl-1  myeloid leukemia cell differentiation protein  MDM2  murine double minute 2  MDR  multidrug resistance  MKP  MAPK phosphatase  MRP1  multidrug resistance protein 1  NF-κB  nuclear factor-kappaB  pAkt  phosphor-Akt  PARP  poly ADP-ribose polymerase  P-gp  P-glycoprotein  PI3K-PTEN  phosphatidylinositol 3-kinase-phosphatase and tensin homolog  PKC  phosphorylated at Ser9 by protein kinase C  pp2A  protein phosphatase 2A  REST  repressor element-1 silencing transcription factor  SAR  structure-activity relationship  TAM  tumor-associated macrophage  TFIIH  transcription factor IIH  TKI  tyrosine kinase inhibitor  TM  tumor-microenvironment  TRAIL/Apo-2L  TNF-related apoptosis-inducing ligand  tRXRα  the N-terminal truncated form of the nuclear retinoid X receptor-α  TWHF  Tripterygium wilfordii Hook F  VEGF  vascular endothelial growth factor  XIAP  X-linked IAP  XPB  xerodermapigmentosum group B protein  Triptolide  Antineoplastic  Resistance  Sensitization  Mechanism  
Myelin injury in the central nervous system and Alzheimer's disease 期刊论文
Brain Research Bulletin, 2018, 卷号: 140, 页码: 162-168
作者:  Wang, Sha-Sha;  Zhang, Zhao;  Zhu, Tian-Bi;  Chu, Shi-Feng;  He, Wen-Bin
收藏  |  浏览/下载:28/0  |  提交时间:2019/12/27
OLG  oligodendrocyte  CNS  central nervous system  SC  Schwann cell  PNS  peripheral nervous system  MBP  myelin basic protein  PLP  proteolipid protein  P0/MPZ  myelin protein zero  EAE  experimental allergic encephalomyelitis  MS  multiple sclerosis  CNP  2′ 3′-cyclic nucleotide 3′-phosphodiesterase  MAG  myelin associated glycoprotein  MOG  myelin oligodendrocyte glycoprotein  AD  Alzheimer's disease  OPC  oligodendrocyte precursor cell  NPC  neural progenitor cell  ROS  reactive oxygen species  TNF  tumour necrosis factor  AIF  apoptosis-inducing factor  IFN-γ  interferon gamma  ERK1/2  extracellular signal-regulated kinases-1 and -2  MAPK  mediators of mitogen-activated protein kinase  FGFR1/2  fibroblast growth factor receptors-1 and -2  Dock3  dedicator of cytokinesis 3  PERK  pancreatic endoplasmic reticulum kinase  GEF  guanine nucleotide exchange factor  SIRT2  sirtuin 2  NOD2  Nucleotide-binding oligomerization domain containing protein 2  RIPK2  receptor-interacting serine/threonine kinase 2  Shh  Sonic Hedgehog  NMO  neuromyelitis optica  ADEM  acute disseminated encephalomyelitis  ANHLE  acute necrotizing hemorrhagic leukoencephalitis  CPM  central pontine myelinolysis    beta-amyloid  SP  senile plaque  NFT  neurofibrillary tangle  MRI  magnetic resonance imaging  Myelin  Oligodendrocyte  Demyelination  Neurodegenerative diseases  Alzheimer’s disease  
The non-small cell lung cancer EGFR extracellular domain mutation, M277E, is oncogenic and drug-sensitive 期刊论文
ONCOTARGETS AND THERAPY, 2017, 卷号: 10
作者:  Yu, Su;  Zhang, Yang;  Pan, Yunjian;  Cheng, Chao;  Sun, Yihua
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/05
Structure modification and extracellular polymeric substances conversion during sewage sludge biodrying process SCI/SSCI论文
2016
作者:  Cai L.;  Krafft, T.;  Chen, T. B.;  Gao, D.;  Wang, L.
收藏  |  浏览/下载:25/0  |  提交时间:2017/11/09
Structure modification and extracellular polymeric substances conversion during sewage sludge biodrying process SCI/SSCI论文
2016
作者:  Cai L.;  Krafft, T.;  Chen, T. B.;  Gao, D.;  Wang, L.
收藏  |  浏览/下载:34/0  |  提交时间:2016/12/16
Epigenetic dynamics in immunity and autoimmunity 期刊论文
The International Journal of Biochemistry & Cell Biology, 2015, 卷号: 67, 页码: 65-74
作者:  Zhao, Ming;  Wang, Zijun;  Yung, Susan;  Lu, Qianjin*
收藏  |  浏览/下载:20/0  |  提交时间:2019/12/03
Epigenetic dynamics  Immune system  Autoimmune diseases  DNA methylation  Histone modifications  DNMT  DNA methyltransferase  TET  ten-eleven translocation  AID/AICDA  activation-induced cytidine deaminase  APOBEC  Apolipoprotein B mRNA editing enzyme  BER  base excision repair  MBD4  methyl-CpG binding domain protein 4  HATs  histone acetyltransferases  HDAC  histone deacetylase  HMT  histone methyltransferase  5mC  5-methylcytosine  5hmC  5-hydroxymethylcytosine  GC  germinal center  DC  dendritic cell  SHM  somatic hypermutation  CSR  class switch recombination  Blimp-1  B lymphocyte-induced maturation protein-1  Treg  regulatory T  NFAT  nuclear factor of activated T-cells  TSDR  Treg-specific demethylated region  PDCD1  programmed cell death 1  Prf1  Perforin  Gzmb  Granzyme B  CTL  cytotoxic T cell  EBF1  early B cell factor1  Pax5  Paired box protein  TSA  Trichostatin A  SLE  systemic lupus erythematosus  RA  rheumatoid arthritis  MS  multiple sclerosis  T1D  type 1 diabetes mellitus  ERK  extracellular regulated protein kinases  PBMC  peripheral blood mononuclear cell  PAD2  peptidylarginine deiminase 2  IGFBP-1  insulin-like growth factor-binding protein 1  LPS  lipopolysaccharide  
Peptide signalling during the pollen tube journey and double fertilization 期刊论文
JOURNAL OF EXPERIMENTAL BOTANY, 2015
Qu, Li-Jia; Li, Ling; Lan, Zijun; Dresselhaus, Thomas
收藏  |  浏览/下载:103/0  |  提交时间:2017/12/03
Functional expression of the Fc-fused extracellular domains of group II membrane proteins 期刊论文
GLYCOCONJUGATE JOURNAL, 2015, 卷号: 32, 期号: 1-2
作者:  Wu, Weicheng;  Jin, Jing;  Liu, Xiaojuan;  Zhang, Yufei;  Li, Meng
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/19
Interferon-γ in foam cell formation and progression of atherosclerosis 期刊论文
Clinica Chimica Acta, 2015, 卷号: 441, 页码: 33-43
作者:  Xiao-HuaYu;  JianZhang;  Xi-LongZheng;  Yun-HuaYang;  Chao-KeTang
收藏  |  浏览/下载:8/0  |  提交时间:2019/12/27
IFN-γ  interferon-γ  IFNGR  IFN-γ receptor  VSMC  vascular smooth muscle cell  IL  interleukin  LPS  lipopolysaccharide  TNF-α  tumor necrosis factor-α  STAT  signal transducer and activator of transcription  NF-κB  nuclear factor-κB  TLR  Toll-like receptor  Tyr  tyrosine  Ser  serine  PI3Ks  phosphatidyl inositol-3 kinases  miRNAs  microRNAs  TGF-β  transforming growth factor-β  Blimp-1  B lymphocyte-induced maturation protein-1  Bcl-6  B cell lymphoma-6  NOD2  nucleotide-binding oligomerization domain 2  JAK  Janus kinase  GAS  IFN-γ activation sequences  ERK  extracellular signal-regulated kinase  PKC  protein kinase C  SOCS  suppressor of cytokine signaling  IP-10  inducible protein-10  ox-LDL  oxidized low-density lipoprotein  SRs  scavenger receptors  ACAT1  Acyl coenzyme A:cholesterol acyltransferase 1  ABCA1  ATP-binding cassette transporter A1  apo E  apolipoprotein E  MMP  matrix metalloproteinase  IFN-γ  Foam cells  Atherosclerosis  Myocardial infarction  Stroke  
MicroRNAs: New players in intervertebral disc degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 450, 页码: 333-341
作者:  Wang, Cheng;  Wang, Wen-Jun;  Yan, Yi-Guo;  Xiang, Yong-Xiao;  Zhang, Jian
收藏  |  浏览/下载:22/0  |  提交时间:2019/12/27
IVD  intervertebral disc  NP  nucleus pulposus  AF  annulus fibrosus  CEPs  cartilaginous endplates  IDD  intervertebral disc degeneration  ECM  extracellular matrix  miRNAs  microRNAs  RNA pol  RNA polymerase  DGCR8  DiGeorge syndrome critical gene 8  Exp 5  exportin 5  TRBP  transactivating response RNA-binding protein  RISC  RNA-induced silencing complex  Ago  Argonaute  PI3K  phosphoinositide 3-kinase  MAPK  mitogen-activated protein kinase  TGF-β  transforming growth factor-β  PDGF  platelet-derived growth factor  IGF  insulin-like growth factor  EGF  epidermal growth factor  CDKI1B  cyclin-dependent kinase inhibitor 1B  TNF-α  tumor necrosis factor-α  FADD  Fas-associated death domain-containing protein  Col II  type II collagen  Col I  type I collagen  MMPs  matrix metalloproteinases  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  Col I  type I collagen  Col II  type II collagen  FGF2  fibroblast growth factor 2  FGFR  fibroblast growth factor receptor  IL-1β  interleukin-1β  NGF  nerve growth factor  HOXD10  homeobox D10  MiRNAs  IDD  NP cells  Apoptosis  Cell proliferation  


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