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环境与生物因素对碳纳米材料 毒性 效应的影响机制 学位论文
北京: 中国科学院生态环境研究中心, 2018
作者:  吴亚坤
收藏  |  浏览/下载：18/0  |  提交时间：2020/07/28
Cancer Treatment with Liposomes Based Drugs and Genes Co-delivery Systems. 期刊论文
Current medicinal chemistry, 2018, 卷号: 25, 页码: 3319-3332
作者:  Zhang Chuanmin;  Zhang Shubiao;  Zhi Defu;  Cui Jingnan
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/02
Natural Product Gossypol and Its Derivatives in Precision Cancer Medicine. 期刊论文
Current medicinal chemistry, 2017
作者:  Zeng Yun;  Ma Jingwen;  Xu Liang;  Wu Daocheng
收藏  |  浏览/下载：3/0  |  提交时间：2019/11/26
Institutional quality and economic growth in East African economies 期刊论文
Turkish Economic Review, 2017, 卷号: Vol.4 No.3, 页码: 282-289
作者:  Moga Tano JILENGA;  Xu HELIAN
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/31
Genetic analysis of body weight of Takifugu rubripes at different developmental stages 期刊论文
African Journal of Biotechnology, 2016, 期号: 45, 页码: 2558-2564
作者:  Aijun Ma[1];  Xin’an Wang[2]
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/02
Bioactive Coumarins from the Stems of Clausena emarginata 期刊论文
2016, 卷号: 13, 期号: 9, 页码: 1178-1185
作者:  Ouyang, Guo-Qing;  Li, Chuang-Jun
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/04
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  
康熙瓷胎画珐琅款式与“年款的激励效应” 期刊论文
2010, 2010
周思中; ZHOU Sizhou
收藏  |  浏览/下载：1/0
Athermalization of coaxial reflective space telescope (EI CONFERENCE) 会议论文
5th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Large Mirrors and Telescopes, April 26, 2010 - April 29, 2010, Dalian, China
Lei Z.; Guang J.
收藏  |  浏览/下载：14/0  |  提交时间：2013/03/25
Non-uniformity correction in multi-CCD imaging system (EI CONFERENCE) 会议论文
2010 2nd International Conference on Mechanical and Electronics Engineering, ICMEE 2010, August 1, 2010 - August 3, 2010, Kyoto, Japan
Tao M.; Ren J.
收藏  |  浏览/下载：16/0  |  提交时间：2013/03/25
The non-uniformity phenomenon exists in each channel of multi-CCD imaging systems. The factors which lead to the problem are complex. The conventional calibrating algorithms can not consider all of these factors and have poor effects. According to the characters of multi-CCD imaging systems  a non-uniformity correction method based on the scene was proposed by adopting the traditional two-point correction theories. The correction coefficient of each channel image can be calculated via the linear relation between the two neighboring pixel lines in the two-channel images. Compared with the conventional two-point calibration and multi-point calibration methods  contrastive calibrating results were obtained. This method does not need any standard lighted image as reference source  which provides a real time way for calibrating the multi-CCD imaging systems in practical applications. 2010 IEEE.  

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