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环境与生物因素对碳纳米材料 毒性 效应的影响机制
学位论文
北京: 中国科学院生态环境研究中心, 2018
作者:
吴亚坤
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/28
碳纳米材料, 肺 脏 肝脏,巨噬细胞,毒性效应
Carbon Nanomaterials, Lung, Liver, Macrophages, Toxic Effects.
Cancer Treatment with Liposomes Based Drugs and Genes Co-delivery Systems.
期刊论文
Current medicinal chemistry, 2018, 卷号: 25, 页码: 3319-3332
作者:
Zhang Chuanmin
;
Zhang Shubiao
;
Zhi Defu
;
Cui Jingnan
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/02
cancer therapy,co-delivery,drug,gene,liposomes,synergistic effects.
Natural Product Gossypol and Its Derivatives in Precision Cancer Medicine.
期刊论文
Current medicinal chemistry, 2017
作者:
Zeng Yun
;
Ma Jingwen
;
Xu Liang
;
Wu Daocheng
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  |  
浏览/下载:3/0
  |  
提交时间:2019/11/26
Gossypol
Apoptosis
Autophagy
Anti-tumor effects
Nanocarriers
Bcl-2 family proteins
Synergistic effects.
Institutional quality and economic growth in East African economies
期刊论文
Turkish Economic Review, 2017, 卷号: Vol.4 No.3, 页码: 282-289
作者:
Moga Tano JILENGA
;
Xu HELIAN
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/31
Institutional
quality
Economic
growth
East
Africa
Fixed
effects.
Genetic analysis of body weight of Takifugu rubripes at different developmental stages
期刊论文
African Journal of Biotechnology, 2016, 期号: 45, 页码: 2558-2564
作者:
Aijun Ma[1]
;
Xin’an Wang[2]
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  |  
浏览/下载:2/0
  |  
提交时间:2020/01/02
Takifugu rubripes
body weight
genetic parameters
gene effects.
Bioactive Coumarins from the Stems of Clausena emarginata
期刊论文
2016, 卷号: 13, 期号: 9, 页码: 1178-1185
作者:
Ouyang, Guo-Qing
;
Li, Chuang-Jun
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  |  
浏览/下载:2/0
  |  
提交时间:2020/01/04
Clausena emarginata
Stems
Clauemarmarins
Neuroprotective effects
Inhibitory effects.
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model
期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:
Chen, Yan
;
Yang, Lifang*
;
Huang, Suping
;
Li, Zhi
;
Zhang, Lu
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  |  
浏览/下载:8/0
  |  
提交时间:2019/12/03
DNAzymes are synthetic
single-stranded
catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner
and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application
nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study
we developed an nHAP-based delivery system and explored its cellular uptake mechanisms
intracellular localization
and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors
cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further
effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically
the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model
the complex was shown to be delivered efficiently to tumor tissue
downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.
康熙瓷胎画珐琅款式与“年款的激励效应”
期刊论文
2010, 2010
周思中
;
ZHOU Sizhou
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  |  
浏览/下载:1/0
Athermalization of coaxial reflective space telescope (EI CONFERENCE)
会议论文
5th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Large Mirrors and Telescopes, April 26, 2010 - April 29, 2010, Dalian, China
Lei Z.
;
Guang J.
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浏览/下载:14/0
  |  
提交时间:2013/03/25
This paper focuses on thermal effects
which caused by environmental temperature changes
on coaxial reflective space telescope and its solution. Curvature radius and center thickness of optical elements
and the space distance between optical elements may be changed by thermal effects. And the optical performance of the telescope may be impacted. Based on the analysis of thermal effects on coaxial reflective space telescope
athermalized design techniques are emphatically presented
the advantages and the disadvantages of the three athermalizations used currently are compared in the paper. The feasibility and effectiveness are verified by an example of a cassegrain space telescope. 2010 Copyright SPIE - The International Society for Optical Engineering.
Non-uniformity correction in multi-CCD imaging system (EI CONFERENCE)
会议论文
2010 2nd International Conference on Mechanical and Electronics Engineering, ICMEE 2010, August 1, 2010 - August 3, 2010, Kyoto, Japan
Tao M.
;
Ren J.
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  |  
浏览/下载:16/0
  |  
提交时间:2013/03/25
The non-uniformity phenomenon exists in each channel of multi-CCD imaging systems. The factors which lead to the problem are complex. The conventional calibrating algorithms can not consider all of these factors and have poor effects. According to the characters of multi-CCD imaging systems
a non-uniformity correction method based on the scene was proposed by adopting the traditional two-point correction theories. The correction coefficient of each channel image can be calculated via the linear relation between the two neighboring pixel lines in the two-channel images. Compared with the conventional two-point calibration and multi-point calibration methods
contrastive calibrating results were obtained. This method does not need any standard lighted image as reference source
which provides a real time way for calibrating the multi-CCD imaging systems in practical applications. 2010 IEEE.
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