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Decreased expression of LncRNA SRA1 in hepatocellular carcinoma and its clinical significance 期刊论文
CANCER BIOMARKERS, 2017, 卷号: 18, 期号: 3
作者:  Tu, Jian-Cheng
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/05
PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice 期刊论文
BIOMOLECULES & THERAPEUTICS, 2016, 卷号: 24, 页码: 40-48
作者:  Ye, Nanhui;  Wang, Hang;  Hong, Jing;  Zhang, Tao;  Lin, Chaotong
收藏  |  浏览/下载：2/0  |  提交时间：2019/11/21
Molecular cloning and functional characterization of cyclin E and CDK2 from Penaeus monodon 期刊论文
GENETICS AND MOLECULAR RESEARCH, 2016, 卷号: 15, 期号: 3
作者:  Zhao, C.[1];  Fu, M. J.[2];  Qiu, L. H.[3]
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/02
Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep 期刊论文
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 卷号: 2016, 页码: 9151290
作者:  Deng, Shoulong;  Yu, Kun;  Wu, Qian;  Li, Yan;  Zhang, Xiaosheng
收藏  |  浏览/下载：16/0  |  提交时间：2019/12/30
Antioxidants  Bacteria  Enzymes  Gene expression  Oxygen  Peptides  Plants (botany)  Polymerase chain reaction  Anti-oxidant activities  Anti-oxidative enzymes  Glutathione peroxidase  Gram-negative bacteria  Innate immune systems  Lipopolysaccharides  Super oxide dismutase  Toll-like receptor 4  Chemical activation  catalase  copper zinc superoxide dismutase  cyclooxygenase 2  glutamate cysteine ligase  glutathione  glutathione peroxidase  glutathione transferase alpha  glutathione transferase alpha 1  heme oxygenase 1  lipopolysaccharide  malonaldehyde  messenger RNA  oxygen radical  reduced nicotinamide adenine dinucleotide phosphate oxidase  toll like receptor 4  transcription factor AP 1  unclassified drug  glutamate cysteine ligase  glutathione  glutathione peroxidase  lipopolysaccharide  toll like receptor 4  transcription factor AP 1  animal cell  animal experiment  animal tissue  Article  cell infiltration  cell stress  controlled study  down regulation  enzyme activation  enzyme activity  gene dosage  gene overexpression  genetic transcription  genome  glutathione metabolism  in vivo study  inflammation  inflammatory cell  inflammatory infiltrate  mediator release  monocyte  nonhuman  oxidative stress  protein blood level  protein expression  protein induction  signal transduction  transgenic sheep  upregulation  animal  biosynthesis  drug effects  gene expression regulation  genetics  metabolism  oxidative stress  sheep  transgenic animal  Animals  Animals  Genetically Modified  Gene Expression Regulation  Glutamate-Cysteine Ligase  Glutathione  Glutathione Peroxidase  Lipopolysaccharides  Oxidative Stress  Sheep  Toll-Like Receptor 4  Transcription Factor AP-1  
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.  
The effect of TGF-beta-induced epithelial mesenchymal transition on the expression of intracellular calcium-handling proteins in T47D and MCF-7 human breast cancer cells 期刊论文
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2015
Mahdi, Shah H. A.; Cheng, Huanyi; Li, Jinfeng; Feng, Renqing
收藏  |  浏览/下载：2/0  |  提交时间：2017/12/03
Regulatory role of nucleophosmin during the differentiation of human liver cancer cells 期刊论文
http://dx.doi.org/10.3892/ijo.2014.2407, 2014
Xu, Dong-Hui; Liu, Fan; Li, Xiao; Chen, Xiang-Feng; Jing, Guang-Jun; Wu, Fu-Yun; Shi, Song-Lin; Li, Qi-Fu; 石松林; 李祺福
收藏  |  浏览/下载：5/0  |  提交时间：2015/07/22
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
收藏  |  浏览/下载：28/0  |  提交时间：2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
Differential expressions of PDGF-BB and their distributions in PDGF-BB down-regulated transgenic mouse. 期刊论文
BIOMEDICAL RESEARCH-INDIA, 2013, 卷号: 24, 期号: 1
作者:  XiYang, Yan-Bin;  Ya-Zhao;  Lu, Bing-Tuan;  Ru, Jin;  Zhang, Wei
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/04
Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells 期刊论文
phytotherapy research, 2013, 卷号: 27, 期号: 3, 页码: 397-403
Zhang YX; Li QS; Ge YK; Chen YP; Chen J; Dong Y; Shi W
收藏  |  浏览/下载：13/0  |  提交时间：2014/04/16

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