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科研机构
北京大学 [7]
厦门大学 [6]
金属研究所 [2]
复旦大学上海医学院 [2]
长春应用化学研究所 [2]
清华大学 [1]
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期刊论文 [32]
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2016 [3]
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Decreased expression of LncRNA SRA1 in hepatocellular carcinoma and its clinical significance
期刊论文
CANCER BIOMARKERS, 2017, 卷号: 18, 期号: 3
作者:
Tu, Jian-Cheng
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Long non-coding RNA
SRA1
HCC
down-expression
PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice
期刊论文
BIOMOLECULES & THERAPEUTICS, 2016, 卷号: 24, 页码: 40-48
作者:
Ye, Nanhui
;
Wang, Hang
;
Hong, Jing
;
Zhang, Tao
;
Lin, Chaotong
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/11/21
I kappa B alpha expression
Liver inflammation
Pregnane X receptor
Ginkgolide A
PXR knock-down
Molecular cloning and functional characterization of cyclin E and CDK2 from Penaeus monodon
期刊论文
GENETICS AND MOLECULAR RESEARCH, 2016, 卷号: 15, 期号: 3
作者:
Zhao, C.[1]
;
Fu, M. J.[2]
;
Qiu, L. H.[3]
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/02
Cell cycle
Cyclin E/CDK2 complex
Prokaryotic expression
Pull-down
Penaeus monodon
Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep
期刊论文
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 卷号: 2016, 页码: 9151290
作者:
Deng, Shoulong
;
Yu, Kun
;
Wu, Qian
;
Li, Yan
;
Zhang, Xiaosheng
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/30
Antioxidants
Bacteria
Enzymes
Gene expression
Oxygen
Peptides
Plants (botany)
Polymerase chain reaction
Anti-oxidant activities
Anti-oxidative enzymes
Glutathione peroxidase
Gram-negative bacteria
Innate immune systems
Lipopolysaccharides
Super oxide dismutase
Toll-like receptor 4
Chemical activation
catalase
copper zinc superoxide dismutase
cyclooxygenase 2
glutamate cysteine ligase
glutathione
glutathione peroxidase
glutathione transferase alpha
glutathione transferase alpha 1
heme oxygenase 1
lipopolysaccharide
malonaldehyde
messenger RNA
oxygen radical
reduced nicotinamide adenine dinucleotide phosphate oxidase
toll like receptor 4
transcription factor AP 1
unclassified drug
glutamate cysteine ligase
glutathione
glutathione peroxidase
lipopolysaccharide
toll like receptor 4
transcription factor AP 1
animal cell
animal experiment
animal tissue
Article
cell infiltration
cell stress
controlled study
down regulation
enzyme activation
enzyme activity
gene dosage
gene overexpression
genetic transcription
genome
glutathione metabolism
in vivo study
inflammation
inflammatory cell
inflammatory infiltrate
mediator release
monocyte
nonhuman
oxidative stress
protein blood level
protein expression
protein induction
signal transduction
transgenic sheep
upregulation
animal
biosynthesis
drug effects
gene expression regulation
genetics
metabolism
oxidative stress
sheep
transgenic animal
Animals
Animals
Genetically Modified
Gene Expression Regulation
Glutamate-Cysteine Ligase
Glutathione
Glutathione Peroxidase
Lipopolysaccharides
Oxidative Stress
Sheep
Toll-Like Receptor 4
Transcription Factor AP-1
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling
期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:
Zhang, Lei
;
Xu, Xuan
;
Yang, Ruhao
;
Chen, Jingwen
;
Wang, Shixuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However
the underlying molecular mechanism remains unclear. In this study
we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3
and inhibited the expression of fibronectin
alpha-smooth muscle actin (α-SMA)
and collagen I in cultured NRK-49F cells. S3I-201
an STAT3 inhibitor
also suppressed the expression of fibronectin
α-SMA
and collagen I in cultured NRK-49F cells. Mechanistically
paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore
paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin
α-SMA
and collagen I
and suppressed the infiltration of macrophages and production of TNF-α
IL-1β
TGF-β
and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation
consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis
and inhibition of proinflammatory cytokine production.
The effect of TGF-beta-induced epithelial mesenchymal transition on the expression of intracellular calcium-handling proteins in T47D and MCF-7 human breast cancer cells
期刊论文
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2015
Mahdi, Shah H. A.
;
Cheng, Huanyi
;
Li, Jinfeng
;
Feng, Renqing
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2017/12/03
Breast cancer
TGF-beta
EMT
Calcium channel
Calcium pump
NCX
GENE-EXPRESSION
DOWN-REGULATION
E-CADHERIN
CA2+
CHANNELS
PUMPS
CARCINOMA
UNIPORTER
INVASION
STORE
Regulatory role of nucleophosmin during the differentiation of human liver cancer cells
期刊论文
http://dx.doi.org/10.3892/ijo.2014.2407, 2014
Xu, Dong-Hui
;
Liu, Fan
;
Li, Xiao
;
Chen, Xiang-Feng
;
Jing, Guang-Jun
;
Wu, Fu-Yun
;
Shi, Song-Lin
;
Li, Qi-Fu
;
石松林
;
李祺福
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/07/22
ACID-INDUCED DIFFERENTIATION
NUCLEAR-MATRIX PROTEINS
LEUKEMIA HL-60 CELLS
RETINOIC ACID
C-MYC
DOWN-REGULATION
EXPRESSION
B23
DECREASES
APOPTOSIS
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
Differential expressions of PDGF-BB and their distributions in PDGF-BB down-regulated transgenic mouse.
期刊论文
BIOMEDICAL RESEARCH-INDIA, 2013, 卷号: 24, 期号: 1
作者:
XiYang, Yan-Bin
;
Ya-Zhao
;
Lu, Bing-Tuan
;
Ru, Jin
;
Zhang, Wei
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/04
PDGF-BB
down-regulation
transgenic mouse
expression
distribution
Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells
期刊论文
phytotherapy research, 2013, 卷号: 27, 期号: 3, 页码: 397-403
Zhang YX
;
Li QS
;
Ge YK
;
Chen YP
;
Chen J
;
Dong Y
;
Shi W
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2014/04/16
DOWN-REGULATING SURVIVIN
SILYBUM-MARIANUM
CANCER CELLS
L GAERTN
CARCINOMA
SILYMARIN
P53
INHIBITION
EXPRESSION
PATHWAY
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