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Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 13
作者:
Jiang, Bo
;
Luo, Jiao
;
Guo, Shuju
;
Wang, Lijun
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/05/11
Type 2 diabetes mellitus
Protein tyrosine phosphatase 1B inhibitors
Thiazolidinedione
Insulin signaling
Anti-diabetic activities
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204
作者:
Zhou, Ting-ting
;
Zhao, Tong
;
Ma, Fei
;
Zhang, Yi-nan
;
Jiang, Jing
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
type 2 diabetes mellitus
hepatic gluconeogenesis
AMPK signaling pathway
(E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)
4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)
prodrug
D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy
期刊论文
AGING-US, 2019, 卷号: 11, 期号: 14, 页码: 4943-4969
作者:
Yu, Lexiang
;
Chen, Yao
;
Xu, Yong
;
He, Tao
;
Wei, Yan
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2019/10/25
D-ribose
benfotiamine (BTMP)
cognitive impairment
type 1 diabetic encephalopathy
type 1 diabetes mellitus (T1DM)
diabetic encephalopathy
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2 ',3,3 '-Tetrabromo-4,4 ',5,5 '-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice
期刊论文
MOLECULAR PHARMACEUTICS, 2019, 卷号: 16, 期号: 5, 页码: 1839-1850
作者:
Li, Chao
;
Luo, Jiao
;
Guo, Shuju
;
Jia, Xiaoling
;
Guo, Chuanlong
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2019/08/28
type 2 diabetes mellitus
protein tyrosine phosphatase 1B
insulin resistance
hypoglycemic activity
dyslipidemia
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 848-852
作者:
Kong, Deyu
;
Guo, Shimeng
;
Yang, Yushe
;
Guo, Bin
;
Xie, Xin
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
FFA1 agonist
2,3-Dihydrobenzo[b][1,4]dioxine
Insulin secretion
Type 2 diabetes mellitus
Anagliptin ameliorates high glucose- induced endothelial dysfunction via suppression of NLRP3 inflammasome activation mediated by SIRT1
期刊论文
MOLECULAR IMMUNOLOGY, 2019, 卷号: 107
作者:
Jiang, Tiechao
;
Jiang, Dongli
;
Zhang, Lirong
;
Ding, Mei
;
Zhou, Hui
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  |  
浏览/下载:33/0
  |  
提交时间:2019/12/05
Type 2 diabetes mellitus
Anagliptin
NLRP3 infammasome
SIRT1
Endothelial dysfunciton
Exposing the Causal Effect of C-Reactive Protein on the Risk of Type 2 Diabetes Mellitus: A Mendelian Randomization Study (vol 9, 657, 2018)
期刊论文
FRONTIERS IN GENETICS, 2019, 卷号: 10
作者:
Cheng, Liang
;
Zhuang, He
;
Yang, Shuo
;
Jiang, Huijie
;
Wang, Song
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/05
C-reactive protein
type 2 diabetes mellitus
causal effect
genome-wide association studies
mendelian randomization
type 1 diabetes mellitus
Oral delivery of single-chain insulin (SCI-59) analog by bacterium-like particles (BLPs) induces oral tolerance and prevents autoimmune diabetes in NOD mice
期刊论文
IMMUNOLOGY LETTERS, 2019, 卷号: 214
作者:
Mao, Ruifeng
;
Chen, Yingying
;
Wu, Qian
;
Zhang, Tong
;
Diao, Enjie
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/05
Type 1 diabetes mellitus
NOD mice
Bacterium-like particles
Single-chain insulin
Oral tolerance
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice.
期刊论文
Acta pharmacologica Sinica, 2019
作者:
Ting-Ting Zhou
;
Tong Zhao
;
Fei Ma
;
Yi-Nan Zhang
;
Jing Jiang
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/13
(E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)
4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)
AMPK signaling pathway
hepatic gluconeogenesis
prodrug
type 2 diabetes mellitus
Association of diabetic ketoacidosis, severe hypoglycemia and glycemic control among children and young adults with type 1 diabetes mellitus treated with premixed versus basal-bolus insulin therapy
期刊论文
Biomedical Journal, 2019
作者:
Wei-Yu Chou
;
Yan-Rong Li
;
Wai Kin Chan
;
Szu-Tah Chen
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/13
Insulin
Diabetes
mellitus
Type
1
Diabetic
ketoacidosis
Hemoglobin
A1c
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