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上海药物研究所 [5]
辽宁师范大学 [2]
吉林大学白求恩第三医... [2]
西安交通大学 [1]
复旦大学上海医学院 [1]
沈阳自动化研究所 [1]
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期刊论文 [12]
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2011 [2]
2008 [3]
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How to determine cardiac ion channels targeted by drugs using the isolated rabbit ventricular wedge model
期刊论文
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2016, 卷号: 81, 期号: [db:dc_citation_issue], 页码: 161-170
作者:
Liu, Guizhi
;
Liu, Tong
;
Cohen, Daniel
;
Liu, Tengxian
;
Yan, Gan-Xin
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/02
Positive staircase response of contractility
Use-dependency
I-Kr blocker
Rabbit ventricular wedge assay
Tp-e/QT ratio
Drug safety
Potassium channel activator
QT-BCL slope
Calcium channel blocker
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 1, 页码: 105-110
作者:
Yue, Jin-feng
;
Qiao, Guan-hua
;
Liu, Ni
;
Chen, Xue-qin
;
Nan, Fa-jun
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clampbased high-throughput screening techniques
期刊论文
Acta Pharmacologica Sinica, 2016, 卷号: 37, 期号: 1, 页码: 105
作者:
Yue Jinfeng
;
Qiao Guanhua
;
Liu Ni
;
Chen Xueqin
;
Nan Fajun
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
POTASSIUM CHANNEL
KV7 CHANNELS
EPILEPSY
IDENTIFICATION
GENE
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin.
期刊论文
Fitoterapia, 2014, 卷号: Vol.99, 页码: 284-291
作者:
Jiang Y
;
Yu B
;
Wang X
;
Sui Y
;
Zhang Y
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/02/27
KEYWORDS:
Activator
CFTR
chloride
channel
Fluorescence
quenching
tests
Patch
clamp
Short-circuit
current
Tangeretin
The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands
期刊论文
CELL RESEARCH, 2013, 卷号: 23, 期号: 9, 页码: 1106-1118
作者:
Li, Ping
;
Chen, Zhuxi
;
Xu, Haiyan
;
Sun, Haifeng
;
Li, Hao
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
voltage-gated potassium channel
gating charge pathway
KCNQ2 activator
binding site
anti-epilepsy drug
Vascular Endothelial Growth Factor Modulates Voltage-Gated Na+ Channel Properties and Depresses Action Potential Firing in Cultured Rat Hippocampal Neurons
期刊论文
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2013, 卷号: 36, 期号: 4
作者:
Sun, Guang-chun
;
Ma, Yuan-yuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/19
vascular endothelial growth factor
whole-cell patch-clamp
Na+ channel
action potential firing
Flk-1 receptor antagonist
protein kinase C-activator
KCNQ1 potassium channel and its small molecular modulator
期刊论文
Chinese Journal of New Drugs and Clinical Remedies, 2013, 卷号: 32, 期号: 11, 页码: 843-849
作者:
Lan Xi
;
Li Min
;
Gao Zhaobing
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
KCNE
KCNQ1 potassium channel
KCNE
arrhythmia
action potentials
small molecular activator
high throughput screening
Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules
期刊论文
ACTA PHARMACOLOGICA SINICA, 2011, 卷号: 32, 期号: 6, 页码: 781-788
作者:
Zhou, Ping-zheng
;
Babcock, Joseph
;
Liu, Lian-qing
;
Li, Min
;
Gao, Zhao-bing
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Human ether-a-go-go related gene (hERG)
ion channel
long QT syndrome (LQTS)
activator
Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules
期刊论文
ACTA PHARMACOLOGICA SINICA, 2011, 卷号: 32, 期号: 6, 页码: 781-788
作者:
Liu LQ(刘连庆)
;
Li M(李密)
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2012/05/29
Human ether-a-go-go related gene (hERG)
ion channel
long QT syndrome (LQTS)
activator
Identification of natural coumarin compounds that rescue defective Delta F508-CFTR chloride channel gating
期刊论文
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2008, 卷号: 35, 期号: 8
作者:
Xu, Li-Na
;
Na, Wan-Li
;
Liu, Xin
;
Hou, Shu-Guang
;
Lin, Sen
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
activator
coumarins
cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel
cystic fibrosis
Delta F508 mutation
pharmacological therapy
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