×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
上海药物研究所 [13]
厦门大学 [9]
复旦大学上海医学院 [7]
北京大学 [4]
山东大学 [3]
上海生物化学与细胞生... [3]
更多...
内容类型
期刊论文 [54]
发表日期
2019 [3]
2018 [2]
2017 [5]
2016 [1]
2015 [4]
2014 [5]
更多...
学科主题
Biochemist... [3]
Neuroscien... [2]
Cell Biolo... [1]
Chemistry [1]
Pharmacolo... [1]
Science & ... [1]
更多...
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共54条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
发表日期升序
发表日期降序
作者升序
作者降序
提交时间升序
提交时间降序
题名升序
题名降序
Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR
期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 92
作者:
Fang, Wei-Shuo
;
Sun, De-yang
;
Yang, Shuang
;
Cheng, Chen
;
Moschke, Katrin
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Beta-secretase (BACE1)
STD-NMR
Luteolin
P-hydroxy-cinnamic acid
Noncompetitive inhibition
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
期刊论文
BBA - Molecular Basis of Disease, 2019, 卷号: Vol.1865 No.1, 页码: 161-180
作者:
Yuan, Chunling
;
Guo, Xiaoli
;
Zhou, Qifan
;
Du, Fangyu
;
Jiang, Wei
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/12/17
ALZHEIMER'S
disease
*MILD
cognitive
impairment
*SECRETASE
inhibitors
*AMYLOID
beta-protein
precursor
*SMALL
molecules
Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR
期刊论文
2019, 卷号: 92, 页码: 103253
作者:
Fang Wei-Shuo
;
Sun De-Yang
;
Yang Shuang
;
Cheng Chen
;
Moschke Katrin
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/01/03
Beta-secretase (BACE1)
Luteolin
Noncompetitive inhibition
P-hydroxy-cinnamic acid
STD-NMR
Iron dysregulates APP processing accompanying with sAPP alpha cellular retention and beta-secretase inhibition in rat cortical neurons
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 177-183
作者:
Chen, Yu-ting
;
Chen, Wu-yan
;
Huang, Xiao-tian
;
Xu, Ye-chun
;
Zhang, Hai-yan
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
iron
neurons
amyloid precursor protein
sAPP alpha
beta-amyloid
beta-secretase
Alzheimer's disease
Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer
期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431
作者:
Wang, Xin
;
Pei, Gang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/04/28
Amyloid Precursor Protein
Beta-secretase
App
Site
Cleavage
Adam10
Bace1
Localization
Dimerization
Endocytosis
Defining the minimum substrate and charge recognition model of gamma-secretase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424
作者:
Yan, Yan
;
Xu, Ting-Hai
;
Melcher, Karsten
;
Xu, H. Eric
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Alzheimer's disease
amyloid beta (A beta)
amyloid precursor protein (APP)
C99, gamma-secretase
minimum substrate
Notch protein
recognition model
Antiamyloidogenic Activity of A beta 42-Binding Peptoid in Modulating Amyloid Oligomerization
期刊论文
SMALL, 2017
Zhao, Zijian
;
Zhu, Ling
;
Li, Haiyun
;
Cheng, Peng
;
Peng, Jiaxi
;
Yin, Yudan
;
Yang, Yang
;
Wang, Chen
;
Hu, Zhiyuan
;
Yang, Yanlian
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2017/12/04
aggregation,amyloid oligomerization,antiamyloidogenic,inhibitor,peptoids
GAMMA-SECRETASE INHIBITORS
SMALL-MOLECULE INHIBITORS
ALZHEIMERS-DISEASE
BETA-PEPTIDE
FIBRIL FORMATION
PROTEIN AGGREGATION
MOUSE MODEL
MECHANISM
NEUROTOXICITY
CONFORMATION
Initial Substrate Binding of gamma-Secretase: The Role of Substrate Flexibility
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 页码: 1279-1290
作者:
Li, Shu[1]
;
Zhang, Wan[1]
;
Han, Wei[1]
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/04/24
gamma-Secretase
amyloid precursor protein
amyloid-beta peptide
intramembrane protease
substrate recognition
notch signal
Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression
期刊论文
Molecular Medicine Reports, 2017, 卷号: 15, 期号: 2, 页码: 712-718
作者:
Zhao, Xue-Shan
;
Wu, Qi
;
Peng, Juan
;
Pan, Li-Hong
;
Ren, Zhong
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/27
hyperlipidemia
apoptosis
Alzheimer's disease
proprotein convertase subtilisin/kexin type 9
beta-secretase 1
amyloid beta-protein
amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 9, 页码: 1205
作者:
Chen Guofang
;
Xu Tinghai
;
Yan Yan
;
Zhou Yuren
;
Jiang Yi
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/07/01
BLOOD-BRAIN-BARRIER
INSULIN-DEGRADING ENZYME
SOLID-STATE NMR
NICOTINIC ACETYLCHOLINE-RECEPTORS
METABOTROPIC GLUTAMATE RECEPTORS
ATOMIC-FORCE MICROSCOPY
GAMMA-SECRETASE COMPLEX
SMOOTH-MUSCLE-CELLS
AMELIORATES MEMORY IMPAIRMENT
ENDOTHELIN-CONVERTING ENZYME
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
©版权所有 ©2017 CSpace - Powered by
CSpace