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Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7
作者:
Bi, Xiaoyang
;
Chen, Yu
;
Sun, Zhongya
;
Lu, Wenchao
;
Xu, Pan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Drug design
CBP
Bromodomain
Inhibitor
Acute myeloid leukemia
Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11
作者:
Chen, Yu
;
Bi, Xiaoyang
;
Zhang, Fengcai
;
Sun, Zhongya
;
Xu, Pan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
In silico screening
Drug design
CBP
Bromodomain
Inhibitor
Acute Myeloblastic Leukemia
Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemia
期刊论文
EXPERIMENTAL CELL RESEARCH, 2020, 卷号: 393
作者:
Chen, Cheng
;
Wang, Li
;
Li, Lili
;
Wang, Aoli
;
Huang, Tao
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  |  
浏览/下载:32/0
  |  
提交时间:2020/11/26
Acute myeloid leukemia (AML)
Drug response
Gene mutations
Single-cell RNA sequencing of t(8;21) acute myeloid leukemia for risk prediction
期刊论文
ONCOLOGY REPORTS, 2020, 卷号: 43, 期号: 4, 页码: 1278-1288
作者:
Xiong, Qian
;
Huang, Sai
;
Li, Yong-Hui
;
Lv, Na
;
Lv, Chao
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2020/12/10
acute myeloid leukemia
t(8
21)
single-cell RNA-sequencing
prognosis
The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Hao, Bing-bing
;
Li, Xiao-jing
;
Jia, Xing-long
;
Wang, Yu-xing
;
Zhai, Lin-hui
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/07/01
immunomodulatory drugs (IMiDs)
CC-885
BNIP3L
mitophagy
CRBN
acute myeloid leukemia
mitochondria-targeting drugs
The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein-Protein Interaction
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 33, 页码: 5530-5542
作者:
Ye, Xiaoqing
;
Chen, Gang
;
Jin, Jia
;
Zhang, Binzhong
;
Wang, Yinda
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/12/24
WDR5
MLL1
histone methyltransferase
small-molecular inhibitor
epigenetics
human acute leukemia
Clonal Evolution of Acute Myeloid Leukemia with CEBPA Double Mutations after Long-Term Remission: Case Report and a Literature Review
期刊论文
TURKISH JOURNAL OF HEMATOLOGY, 2019, 卷号: 36, 期号: 2
作者:
Su, Long
;
Li, Ying
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/12/05
Acute myeloid leukemia
CEBPA mutations
Next-generation sequencing
Clonal evolution
Relapse
The Impact of DNMT3A/FLT3-ITD/NPM1 on Patients with Acute Myeloid Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation
期刊论文
TURKISH JOURNAL OF HEMATOLOGY, 2019, 卷号: 36, 期号: 1
作者:
Su, Long
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/12/05
Acute myeloid leukemia
Genetic mutations
DNMT3A
FLT3-ITD
NPM1
Low Expression of Pseudogene POU5F1B Affects Diagnosis and Prognosis in Acute Myeloid Leukemia (AML)
期刊论文
MEDICAL SCIENCE MONITOR, 2019, 卷号: 25
作者:
Yi, Jing
;
Zhou, Ling-yu
;
Yi, Yun-yun
;
Zhu, Xin
;
Su, Xiao-yu
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
Biological Markers
Diagnosis
Leukemia, Myeloid, Acute
Prognosis
Pseudogenes
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