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科研机构
上海药物研究所 [5]
内容类型
期刊论文 [5]
发表日期
2019 [2]
2014 [1]
2012 [1]
2010 [1]
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Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia
期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:
Wu Chenglin
;
Xi Cong
;
Tong Junhua
;
Zhao Jing
;
Jiang Hualiang
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2020/07/01
DOPAMINE D-1
BERBERINE
EXPRESSION
INHIBITORS
IDENTIFICATION
CHOLESTEROL
MUTATIONS
LDLR
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D-1, D-2 and serotonin 5-HT1A multiple action profiles
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 21, 页码: 5838-5846
作者:
Li, Zeng
;
Huang, Jiye
;
Sun, Haifeng
;
Zhou, Shengbin
;
Guo, Lin
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
l-SPD
Tetrahydroprotoberberine
Dopamine receptor
Serotonin receptor
Multiple action
Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D-1 receptor
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 卷号: 20, 期号: 15, 页码: 4862-4871
作者:
Qian, Wangke
;
Lu, Weijian
;
Sun, Haifeng
;
Li, Zeng
;
Zhu, Liyuan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Tetrahydroprotoberberine
Dopamine receptor
Anti-substance abuse
Antagonist
TOTAL SYNTHESIS OF (S)-(-)-STEPHOLIDINE USING (S)-TERT-BUTANESULFINYLIMINE
期刊论文
HETEROCYCLES, 2010, 卷号: 81, 期号: 11, 页码: 2581-2592
作者:
Cheng, Jianjun
;
Fu, Liqiang
;
Ling, Chenyu
;
Yang, Yushe
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Tetrahydroprotoberberine
Stepholidine
Total Synthesis
Sulfinylimine
Schizophrenia
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