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Third-generation EGFR inhibitor HS-10296 in combination with famitinib, a multi-targeted tyrosine kinase inhibitor, exerts synergistic antitumor effects through enhanced inhibition of downstream signaling in EGFR-mutant non-small cell lung cancer cells
期刊论文
THORACIC CANCER, 2021, 页码: 9
作者:
Zhang, Mi
;
Quan, Haitian
;
Fu, Li
;
Li, Yun
;
Fu, Haoyu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
EGFR‐
mutant non‐
small cell lung cancer
famitinib
HS‐
10296
multi‐
targeted tyrosine kinase inhibitor
third‐
generation EGFR inhibitor
DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Dai, Meng-di
;
Wang, Yue-liang
;
Fan, Jun
;
Dai, Yang
;
Ji, Yin-chun
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/05/24
receptor tyrosine kinase
FGFR inhibitor
DW14383
antitumor activity
Efficacy of Pyrotinib in HER2-Overexpressing Salivary Duct Carcinoma With Lung Metastasis: A Case Report
期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:
Yang, Zi-yan
;
Huang, Jia-huan
;
Chen, Bo
;
Xu, Chun-wei
;
Lei, Lei
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/11/30
salivary duct carcinoma
tyrosine kinase inhibitor
pyrotinib
HER2 positive
targeted
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:
Lai, Meng-zhen
;
Song, Pei-ran
;
Dou, Dou
;
Diao, Yan-yan
;
Tong, Lin-jiang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton's tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
CT-Based Radiomic Signature as a Prognostic Factor in Stage IV ALK-Positive Non-small-cell Lung Cancer Treated With TKI Crizotinib: A Proof-of-Concept Study
期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10, 页码: 9
作者:
Li, Hailin
;
Zhang, Rui
;
Wang, Siwen
;
Fang, Mengjie
;
Zhu, Yongbei
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/04/07
computed tomography
radiomics
non-small-cell lung cancer
tyrosine kinase inhibitor resistance
anaplastic lymphoma kinase
discoveryandbiologicalevaluationofn372methoxy44methylpiperazin1ylphenylamino4methyl2oxo2hpyrimido45d13oxazin14hylphenylacrylamideaspotentbrutonstyrosinekinaseinhibitors
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 415
作者:
Lai Mengzhen
;
Song Peiran
;
Dou Dou
;
Diao Yanyan
;
Tong Linjiang
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton’s tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and and in vivo study
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 351-368
作者:
Wei, Peng
;
Liu, Bo
;
Wang, Ruifeng
;
Gao, Yinglei
;
Li, Lanlan
收藏
  |  
浏览/下载:109/0
  |  
提交时间:2020/07/01
Fibroblast growth factor
Tyrosine kinase receptor
Structure-based
Crystallography
Selectivity
Hybrid
5-Hydrosulfonyl-5H- pyrrolo[2.3-b]pyrazine
Inhibitor
Survival and intracranial control outcomes of whole-brain radiotherapy (WBRT) alone versus WBRT plus a radiotherapy boost in non-small-cell lung cancer with brain metastases: a single-institution retrospective analysis
期刊论文
CANCER MANAGEMENT AND RESEARCH, 2019, 卷号: 11
作者:
Lu, Fei
;
Hou, Yu
;
Xia, Yaoxiong
;
Li, Lan
;
Wang, Li
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/04
non-small-cell lung carcinoma
brain metastases
brain radiotherapy
radiotherapy boost
tyrosine kinase inhibitor
The Unique Spatial-Temporal Treatment Failure Patterns of Adjuvant Gefitinib Therapy: A Post Hoc Analysis of the ADJUVANT Trial (CTONG 1104)
期刊论文
JOURNAL OF THORACIC ONCOLOGY, 2019, 卷号: 14, 期号: 3
作者:
Xu, Song-Tao
;
Xi, Jun-Jie
;
Zhong, Wen-Zhao
;
Mao, Wei-Min
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/12/05
NSCLC
EGFR
tyrosine kinase inhibitor
gefitinib
adjuvant chemotherapy
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