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A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:
Qian, Hongjie
;
Chen, Qian
;
Lang, Liyu
;
Zou, Yang
;
Pu, Huahua
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/08/17
TPN171H
PDE5 inhibitor
safety
pharmacokinetics
food effect
healthy subjects
Liquid chromatography-tandem mass spectrometric assay for TPN171 in human plasma
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 191, 页码: 8
作者:
Zhang, Mengqi
;
Liu, Haiming
;
He, Jiajin
;
Gui, Yuzhou
;
Qian, Hongjie
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/12/24
TPN171
LC-MS/MS
Human plasma
Protein precipitation
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
Simultaneous determination of TPN729 and its five metabolites in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry
期刊论文
2018, 卷号: 151, 页码: 91-105
作者:
Liu, Yang
;
Shao, Shuguang
;
Song, Hanlin
;
Yao, Xueting
;
Liu, Jie
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/03
TPN729 and metabolites
Human plasma and urine
LC-MS/MS
Characterization of TPN729 metabolites in humans using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 卷号: 117, 页码: 217-226
作者:
Zhu, Yunting
;
Li, Liang
;
Deng, Pan
;
Chen, Xiaoyan
;
Zhong, Dafang
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  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
TPN729
UPLC/Q-TOF MS
Metabolite identification
Metabolic pathways
Human
Sildenafil
Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 12, 页码: 1528-1536
作者:
Gao, Zhi-wei
;
Zhu, Yun-ting
;
Yu, Ming-ming
;
Zan, Bin
;
Liu, Jia
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 12
作者:
Gao, Zhi-wei
;
Zhu, Yun-ting
;
Yu, Ming-ming
;
Zan, Bin
;
Liu, Jia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/19
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528
作者:
Gao Zhiwei
;
Zhu Yunting
;
Yu Mingming
;
Zan Bin
;
Liu Jia
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
HUMAN DRUG CLEARANCE
PHOSPHODIESTERASE-5 INHIBITORS
CLINICAL PHARMACOKINETICS
ERECTILE DYSFUNCTION
TISSUE DISTRIBUTION
ORAL PHARMACOKINETICS
RECEPTOR ANTAGONIST
DIVERSE COMPOUNDS
IN-VIVO
ABSORPTION
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
1例新生儿TPN外渗的护理
会议论文
作者:
陈劼
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/19
TPN外渗
新生儿
护理
Development of a colloidal gold-immunochromatography assay to detect immunoglobulin G antibodies to Treponema pallidum with TPN17 and TPN47
期刊论文
Diagnostic Microbiology and Infectious Disease, 2010, 卷号: 68, 期号: 3, 页码: 193-200
作者:
Lin, Li-Rong
;
Fu, Zuo-Gen
;
Dan, Bing
;
Jing, Guang-Jun
;
Tong, Man-li
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/03
Colloidal gold-immunochromatography assay
Treponema pallidum
TPN17
TPN47
FTA-Abs
TP-IgG
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