mevalonate  lanosterol  sterol intermediates  3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation  sterol regulatory element-binding protein-2 cleavage  clustered regularly interspaced short palindromic repeats (CRISPR)  CRISPR associated protein 9 (Cas9)  sterol regulatory element-binding protein-2  

HepG2 cells  Hydrogen sulfide  Lipid metabolism  Low-density lipoprotein receptor  Phosphoinositide 3-kinase/protein kinase B  Proprotein convertase subtilisin/kexin type 9  Sterol regulatory element-binding protein 2  

A-type procyanidins  Oxidative stress  Glucose homeostasis  Type 2 diabetes  mTOR  ACC1  acetyl coenzyme A carboxylase 1  ACL  ATP-citrate lyase  ALT  alanine aminotransferase  AST  aspartate aminotransferase  AUC  area under curve  BAT  brown adipose tissue  FAS  fatty acid synthase  FFA  free fatty acid  FoxO3a  Forkhead box O3a  FoxO1a  Forkhead box O3a  PKCβ  protein kinase C β  mTOR  mechanistic target of rapamycin  HDL  high-density lipoprotein  GHbA1c  glycated hemoglobin A1c  GK  glucokinase  G-6-Pase  glucose-6-phosphatase  GLP-1  glucagon-like peptide-1  GSH-PX  total glutathione peroxidase  HOMA-IR  homeostatic model assessment of insulin resistance  LDHA  lactate dehydrogenase  LDL  low-density lipoprotein  LPOPC  oligomeric procyanidins of litchi pericarp  MDA  malondialdehyde  MnSOD  manganese superoxide dismutase  mTOR  mechanistic target of rapamycin  OGTT  oral glucose tolerance test  PDH  pyruvate dehydrogenase  PEPCK  phosphoenolpyruvate carboxykinase  PFK  phosphofructokinase  PK  pyruvate kinase  PKCβ  protein kinase C β  PPG  postprandial blood glucose  S6K1  S6 Kinase 1  PKCβ  protein kinase C β  RTK  receptor tyrosine kinase  SREBP-1c  sterol regulatory element-binding protein 1c  ACL  ATP-citrate lyase  ACC1  acetyl coenzyme A carboxylase 1  FAS  fatty acid synthase  SCD1  stearoyl CoA desaturase 1  STZ  streptozotocin  S6K1  S6 kinase 1  PPG  postprandial blood glucose  ROS  reactive oxygen species  TC  total cholesterol  TG  triacylglycerol  STZ  streptozotocin  T-AOC  total antioxidant capacity  T-SOD  total superoxide dismutase  UCP-1  uncoupling protein 1  WAT  white adipose tissue  XOS  xylo-oligosaccharides  

sterol regulatory element binding protein 2  inflammasomes  microRNA-92  oxidative stress  endothelium  

ABCA1  ATP-binding cassette transporter A1  Atherosclerosis  COX-2  Cholesterol  DHC  ER  ERK1/2  LDL  LDL-C  LDL-cholesterol  LDLR  LE/LY  LXR  N-terminal domain  NPC1  NPC2  NTD  Niemann-Pick type C1  ORP5  OSBP  OSBP-related protein 5  PPARalpha  SREBP  SSD  TGN  apoA-I  apoE  apolipoprotein A-I  apolipoprotein E  cyclooxygenase-2  dihydrocapsaicin  endoplasmic reticulum  extracellular signal-regulated kinase 1/2  late endosome/lysosome  liver X receptor  low-density lipoprotein  low-density lipoprotein receptor  oxLDL  oxidized low-density lipoprotein  oxysterol-binding protein  peroxisome proliferator-activated receptor alpha  sterol regulatory element-binding protein  sterol-sensing domain  trans-Golgi network