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科研机构
江苏大学 [3]
中国医学科学院 北京... [2]
南华大学 [1]
北京大学 [1]
西安交通大学 [1]
中南大学 [1]
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期刊论文 [13]
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2019 [3]
2018 [2]
2017 [2]
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Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the Sirt1-eNOS pathway
期刊论文
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2019, 卷号: 33, 期号: 2
作者:
Zhai, Jinghui
;
Qu, Xiaoyu
;
Zhang, Yueming
;
Gao, Huan
;
Tao, Lina
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/05
cardiovascular disease (CVD)
high glucose
salvianolic acid (SA)
Sirtuin 1 (Sirt1)
High-glucose treatment regulates biological functions of human umbilical vein endothelial cells via Sirt1/FOXO3 pathway
期刊论文
ANNALS OF TRANSLATIONAL MEDICINE, 2019, 卷号: 7, 期号: 9
作者:
Chen, Yihui
;
Wang, Yan
;
Jiang, Yaping
;
Zhang, Xiaoyan
;
Sheng, Minjie
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/05
Sirtuin1 (Sirt1)
forkhead box O3 (FOXO3)
hyperglycaemia
vascular endothelial cells
peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha)
Long noncoding RNAs C2dat1 enhances vascular smooth muscle cell proliferation and migration by targeting MiR-34a-5p
期刊论文
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 卷号: 120, 期号: 3
作者:
Wang, Hairong
;
Jin, Zhili
;
Pei, Tu
;
Song, Wenhao
;
Gong, Yao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
CAMK2D-associated transcript 1 (C2dat1)
coronary artery disease (CAD)
long noncoding RNAs (lncRNAs)
miR-34a
sirtuin 1 (SIRT1)
vascular smooth muscle cell (VSMCs)
Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK-eIF-2-CHOP pathway in the unfolded protein response
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 页码: 8614-8625
作者:
Kang, Xiaomin
;
Yang, Wei
;
Wang, Ruiqi
;
Xie, Tianping
;
Li, Huixia
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/11/26
bone growth
chondrocyte
PERK
unfolded protein response (UPR)
chondrogenesis
sirtuin 1 (SIRT1)
growth plate
endoplasmic reticulum stress (ER stress)
Exploration of the Fluorescent Properties and the Modulated Activities against Sirtuin Fluorogenic Assays of Chromenone-Derived Natural Products
期刊论文
2018, 卷号: 23, 期号: 5
作者:
Wen, Hui
;
Xue, Nina
;
Wu, Feng
;
He, Yujun
;
Zhang, Gang
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/03
chromenone
isoflavone
osthole
AMC
fluorescence
fluorogenic assay
sirtuin
SIRT1 activator
Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc
期刊论文
Redox Biology, 2017, 卷号: 13, 页码: 482-497
作者:
Yang, Shikun
;
Zhao, Li
;
Han, Yachun
;
Liu, Yu
;
Chen, Chao
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/03
DN
diabetic nephropathy
ROS
reactive oxygen species
HG
high-glucose
SIRT1
sirtuin-1
Ac-H3
acetyl-histone H3
STZ
streptozotocin
AMPK
AMP-activated protein kinase
ECM
extracellular matrix
Nox2
NADPH oxidase 2
EMT
tubular epithelial-mesenchymal transition
DAPI
4′,6-diamidino-2-phenylindole 9
DHE
dihydroethidium
NDRD
non-diabetic renal disease
H&E
hematoxylin-eosin
PAS
periodic acid-Schiff
PASM
periodic acid-silver methenamine
IHC
immunohistochemistry
MDA
malondialdehyde
ChIP
chromatin immunoprecipitation
TC
total cholesterol
BUN
blood urea nitrogen
FN
fibronectin
HBA1C
glycosylated hemoglobin
Scr
serum creatinine
TG
triglyceride
Probucol
Renal injury
Diabetic nephropathy
p66Shc
Bivalent SIRT1 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 2, 页码: 180-186
作者:
Wang, Juan[1]
;
Zang, Wenwen[2]
;
Liu, Jiajia[3]
;
Zheng, Weiping[4]
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/24
Bivalent
SIRT1
Sirtuin
Inhibitor
Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring N-epsilon-thioacetyl-lysine
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 21, 页码: 5234-5239
作者:
Chen, Di[1]
;
Zheng, Weiping[2]
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/24
Sirtuin
Inhibitor
SIRT1/2 dual inhibition
N-epsilon-thioacetyl-lysine
Cyclic peptide
Antiasthmatic Effects of Resveratrol in Ovalbumin-Induced Asthma Model Mice Involved in the Upregulation of PTEN
期刊论文
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2015, 卷号: 38, 期号: 4
作者:
Chen, Guo
;
Tang, JiHong
;
Ni, Zhenhua
;
Chen, Qingge
;
Li, Zhao
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
resveratrol
asthma
phosphatase and tensin homology deleted on chromosome ten
Sirtuin 1 (SIRT1)
Novel thiourea-based sirtuin inhibitory warheads
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 卷号: 25, 期号: 16, 页码: 3319-3324
作者:
Zang, Wenwen[1]
;
Hao, Yujun[2]
;
Wang, Zhenghe[3]
;
Zheng, Weiping[4]
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/24
Sirtuin
SIRT1
SIRT2
SIRT3
SIRT5
Deacetylation
Deacylation
Inhibitory warhead
N-epsilon-Methyl-thiocarbamoyl-lysine
N-epsilon-Carboxyethyl-thiocarbamoyl-lysine
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