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复旦大学上海医学院 [14]
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Antidiabetic and hepatoprotective activity of the roots of Calanthe fimbriata Franch.
期刊论文
Biomedecine & pharmacotherapie, 2019, 卷号: 111, 页码: 60-67
作者:
Peng Yajie
;
Gao Yang
;
Zhang Xiaoqing
;
Zhang Changlong
;
Wang Xinrui
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/11/19
STZ-induced diabetic mice
Diabetes
Mechanism of action
Hepatoprotection
Calanthe fimbriata
Synergistic interactions of catalpol and stachyose in STZ-HFD induced diabetic mice: Synergism in regulation of blood glucose, lipids, and hepatic and renal function
期刊论文
CHINESE HERBAL MEDICINES, 2019, 卷号: Vol.11 No.1, 页码: 70-77
作者:
Chen, Xiao-fang
;
Liao, Deng-qun
;
Qin, Zhen-xian
;
Li, Xian-en
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/13
catalpol
high-sugar and high-fat diet
Rehmannia glutinosa Libosch
stachyose
STZ-induced diabetes
synergism
Synergistic interactions of catalpol and stachyose in STZ-HFD induced diabetic mice: Synergism in regulation of blood glucose, lipids, and hepatic and renal function
期刊论文
Chinese Herbal Medicines, 2019, 卷号: Vol.11 No.1, 页码: 70-77
作者:
Xiao-fang Chen
;
Deng-qun Liao
;
Zhen-xian Qin
;
Xian-en Li
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/17
catalpol
high-sugar
and
high-fat
diet
Rehmannia
glutinosa
Libosch
stachyose
STZ-induced
diabetes
synergism
Antidiabetic and hepatoprotective activity of the roots of Calanthe fimbriata Franch
期刊论文
2019, 卷号: 111, 页码: 60-67
作者:
Peng, Yajie
;
Gao, Yang
;
Zhang, Xiaoqing
;
Zhang, Changlong
;
Wang, Xinrui
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/01/03
Calanthe fimbriata
Diabetes
STZ-induced diabetic mice
Hepatoprotection
Mechanism of action
高能量饮食联合STZ诱导2型糖尿病肾病动物模型研究进展
期刊论文
2018, 卷号: 0, 期号: 92, 页码: 84-86
作者:
汪悦[1]
;
杨阳[1]
;
邬颖华[1]
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/16
高能量饮食
STZ
糖尿病肾病
动物模型
综述
The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2018, 卷号: 106, 页码: 1250-1257
作者:
Wang, Jinchun[1]
;
Wang, Lei[2]
;
Zhou, Jie[3]
;
Qin, Aiping[4]
;
Chen, Zhujing[5]
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/24
Formononetin
STZ
Cognitive impairment
HMGBL/TLR4/NF-kappa B signaling
NLRP3 inflammasome
Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice
期刊论文
Journal of Functional Foods, 2018, 卷号: 44, 页码: 155-165
作者:
Li, Xiaopeng
;
Wu, Qian
;
Sui, Yong
;
Li, Shuyi
;
Xie, Bijun
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/27
A-type procyanidins
Oxidative stress
Glucose homeostasis
Type 2 diabetes
mTOR
ACC1
acetyl coenzyme A carboxylase 1
ACL
ATP-citrate lyase
ALT
alanine aminotransferase
AST
aspartate aminotransferase
AUC
area under curve
BAT
brown adipose tissue
FAS
fatty acid synthase
FFA
free fatty acid
FoxO3a
Forkhead box O3a
FoxO1a
Forkhead box O3a
PKCβ
protein kinase C β
mTOR
mechanistic target of rapamycin
HDL
high-density lipoprotein
GHbA1c
glycated hemoglobin A1c
GK
glucokinase
G-6-Pase
glucose-6-phosphatase
GLP-1
glucagon-like peptide-1
GSH-PX
total glutathione peroxidase
HOMA-IR
homeostatic model assessment of insulin resistance
LDHA
lactate dehydrogenase
LDL
low-density lipoprotein
LPOPC
oligomeric procyanidins of litchi pericarp
MDA
malondialdehyde
MnSOD
manganese superoxide dismutase
mTOR
mechanistic target of rapamycin
OGTT
oral glucose tolerance test
PDH
pyruvate dehydrogenase
PEPCK
phosphoenolpyruvate carboxykinase
PFK
phosphofructokinase
PK
pyruvate kinase
PKCβ
protein kinase C β
PPG
postprandial blood glucose
S6K1
S6 Kinase 1
PKCβ
protein kinase C β
RTK
receptor tyrosine kinase
SREBP-1c
sterol regulatory element-binding protein 1c
ACL
ATP-citrate lyase
ACC1
acetyl coenzyme A carboxylase 1
FAS
fatty acid synthase
SCD1
stearoyl CoA desaturase 1
STZ
streptozotocin
S6K1
S6 kinase 1
PPG
postprandial blood glucose
ROS
reactive oxygen species
TC
total cholesterol
TG
triacylglycerol
STZ
streptozotocin
T-AOC
total antioxidant capacity
T-SOD
total superoxide dismutase
UCP-1
uncoupling protein 1
WAT
white adipose tissue
XOS
xylo-oligosaccharides
LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 8, 页码: 1104-1119
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Wang, Yi-yang
;
Xu, Xin
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
Alzheimer's disease
LX2343
cognitive deficits
oxidative stress
tauopathy
mitochondria
GSK-3 beta inhibitor
neuroprotection
ICV-STZ rats
Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc
期刊论文
Redox Biology, 2017, 卷号: 13, 页码: 482-497
作者:
Yang, Shikun
;
Zhao, Li
;
Han, Yachun
;
Liu, Yu
;
Chen, Chao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/12/03
DN
diabetic nephropathy
ROS
reactive oxygen species
HG
high-glucose
SIRT1
sirtuin-1
Ac-H3
acetyl-histone H3
STZ
streptozotocin
AMPK
AMP-activated protein kinase
ECM
extracellular matrix
Nox2
NADPH oxidase 2
EMT
tubular epithelial-mesenchymal transition
DAPI
4′,6-diamidino-2-phenylindole 9
DHE
dihydroethidium
NDRD
non-diabetic renal disease
H&E
hematoxylin-eosin
PAS
periodic acid-Schiff
PASM
periodic acid-silver methenamine
IHC
immunohistochemistry
MDA
malondialdehyde
ChIP
chromatin immunoprecipitation
TC
total cholesterol
BUN
blood urea nitrogen
FN
fibronectin
HBA1C
glycosylated hemoglobin
Scr
serum creatinine
TG
triglyceride
Probucol
Renal injury
Diabetic nephropathy
p66Shc
Antidiabetic activity and chemical constituents of the aerial parts of Heracleum dissectum Ledeb.
期刊论文
FOOD CHEMISTRY, 2017, 卷号: 214, 页码: 572-579
作者:
Zhang, Hailong
;
Su, Yaping
;
Wang, Xinrui
;
Mi, Jie
;
Huo, Yayu
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/11/26
Chemical constituents
STZ-induced diabetic model
Heracleum dissectum
Antidiabetes
Oral glucose tolerance test
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