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期刊论文 [48]
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Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists
期刊论文
PHARMACEUTICALS, 2022, 卷号: 15
作者:
Sun, Lei
;
Zheng, Zhi-Ming
;
Shao, Chang-Sheng
;
Zhang, Zhi-Yong
;
Li, Ming-Wei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/22
glucagon-like peptide-1
GLP-1 receptor agonist
functional protein design
molecular dynamics simulation
long-acting antihyperglycemic
Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190, 页码: 14
作者:
Chen, Yun
;
Bai, Gang
;
Ning, Yi
;
Cai, Shi
;
Zhang, Tao
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  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
lnterleukin-1 receptor associated kinase 4
Imidazol1,2-6]pyridazine
Diffuse large B-cell lymphoma
Drug design
Antitumor agents
Exploring the structural determinants of novel xanthine derivatives as A(2B) adenosine receptor antagonists: a computational study
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2019, 卷号: 37, 页码: 3467-3481
作者:
Yang, Yinfeng
;
Li, Yan
;
Zhou, Weiwei
;
Chen, Yaorong
;
Wu, Qian
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/02
A(2B) adenosine receptor
3D-QSAR
molecular docking
molecular dynamics
synthetic feasibility
drug design
Recent Trends and Applications of Molecular Modeling in GPCR-Ligand Recognition and Structure-Based Drug Design
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 7
作者:
Yuan, Xiaojing
;
Xu, Yechun
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  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
GPCR
receptor-ligand recognition
drug design
molecular modeling
molecular dynamics
docking
binding affinity
binding pathway
Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site
期刊论文
2018, 卷号: 9, 页码: 1419
作者:
Liu, Yangguang
;
Wu, Meng
;
Wang, Tianqi
;
Xie, Yongli
;
Cui, Xiangling
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  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
androgen receptor
structural based drug design
antiandrogen
castration-resistant prostate cancer
activation function-2
TRPM2: a potential drug target to retard oxidative stress.
期刊论文
Frontiers in bioscience (Landmark edition), 2017, 卷号: 22, 期号: 9, 页码: 1427-1438
作者:
Li, Jun
;
Gao, Yunling
;
Bao, Xianying
;
Li, Fengna
;
Yao, Wei
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/23
Transient receptor potential melastatin 2
Oxidative stress
Calcium-permeable channel
Drug design
Review
Bacterial chemoreceptors and chemoeffectors
期刊论文
CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 卷号: 72, 期号: 4, 页码: 691-708
作者:
Bi, Shuangyu
;
Lai, Luhua
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  |  
浏览/下载:19/0
  |  
提交时间:2019/04/09
Chemotactic Response
Receptor
Ligand
Molecular Mechanism
Receptor Design
Bacterial chemoreceptors and chemoeffectors
期刊论文
cellular and molecular life sciences, 2015
Bi, Shuangyu
;
Lai, Luhua
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  |  
浏览/下载:3/0
  |  
提交时间:2015/11/11
Chemotactic response
Receptor
Ligand
Molecular mechanism
Receptor design
COLI SERINE CHEMORECEPTOR
LIGAND-BINDING DOMAIN
DISULFIDE CROSS-LINKING
ESCHERICHIA-COLI
ASPARTATE RECEPTOR
HAMP DOMAIN
SIGNAL-TRANSDUCTION
CHEMOTAXIS RECEPTOR
MUTATIONAL ANALYSIS
SENSORY ADAPTATION
Progress in antiandrogen design targeting hormone binding pocket to circumvent mutation based resistance
期刊论文
2015, 卷号: 6
作者:
Tian, Xiaohong
;
He, Yang
;
Zhou, Jinming
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/01/13
androgen receptor
antiandrogen
drug resistance
mutation
rational drug design
Progress in antiandrogen design targeting hormone binding pocket to circumvent mutation based resistance (vol 6, 57, 2015)
期刊论文
2015, 卷号: 6
作者:
Tian, Xiaohong
;
He, Yang
;
Zhou, Jinming
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/13
androgen receptor
antiandrogen
drug resistance
mutation
rational drug design
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