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上海药物研究所 [18]
南华大学 [3]
河南大学 [3]
海洋研究所 [2]
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期刊论文 [36]
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Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Arylaminoacetylhydrazone Derivatives Containing Carbazole Moiety
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3157-3170
作者:
Li Yingjun
;
Lin Ledi
;
Jin Kun
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/11/04
protein tyrosine phosphatase 1B (PTP1B) inhibitor
carbazole
arylaminoacetylhydrazone
synthesis
molecular docking
3,6-二取代三唑并噻二唑衍生物的合成及其对细胞分裂周期25B磷酸酶和蛋白酪氨酸磷酸酶1B抑制活性评价
期刊论文
应用化学, 2020, 卷号: 37, 期号: 9, 页码: 994
作者:
李英俊
;
杨鸿境
;
曹欣
;
高立信
;
靳焜
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/12/24
triazolothiadiazole
benzimidazole
aryloxyacetic acid
cell division cycle 25B phosphatase inhibitor
protein tyrosine phosphatase 1B inhibitor
三唑并噻二唑
苯并咪唑
芳氧乙酸
细胞分裂周期25B磷酸酶抑制剂
蛋白酪氨酸磷酸酶1B抑制剂
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Aglaiabbrevins A-D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2017, 卷号: 65, 期号: 3, 页码: 295-299
作者:
Sun, Pan
;
Jiang, Chang-Sheng
;
Zhang, Yi
;
Liu, Ai -Hong
;
Liang, Tong -Jun
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Aglaia abbreviata
prenylated bibenzyl
aglaiabbrevin
protein tyrosine phosphatase-1B inhibitor
potential lead compound
Discovery of Bisindole as a Novel Scaffold for Protein Tyrosine Phosphatase 1B Inhibitors
期刊论文
ARCHIV DER PHARMAZIE, 2017, 卷号: 350, 期号: 1
作者:
Jing, Changcheng
;
Li, Ziyan
;
Jia, Kaili
;
Chen, Chen
;
Liu, Xiao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Inhibitor
Mixed 3,3 '-bisindoles
Molecular docking
Protein tyrosine phosphatase 1B
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y
期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:
Ma, Yun*
;
Tian, Shuai
;
He, Shuya*
;
Chen, Qiong
;
Wang, Zongbao
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/27
mRNA
messenger ribonucleic acid
miRNA
micro ribonucleic acid
TNF-α
tumor necrosis factor-alpha
SH-SY5Y
cells SH-SY5Y neuroblastoma cells
Ago2
Argonaute 2
USP32
ubiquitin specific peptidase 32
RAB18
member RAS oncogene family
Dusp6
dual specificity phosphatase 6
Cdkn1a
cyclin-dependent kinase inhibitor 1A
Bcl-2
B-cell lymphoma-2
FMRP
fragile X mental retardation protein
FXR1P
fragile X-related 1 protein
FXR2P
fragile X-related 2 protein
3′UTR
3′untranslated regions
CDS
coding sequence
FACS
fluorescence activated cell sorter
PMSF
phenylmethanesulfonyl fluoride
SDS-PAGE
sodium dodecyl sulfate-polyacrylamide gel electrophoresis
ANOVA
analysis of variance
SD
standard deviation
PCR
polymerase chain reaction
miR-19b
FXR1
RAB18
USP32
Dusp6
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y
期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:
Ma, Yun*
;
Tian, Shuai
;
He, Shuya*
;
Chen, Qiong
;
Wang, Zongbao
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/27
mRNA
messenger ribonucleic acid
miRNA
micro ribonucleic acid
TNF-α
tumor necrosis factor-alpha
SH-SY5Y
cells SH-SY5Y neuroblastoma cells
Ago2
Argonaute 2
USP32
ubiquitin specific peptidase 32
RAB18
member RAS oncogene family
Dusp6
dual specificity phosphatase 6
Cdkn1a
cyclin-dependent kinase inhibitor 1A
Bcl-2
B-cell lymphoma-2
FMRP
fragile X mental retardation protein
FXR1P
fragile X-related 1 protein
FXR2P
fragile X-related 2 protein
3′UTR
3′untranslated regions
CDS
coding sequence
FACS
fluorescence activated cell sorter
PMSF
phenylmethanesulfonyl fluoride
SDS-PAGE
sodium dodecyl sulfate-polyacrylamide gel electrophoresis
ANOVA
analysis of variance
SD
standard deviation
PCR
polymerase chain reaction
miR-19b
FXR1
RAB18
USP32
Dusp6
Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 15, 页码: 4891-4898
作者:
Du, Yongli
;
Ling, Hao
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B inhibitor
N-(2,5-Diethoxy-phenyl)-methanesulfonamide
Type 2 diabetes mellitus
Insulin signaling
Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 15
作者:
Du, Yongli
;
Ling, Hao
;
Zhang, Meng
;
Shen, Jingkang
;
Li, Qunyi
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/19
Protein tyrosine phosphatase 1B inhibitor
N-(2,5-Diethoxy-phenyl)-methanesulfonamide
Type 2 diabetes mellitus
Insulin signaling
Structure and biosynthesis of fumosorinone, a new protein tyrosine phosphatase 1B inhibitor firstly isolated from the entomogenous fungus Isaria fumosorosea
期刊论文
FUNGAL GENETICS AND BIOLOGY, 2015, 卷号: 81, 页码: 191-200
作者:
Liu, Linxia[1]
;
Zhang, Jun[2]
;
Chen, Chuan[3]
;
Teng, Jitao[4]
;
Wang, Chengshu[5]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/21
Natural product
Isaria fumosorosea
Fumosorinone
Protein tyrosine phosphatase 1B inhibitor
PKS-NPRS
Biosynthesis
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