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科研机构
北京大学 [5]
合肥物质科学研究院 [5]
西安交通大学 [2]
复旦大学上海医学院 [2]
清华大学 [1]
大连理工大学 [1]
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期刊论文 [18]
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2020 [2]
2018 [4]
2017 [2]
2016 [2]
2015 [1]
2014 [2]
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Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery
期刊论文
CHINESE CHEMICAL LETTERS, 2020, 卷号: 31
作者:
Li, Ying
;
Cao, Xiuxiu
;
Tian, Changlin
;
Zheng, Ji-Shen
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/07
Chemical protein synthesis
Mirror-image proteins
Mirror-image phage display
Mirror-image one-bead one-compound (OBOC)
D-Peptide drug
Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 卷号: 59
作者:
Qu, Qian
;
Gao, Shuai
;
Wu, Fangming
;
Zhang, Meng-Ge
;
Li, Ying
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/11/26
chemical protein synthesis
cyclic peptides
disulfides
native chemical ligation
peptides
Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis
期刊论文
SCIENCE CHINA-CHEMISTRY, 2018, 卷号: 61, 期号: 6, 页码: 702-707
作者:
Chen, Chen-Chen
;
Gao, Shuai
;
Ai, Hua-Song
;
Qu, Qian
;
Tian, Chang-Lin
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/08/23
protein chemical synthesis
calciseptine
hydrazide based native chemical ligation
racemic protein crystallography
Dynamic Description of the Catalytic Cycle of Malate Enzyme: Stereoselective Recognition of Substrate, Chemical Reaction, and Ligand Release
期刊论文
JOURNAL OF PHYSICAL CHEMISTRY B, 2018, 卷号: 122, 页码: 12241-12250
作者:
Pu, Zhongji
;
Zhao, Mengdi
;
Zhang, Yue
;
Sun, Wenhui
;
Bao, Yongming
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/02
Carboxylation
Chemical activation
Enzymes
Fatty acids
Hydrides
Ligands
Stereochemistry
Stereoselectivity
Substrates, Activation barriers
Catalytic transformation
Experimental investigations
Fatty acid synthesis
Protein engineering
Stereoselective recognition
Structural knowledge
Transition state theories, Biochemical engineering
Total Chemical Synthesis of Modified Histones
期刊论文
FRONTIERS IN CHEMISTRY, 2018, 卷号: 6
作者:
Qi, Yun-Kun
;
Ai, Hua-Song
;
Li, Yi-Ming
;
Yan, Baihui
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/11/26
total chemical synthesis
native chemical ligation
histones
post-translational modifications
protein chemical synthesis
Chemical synthesis and structural analysis of guanylate cyclase C agonist linaclotide
期刊论文
CHINESE CHEMICAL LETTERS, 2018, 卷号: 29
-
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/10/26
IRRITABLE-BOWEL-SYNDROME
RACEMIC PROTEIN CRYSTALLOGRAPHY
X-RAY STRUCTURES
GASTROINTESTINAL-TRACT
PREVALENCE
LIGATION
PATTERNS
IMPACT
Linaclotide
Guanylyl cyclase
Protein chemical synthesis
Fmoc solid phase peptide synthesis
Racemic crystallization
Chemical Synthesis of K34-Ubiquitylated H2B for Nucleosome Reconstitution and Single-Particle Cryo-Electron Microscopy Structural Analysis
期刊论文
CHEMBIOCHEM, 2017, 卷号: 18, 期号: 2, 页码: 176-180
作者:
Li, Jiabin
;
He, Qiaoqiao
;
Liu, Yuntao
;
Liu, Sanling
;
Tang, Shan
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2018/07/04
Cryo-electron Microscopy
Histone
Nucleosome
Protein Chemical Synthesis
Ubiquitylation
Rich Dynamics Underlying Solution Reactions Revealed by Sampling and Data Mining of Reactive Trajectories
期刊论文
ACS CENTRAL SCIENCE, 2017
Zhang, Jun
;
Zhang, Zhen
;
Yang, Yi Isaac
;
Liu, Sirui
;
Yang, Lijiang
;
Gao, Yi Qin
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2017/12/03
CHEMICAL-REACTIONS
CLAISEN REARRANGEMENT
TRANSITION-STATES
ORGANIC-SYNTHESIS
IN-WATER
ISOMERIZATION
MECHANICS
BARRIER
PROTEIN
MOTION
Small is Smarter: Nano MRI Contrast Agents - Advantages and Recent Achievements
期刊论文
SMALL, 2016, 卷号: 12, 期号: 5, 页码: 556-576
作者:
Gao, Zhenyu
;
Ma, Tiancong
;
Zhao, Enyu
;
Docter, Dominic
;
Yang, Wensheng
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2016/06/27
chemical synthesis
magnetic nanoparticles
protein coronas
surface modifications
tumor imaging
Cellular Synthesis of Protein Catenanes
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016
Wang, Xiao-Wei
;
Zhang, Wen-Bin
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2017/12/03
catenanes
protein structures
protein folding
supramolecular chemistry
topology
SPYTAG-SPYCATCHER CHEMISTRY
CHEMICAL-SYNTHESIS
CIRCULAR PROTEINS
NATURAL-PRODUCTS
PEPTIDE TAG
KNOTS
CYCLIZATION
STABILITY
CHAINS
FORMS
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