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科研机构
上海药物研究所 [6]
山东大学 [5]
中国医学科学院 北京... [1]
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期刊论文 [12]
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2019 [1]
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Synthesis of Novel Pyrazole Derivatives and Their Tumor Cell Growth Inhibitory Activity
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 2
作者:
Cui, Ying-Jie
;
Tang, Long-Qian
;
Zhang, Cheng-Mei
;
Liu, Zhao-Peng
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  |  
浏览/下载:122/0
  |  
提交时间:2019/12/11
privileged structure
pyrazoles
tubulin inhibitors
antitumor
antitumor agents
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 155, 页码: 714-724
作者:
Sun, Lin
;
Gao, Ping
;
Dong, Guanyu
;
Zhang, Xujie
;
Cheng, Xiqiang
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
HAART
HIV-1 dual inhibitors
HIV-1 IN
RNase H
5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives
Privileged
structure
Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2017, 卷号: 27, 期号: 11, 页码: 1277-1286
作者:
Cheng, Xiqiang
;
Gao, Ping
;
Sun, Lin
;
Tian, Ye
;
Zhan, Peng
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/12
AIDS
HIV-1
IN inhibitors
prodrug
privileged structure
drug design
1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 20, 页码: 5779-5789
作者:
Gao, Ping
;
Zhang, Lingzi
;
Sun, Lin
;
Huang, Tianguang
;
Tan, Jing
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  |  
浏览/下载:16/0
  |  
提交时间:2019/12/12
HIV-1
CuAAC
HIV-1 integrase
HIV-1 RNase H
"Privileged
structure"-guided scaffold reposition
Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds
期刊论文
2017, 卷号: 27, 期号: 15, 页码: 3326-3331
作者:
Zhou, Andong
;
Yan, Lei
;
Lai, Fangfang
;
Chen, Xiaoguang
;
Goto, Masuo
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/04
Indolin-2-one
Privileged structure
Cytotoxicity
Molecular mechanism
Rapid Generation of Privileged Substructure-Based Compound Libraries with Structural Diversity and Drug-Likeness
期刊论文
ACS COMBINATORIAL SCIENCE, 2014, 卷号: 16, 期号: 4, 页码: 184-191
作者:
Zhang, Lei
;
Zheng, Mingyue
;
Zhao, Fei
;
Zhai, Yun
;
Liu, Hong
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
indole
diversity-oriented synthesis
drug-like
privileged structure
microwave
A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo [2,1-f][1,2,4] triazin-4(3H)-ones
期刊论文
TETRAHEDRON, 2013, 卷号: 69, 期号: 13, 页码: 2714-2719
作者:
Chen, Yanhong
;
Xiang, Haoyue
;
Tan, Cun
;
Xie, Yuyuan
;
Yang, Chunhao
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Tandem annulation
Cupric chloride
1-Amino-1H-pyrrole-2-amides
Privileged structure
Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones
An integrated drug-likeness study for bicyclic privileged structures: from physicochemical properties to in vitro ADME properties
期刊论文
MOLECULAR DIVERSITY, 2011, 卷号: 15, 期号: 4, 页码: 857-876
作者:
Han, Chunyan
;
Zhang, Jinlan
;
Zheng, Mingyue
;
Xiao, Yao
;
Li, Yan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Physicochemical properties
Pharmacokinetic properties
Privileged structure
Drug-likeness
ADME
1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents
期刊论文
Mini reviews in medicinal chemistry, 2011, 卷号: 11, 期号: 13, 页码: 1130-1142
作者:
Z. Li
;
P. Zhan
;
X. Liu
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/23
1
3
4-Oxadiazole
privileged structure
solid-phase synthesis
antiviral activity
structural modification
molecule modeling.
One-pot Synthesis of 2,4-Diamino-substituted Thieno[3,2-d]pyrimidines
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2010, 卷号: 28, 期号: 8, 页码: 1437-1440
作者:
Li Xiaoying
;
Zhang Yangming
;
Tang Jie
;
Yang Fan
;
Nan Fajun
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
privileged structure
2,4-dichlorothieno[3,2-d]pyrimidine
one-pot
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