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科研机构
上海药物研究所 [6]
山东大学 [5]
中国医学科学院 北京... [4]
南华大学 [3]
生物物理研究所 [2]
四川大学 [2]
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期刊论文 [30]
学位论文 [1]
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2019 [4]
2018 [4]
2017 [3]
2016 [5]
2015 [2]
2014 [3]
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Chemistry [1]
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Design, synthesis and biological evaluation of novel, orally bioavailable pyrimidine-fused heterocycles as influenza PB2 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162
作者:
Xiong, Jian
;
Wang, Jingjing
;
Hu, Guoping
;
Zhao, Weili
;
Li, Jianqi
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/05
Influenza
Polymerase inhibitor
PB2
Drug design
Metabolic stability
A Parallel Phenotypic Versus Target-Based Screening Strategy for RNA-Dependent RNA Polymerase Inhibitors of the Influenza A Virus
期刊论文
VIRUSES-BASEL, 2019, 卷号: 11, 期号: 9
作者:
Zhao, Xiujuan
;
Wang, Yanyan
;
Cui, Qinghua
;
Li, Ping
;
Wang, Lin
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/11
Influenza A virus
phenotypic screen
target-based screen
RNA dependent
RNA polymerase inhibitor
A Parallel Phenotypic Versus Target-Based Screening Strategy for RNA-Dependent RNA Polymerase Inhibitors of the Influenza A Virus
期刊论文
Viruses, 2019, 卷号: 11, 期号: 9
作者:
Zhao X.
;
Wang Y.
;
Cui Q.
;
Li P.
;
Wang L.
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/11
Influenza A virus
phenotypic screen
RNA dependent RNA polymerase inhibitor
target-based screen
Identification and characterization of Zika virus NS5 RNA-dependent RNA polymerase inhibitors
期刊论文
2019, 卷号: 54, 期号: 4, 页码: 502-506
作者:
Lin Yuan
;
Zhang Hongjuan
;
Song Weibao
;
Si Shuyi
;
Han Yanxing
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/01/03
Inhibitor
NS5
RNA-dependent RNA polymerase
Zika virus
Sofosbuvir plus ribavirin with or without peginterferon for the treatment of hepatitis C virus: Results from a phase 3b study in China
期刊论文
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2018, 卷号: 33, 期号: 6
作者:
Wei, Lai
;
Xie, Qing
;
Hou, Jin Lin
;
Jia, Jidong
;
Li, Wu
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/12/04
direct-acting antiviral agents
NS5B polymerase inhibitor
pangenotypic
SVR12
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Sofosbuvir plus ribavirin with or without peginterferon for the treatment of hepatitis C virus: Results from a phase 3b study in China
期刊论文
Journal of Gastroenterology and Hepatology, 2018, 卷号: Vol.33 No.6, 页码: 1168-1176
作者:
Wei, L
;
Xie, Q
;
Hou, JL
;
Jia, JD
;
Li, W
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/02/25
direct‐acting antiviral agents
NS5B polymerase inhibitor
pangenotypic
SVR12
Sofosbuvir plus ribavirin with or without peginterferon for the treatment of hepatitis C virus: Results from a phase 3b study in China
期刊论文
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2018, 卷号: 33, 期号: 6, 页码: 1168-1176
作者:
Wei, Lai
;
Xie, Qing
;
Hou, Jin Lin
;
Jia, Jidong
;
Li, Wu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/11
direct-acting antiviral agents
NS5B polymerase inhibitor
pangenotypic
SVR12
Identification and Analysis of Novel Inhibitors against NS3 Helicase and NS5B RNA-Dependent RNA Polymerase from Hepatitis C Virus 1b (Con1)
期刊论文
FRONTIERS IN MICROBIOLOGY, 2017, 卷号: 8
作者:
Yang, Na
;
Sun, Chaomin
;
Zhang, Lixin
;
Liu, Jianguo
;
Song, Fuhang
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2018/01/11
Hepatitis c Virus
Ns3 Helicase
Ns5b Rna-dependent Rna Polymerase
High Throughput
Inhibitor
The expression of APE1 in triple-negative breast cancer and its effect on drug sensitivity of olaparib.
期刊论文
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, 卷号: 39, 期号: 10
作者:
Chen Tianran
;
Liu Chuan
;
Lu Heng
;
Yin Mingzhen
;
Shao Changjuan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
BER
Poly (ADP-ribose) polymerase 1 inhibitor
apurinic/apyrimidyl endonuclease 1
olaparib
triple-negative breast cancer
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