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Cinnamtannin D1 Protects Pancreatic beta-Cells from Glucolipotoxicity-Induced Apoptosis by Enhancement of Autophagy In Vitro and In Vivo
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 卷号: 68, 期号: 45, 页码: 12617-12630
作者:
Wang, Xin-Yi
;
Zhu, Bo-Rong
;
Jia, Qi
;
Li, Yi-Ming
;
Wang, Ting
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/05/24
cinnamtannin D1
pancreatic beta-cells
autophagy
apoptosis
type 2 diabetes
DGAT1 inhibitors protect pancreatic beta-cells from palmitic acid-induced apoptosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Huang, Jun-shang
;
Guo, Bin-bin
;
Wang, Gai-hong
;
Zeng, Li-min
;
Hu, You-hong
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/12/24
type 2 diabetes
DGAT1 inhibitors
pancreatic beta-cells
apoptosis
ER stress
inflammation
Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic beta-cells protective agents for the treatment of type 2 diabetes mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188, 页码: 17
作者:
Wang, Junwei
;
Lv, Xue
;
Xu, Jiawen
;
Liu, Xinpeng
;
Du, Te
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Type 2 diabetes mellitus
Pancreatic beta-cells protective agents
Vincamine derivatives
Structural modifications
Structure-activity relationships
Kras(G12D) mutation contributes to regulatory T cell conversion through activation of the MEK/ERK pathway in pancreatic cancer
期刊论文
CANCER LETTERS, 2019, 卷号: 446
作者:
Fan, Kun
;
Liu, Chen
;
Yu, Xianjun
;
Xu, Jin
;
Jin, Kaizhou
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/12/05
Pancreatic cancer
Immunosuppressive
Kras(G12D) mutation
IL-10
TGF-beta
Sequential Targeting TGF-beta Signaling and KRAS Mutation Increases Therapeutic Efficacy in Pancreatic Cancer
期刊论文
SMALL, 2019, 卷号: 15, 期号: 24
作者:
Pei, Yuanyuan
;
Chen, Liang
;
Huang, Yukun
;
Wang, Jiahao
;
Feng, Jingxian
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2019/12/05
KRAS
pancreatic cancer
sequential therapy
TGF-beta
Endogenous Pancreatic beta Cell Regeneration: A Potential Strategy for the Recovery of beta Cell Deficiency in Diabetes
期刊论文
FRONTIERS IN ENDOCRINOLOGY, 2019, 卷号: 10
作者:
Zhong, Fan
;
Jiang, Yan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
pancreatic beta cells
endogenous regeneration
pharmaceutical stimuli
rodent model
diabetes
A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma
期刊论文
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 卷号: 7, 期号: 1
作者:
Meng, Qingcai
;
Zhang, Yiyin
;
Xu, Jin
;
Hua, Jie
;
Liu, Jiang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Pancreatic ductal adenocarcinoma
PD-L2
Immune marker
Prognosis
TGF-beta 2
Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice.
期刊论文
Biochimica et biophysica acta. Molecular basis of disease, 2019, 卷号: 1865, 页码: 275-284
作者:
Li Jun
;
Xu Jie
;
Qin Xinghua
;
Yang Hongyan
;
Han Juntao
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/11/19
Acute hyperglycemia
IL-1&beta
Glycemic control
Insulin secretion
Pancreatic beta cell
Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis
期刊论文
CLINICAL CANCER RESEARCH, 2019, 卷号: 25, 页码: 1318-1330
作者:
Hu, Li-Peng
;
Zhang, Xiao-Xin
;
Jiang, Shu-Heng
;
Tao, Ling-Ye
;
Li, Qing
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/12/02
adenosine triphosphate
ar c118925xx
gemcitabine
glucose transporter 1
hypoxia inducible factor 1alpha
Myc protein
platelet derived growth factor beta receptor
platelet derived growth factor receptor
protein kinase Yes
purinergic P2Y receptor antagonist
purinergic P2Y2 receptor
unclassified drug
Yes1 protein, Akt signaling
animal experiment
animal model
animal tissue
Article
cancer inhibition
cancer prognosis
cancer staging
controlled study
drug potentiation
glycolysis
human
human cell
human tissue
inflammation
lymph node metastasis
male
mouse
mouse model
nonhuman
overall survival
pancreas adenocarcinoma
pancreatic ductal carcinoma cell line
Pi3K/Akt signaling
priority journal
RNA sequence
tumor classification
tumor differentiation
tumor microenvironment
tumor volume
tumor xenograft
Age-Characteristic Changes of Glucose Metabolism, Pancreatic Morphology and Function in Male Offspring Rats Induced by Prenatal Ethanol Exposure
期刊论文
FRONTIERS IN ENDOCRINOLOGY, 2019, 卷号: 10
作者:
Xiao, Di
;
Kou, Hao
;
Gui, Shuxia
;
Ji, Zhenyu
;
Guo, Yu
收藏
  |  
浏览/下载:74/0
  |  
提交时间:2019/12/05
prenatal ethanol exposure
intrauterine growth restriction
pancreatic beta cell development
insulin expression
glucocorticoids-insulin-like growth factor 1 axis
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