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北京大学 [9]
上海药物研究所 [9]
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长春应用化学研究所 [3]
厦门大学 [2]
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期刊论文 [32]
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c11anovelfibroblastgrowthfactorreceptor1fgfr1inhibitorsuppressesbreastcancermetastasisandangiogenesis
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 6, 页码: 823
作者:
Chen Zhuo
;
Tong Linjiang
;
Tang Baiyou
;
Liu Hongyan
;
Wang Xin
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
SELECTIVE INHIBITOR
THERAPEUTIC TARGET
DISCOVERY
ACTIVATION
EXPRESSION
PATHWAY
POTENT
C11
FGFR1 inhibitor
antitumor
breast cancer
metastasis
angiogenesis
Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents
期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2017, 卷号: 33, 期号: 3, 页码: 365-372
作者:
Zhang Lan
;
Deng Xinshan
;
Wu Jiaofeng
;
Meng Guangpeng
;
Liu Congchong
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/02/02
MOLECULAR TARGETED DRUGS
TYROSINE KINASE
CANCER-CELLS
EGFR
RESISTANCE
POTENT
DISCOVERY
NSCLC
Anticancer activity
Epidemal growth factor receptor(EGFR) inhibitor
N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative
Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents
期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2017, 卷号: 33, 期号: 3, 页码: 365-372
作者:
Zhang Lan
;
Deng Xinshan
;
Wu Jiaofeng
;
Meng Guangpeng
;
Liu Congchong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2021/02/02
MOLECULAR TARGETED DRUGS
TYROSINE KINASE
CANCER-CELLS
EGFR
RESISTANCE
POTENT
DISCOVERY
NSCLC
Anticancer activity
Epidemal growth factor receptor(EGFR) inhibitor
N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative
Loss of Dnmt3b accelerates MLL-AF9 leukemia progression
期刊论文
LEUKEMIA, 2016
Zheng, Y.
;
Zhang, H.
;
Wang, Y.
;
Li, X.
;
Lu, P.
;
Dong, F.
;
Pang, Y.
;
Ma, S.
;
Cheng, H.
;
Hao, S.
;
Tang, F.
;
Yuan, W.
;
Zhang, X.
;
Cheng, T.
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/12/03
ACUTE MYELOID-LEUKEMIA
HEMATOPOIETIC STEM-CELLS
GENE-EXPRESSION PROFILES
HEMATOLOGICAL MALIGNANCIES
DNA METHYLTRANSFERASE-1
POTENT INHIBITOR
CANCER
METHYLATION
TRANSFORMATION
MUTATIONS
基于天然产物aphadilactonec结构关键片段的二酰基甘油酰基转移酶1抑制剂的设计与合成
期刊论文
有机化学, 2016, 卷号: 36, 期号: 6, 页码: 1359
作者:
李丹
;
尹建朋
;
李静雅
;
南发俊
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  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
MICE
DISCOVERY
OBESITY
CLONING
POTENT
FAMILY
DGAT2
aphadilactone C
DGAT1
selective inhibitor
PF-04620110
AZD-7687
designsynthesisandbiologicalevaluationofbiphenylureaderivativesasvegfr2kinaseinhibitorsii
期刊论文
chinesechemicalletters, 2016, 卷号: 27, 期号: 2, 页码: 200
作者:
Gao Guorui
;
Li Mengyuan
;
Lv Yongcong
;
Cao Sufen
;
Tong Linjiang
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
GROWTH-FACTOR RECEPTOR-2
POTENT
ANGIOGENESIS
DISCOVERY
SORAFENIB
TOXICITY
CANCER
Angiogenesis
Kinase
Inhibitor
VEGFR-2
The development of a complementary pathway for the synthesis of aliskiren
期刊论文
organic & biomolecular chemistry, 2015, 卷号: 13, 期号: 4, 页码: 1133-1140
作者:
Li,Le-Le
;
Ding,Jin-Ying
;
Gao,Lian-Xun
;
Han,Fu-She
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2016/05/20
RENIN INHIBITOR ALISKIREN
ORALLY-ACTIVE INHIBITORS
OLEFIN CROSS-METATHESIS
CONVERGENT SYNTHESIS
RUTHENIUM CATALYSTS
OXIDATIVE CLEAVAGE
POTENT
CONVERSION
ALCOHOLS
KETONES
Design, Synthesis and Antitumor Activity of Novel 6,7-Dimethoxyquinazoline Derivatives Containing Diaryl Urea Moiety
期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2015, 卷号: 31, 期号: 5, 页码: 766-773
作者:
Hou Yunlei
;
Wu Shasha
;
Ma Longsheng
;
Bai Jinying
;
Liu Zijian
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  |  
浏览/下载:58/0
  |  
提交时间:2021/02/02
RECEPTOR TYROSINE KINASES
BIOLOGICAL EVALUATION
HIGHLY POTENT
INHIBITOR
IDENTIFICATION
GROWTH
DISCOVERY
SORAFENIB
EGFR
6,7-Dimethoxyquinazoline derivative
Diaryl urea scaffold
Cytotoxic activity
5氨基吡唑及5氨基三唑类成纤维细胞生长因子受体激酶抑制剂的设计合成
期刊论文
有机化学, 2015, 卷号: 35, 期号: 9, 页码: 1939
作者:
董潜
;
彭霞
;
王雯
;
戴阳
;
赵伟利
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2020/07/01
SELECTIVE INHIBITOR
ACTIVATING MUTATIONS
TYROSINE KINASE
CANCER
POTENT
CARCINOMA
FAMILY
FGFR2
5-aminopyrazole
5-amino-1,2,3-triazole
FGFR inhibitors
anti-tumor agent
The Enterovirus Protease Inhibitor Rupintrivir Exerts Cross-Genotypic Anti-Norovirus Activity and Clears Cells from the Norovirus Replicon
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 卷号: 58, 期号: 8, 页码: 4675-4681
Rocha-Pereira, J.
;
Nascimento, M. S. J.
;
Ma, Qingjun
;
Hilgenfeld, R.
;
Neyts, J.
;
Jochmans, D.
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  |  
浏览/下载:32/0
  |  
提交时间:2014/09/08
RHINOVIRUS 3C PROTEASE
IN-VITRO
NORWALK VIRUS
SUBSTRATE-SPECIFICITY
ANTIVIRAL ACTIVITY
POTENT INHIBITOR
GASTROENTERITIS
MODEL
REPLICATION
2'-C-METHYLCYTIDINE
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