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上海药物研究所 [4]
西安交通大学 [3]
安徽大学 [2]
复旦大学上海医学院 [2]
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兰州大学 [1]
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期刊论文 [19]
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Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Immunostimulatory Effects of Chitooligosaccharides on RAW 264.7 Mouse Macrophages via Regulation of the MAPK and PI3K/Akt Signaling Pathways
期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 1, 页码: 12
作者:
Yang, Yue
;
Xing, Ronge
;
Liu, Song
;
Qin, Yukun
;
Li, Kecheng
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2019/08/28
chitooligosaccharide
immunostimulatory activity
RAW 264
7 cells
mitogen-activated protein kinases (MAPK)
phosphoinositide 3-kinases (PI3K)
Akt
Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon gamma-activated murine macrophages and animal models of inflammation
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2018, 卷号: 105, 期号: 2018, 页码: 606-615
作者:
Zhao, Lin
;
Wang, Lun
;
Di, Suo-ni
;
Xu, Qian
;
Ren, Qing-cuo
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/12/24
Solanine A
Solanum nigrum Linn.
Anti-inflammatory activity
NF-kappa B and MAPKs cascades
PI3K/Akt and JAK/STATs signalings
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
作者:
Liang, Xiaofei
;
Li, Feng
;
Chen, Cheng
;
Jiang, Zongru
;
Wang, Aoli
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/10
PI3K delta
Kinase inhibitor
Acute myeloid leukemia
Structure-activity relationship
Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 8, 页码: 782-792
作者:
Yu, Dandan
;
Zhang, Yong
;
Chen, Gege
;
Xie, Yongsheng
;
Xu, Zhijian
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/01/08
mantle cell lymphoma
pterostilbene
antiproliferative activity
PI3K/Akt/mTOR pathway
synergistic cytotoxicity
Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3K delta) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 页码: 2028-2040
作者:
Xin, Minhang
;
Duan, Weiming
;
Feng, Yifan
;
Hei, Yuan-Yuan
;
Zhang, Hao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/11/26
4-Pyrrolidineaminoquinazoline
Structure-activity relationship
Anti-proliferation
PI3K delta inhibitors
6-Aryl
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor
期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: Vol.156, 页码: 831-846
作者:
Zongru Jiang
;
Wenliang Wang
;
Fengming Zou
;
Jing Liu
;
Qingsong Liu
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/04/22
PI3Kδ
Kinase
inhibitor
Acute
myeloid
leukemia
Structure-activity
relationship
Discovery of -2-amino-N-pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide as a potent and selective phosphoinositide 3-kinase delta inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: Vol.156, 页码: 831-846
作者:
Liu, Xiaochuan
;
Jiang, Zongru
;
Li, Feng
;
Hu, Zhenquan
;
Ge, Juan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/04/24
PI3K
delta
Kinase
inhibitor
Acute
myeloid
leukemia
Structure-activity
relationship
Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon gamma-activated murine macrophages and animal models of inflammation
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2018, 卷号: Vol.105, 页码: 606-615
作者:
Zhao, Lin
;
Wang, Lun
;
Di, Suo-ni
;
Xu, Qian
;
Ren, Qing-cuo
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/02/25
Solanine A
Solanum nigrum Linn.
Anti-inflammatory activity
NF-kappa B and MAPKs cascades
PI3K/Akt and JAK/STATs signalings
targetingthepi3kaktmtorsignalingpathwaybypterostilbeneattenuatesmantlecelllymphomaprogression
期刊论文
actabiochimicaetbiophysicasinica, 2018, 卷号: 50, 期号: 8, 页码: 782
作者:
Yu Dandan
;
Zhang Yong
;
Chen Gege
;
Xie Yongsheng
;
Xu Zhijian
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
PROTEIN-KINASE PATHWAY
CANCER IN-VITRO
TRANSDUCTION PATHWAYS
CYCLE ARREST
APOPTOSIS
ACTIVATION
PATHOGENESIS
INHIBITION
ANTICANCER
EXPRESSION
mantle cell lymphoma
pterostilbene
antiproliferative activity
PI3K/Akt/mTOR pathway
synergistic cytotoxicity
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