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科研机构
山东大学 [5]
上海药物研究所 [3]
大连理工大学 [1]
新疆理化技术研究所 [1]
大连化学物理研究所 [1]
复旦大学上海医学院 [1]
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期刊论文 [12]
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2018 [4]
2015 [1]
2013 [3]
2012 [4]
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Chemistry [1]
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Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
;
Li, Xiaokang
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease
Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 页码: 30-38
作者:
Zheng, Hongbo
;
Li, Lin
;
Sun, Bin
;
Gao, Yun
;
Song, Wei
收藏
  |  
浏览/下载:114/0
  |  
提交时间:2019/12/11
PDE5 inhibitors
Pyrroloquinolones
Bioavailability
Male erectile
dysfunction (MED)
Discovery of furyl/thienyl beta-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 767-780
作者:
Zheng, Hongbo
;
Wu, Yifeng
;
Sun, Bin
;
Cheng, Chuanle
;
Qiao, Yanan
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
beta-Carboline derivatives
PDE5 inhibitors
Vasorelaxant effect
Structure-activity relationship
Discovery of furyl/thienyl β-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect
期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 158, 页码: 767-780
作者:
Zheng H.
;
Wu Y.
;
Sun B.
;
Cheng C.
;
Qiao Y.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
PDE5 inhibitors
Structure-activity relationship
Vasorelaxant effect
β-Carboline derivatives
preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528
作者:
Gao Zhiwei
;
Zhu Yunting
;
Yu Mingming
;
Zan Bin
;
Liu Jia
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
HUMAN DRUG CLEARANCE
PHOSPHODIESTERASE-5 INHIBITORS
CLINICAL PHARMACOKINETICS
ERECTILE DYSFUNCTION
TISSUE DISTRIBUTION
ORAL PHARMACOKINETICS
RECEPTOR ANTAGONIST
DIVERSE COMPOUNDS
IN-VIVO
ABSORPTION
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
作者:
Gong, Xudong
;
Wang, Guan
;
Ren, Jing
;
Liu, Zheng
;
Wang, Zhen
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
PDE5 inhibitors
5-Bromopyrimidin-4(3H)-ones
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
作者:
Gong Xudong
;
Wang Guan
;
Ren Jing
;
Liu Zheng
;
Wang Zhen
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2013/11/07
PDE5 inhibitors
5-Bromopyrimidin-4(3H)-ones
Penile rehabilitation after radical prostatectomy: patients' attitude and feasibility in China.
期刊论文
Translational andrology and urology, 2013, 卷号: 2, 期号: 1
作者:
Shen Yi-Jun
;
Li Jian
;
Ye Ding-Wei
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/19
Attitude
PDE5 inhibitors
erectile dysfunction
penile rehabilitation
radical prostatectomy
vacuum erection device
Exploring the structure determinants of pyrazinone derivatives as PDE5 3HC8 inhibitors: An in silico analysis
期刊论文
journal of molecular graphics & modelling, 2012, 卷号: 38, 页码: 112-122
作者:
Li, Yan
;
Wu, Wenzhao
;
Ren, Hong
;
Wang, Jinghui
;
Zhang, Shuwei
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2015/11/13
PDE5
Pyrazinone-based inhibitors
3D-QSAR
Molecular docking
Molecular dynamics
Exploring the structure determinants of pyrazinone derivatives as PDE5 3HC8 inhibitors: An in silico analysis
期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2012, 卷号: 38, 页码: 112-122
作者:
Li, Yan
;
Wu, Wenzhao
;
Ren, Hong
;
Wang, Jinghui
;
Zhang, Shuwei
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/13
PDE5
Pyrazinone-based inhibitors
3D-QSAR
Molecular docking
Molecular dynamics
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