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科研机构
上海药物研究所 [8]
山东大学 [7]
复旦大学上海医学院 [6]
中国医学科学院 北京... [5]
西安交通大学 [2]
兰州大学 [2]
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期刊论文 [33]
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NME4 may enhance non-small cell lung cancer progression by overcoming cell cycle arrest and promoting cellular proliferation
期刊论文
MOLECULAR MEDICINE REPORTS, 2019, 卷号: 20, 期号: 2
作者:
Wang, Wenqian
;
Dong, Ming
;
Cui, Jie
;
Xu, Fei
;
Yan, Chen
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
nucleoside diphosphate kinase 4
non-small cell lung cancer
cell proliferation
apoptosis
cell cycle
Discovery of a semi-synthesized cyclolignan as a potent HIV-1 non-nucleoside reverse transcriptase inhibitor
期刊论文
2019, 卷号: 21, 期号: 1, 页码: 76-85
作者:
Guo, Jia-Mei
;
Ba, Ming-Yu
;
Yang, Ying
;
Yao, Chun-Suo
;
Yu, Miao
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/03
Cyclolignan
HIV-1
non-nucleoside reverse transcriptase inhibitor
drug resistance
drug combinations
Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 12, 页码: 2900-2906
作者:
Cheng, Yu
;
Shen, Jian
;
Peng, Run-Ze
;
Wang, Gui-Feng
;
Zuo, Jian-Ping
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
HCV NS5B polymerase
2-Alkyl quinolone
1,6-Naphthyridine-4,5-dione
Non-nucleoside inhibitor
Direct acting antiviral
Allosteric site
Design, synthesis and evaluation of pyrazole derivatives as non-nucleoside hepatitis B virus inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 123, 页码: 202-210
作者:
Jia, Haiyong
;
Bai, Fuxiang
;
Liu, Na
;
Liang, Xiaohong
;
Zhan, Peng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/16
HBV
Bioisosterism
Hybrid pharmacophore-based
Non-nucleoside
SAR
Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 87, 期号: 2, 页码: 283-289
作者:
Huang, Boshi
;
Li, Xiao
;
Zhan, Peng
;
De Clercq, Erik
;
Daelemans, Dirk
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/17
anti-HIV activity
bioisosterism
HIV-1 RT
molecular hybridization
non-nucleoside reverse transcriptase inhibitors
Substituted indoles as HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent evaluation (WO2015044928)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2016, 卷号: 26, 期号: 5, 页码: 629-635
作者:
Li, Xiao
;
Gao, Ping
;
Zhan, Peng
;
Liu, Xinyong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/17
HIV
non-nucleoside reverse transcriptase inhibitors
substituted
indole
heterocycle
antiviral activity
2,4,5-Trisubstituted thiazole derivatives as HIV-1 NNRTIs effective on both wild-type and mutant HIV-1 reverse transcriptase: Optimization of the substitution of positions 4 and 5
期刊论文
2016, 卷号: 123, 页码: 309-316
作者:
Xu, Zhongliang
;
Guo, Jiamei
;
Yang, Ying
;
Zhang, Mengdi
;
Ba, Mingyu
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
HIV-1
Non-nucleoside reverse transcriptase inhibitors
2
4
5-Trisubstituted thiazole derivatives
Structure optimization
Structure activity relationship
Non-Covalent Albumin Conjugates of Silicon(IV) Phthalocyanines Axially Substituted with Nucleoside: Preparation and in vitro Photodynamic Activities
期刊论文
SPECTROSCOPY AND SPECTRAL ANALYSIS, 2015, 卷号: 35, 页码: 457-461
作者:
Yang Xiao-mei
;
Zheng Bi-yuan
;
Cai Yue
;
Lin Ai-lan
;
Shen Xiao-min
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/11/21
Non-covalent conjugate
Albumin
Silicon phthalocyanine
Nucleoside
Photodynamic activity
Novel fluorine-containing DAPY derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2014072419
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2015, 卷号: 25, 期号: 12, 页码: 1477-1486
作者:
Meng, Qing
;
Liu, Na
;
Huang, Boshi
;
Zhan, Peng
;
Liu, Xinyong
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/17
diarylpyrimidines
drug design
fluorine atom
HIV inhibitors
non-nucleoside reverse transcriptase inhibitors
A Nanoparticle-Encapsulated Non-Nucleoside Reverse-Transcriptase Inhibitor with Enhanced Anti-HIV-1 Activity and Prolonged Circulation Time in Plasma
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2015, 卷号: 21, 期号: 7
作者:
Li, Wen
;
Wang, Qian
;
Li, Yuan
;
Yu, Fei
;
Liu, Qi
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/13
HIV-1
antiretroviral therapy
non-nucleoside reverse-transcriptase inhibitor
nanoparticles
drug resistance
pharmacokinetics
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